ESC & iPSC News Volume 19.01 | Jan 17 2024

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    2024-01-17 | ESC 19.02


    ESC & iPSC News by STEMCELL Technologies
    Vol. 19.01 – 17 January, 2024
    TOP STORY

    Dissolution of Ribonucleoprotein Condensates by the Embryonic Stem Cell Protein L1TD1

    Scientists determined RNAs associated with L1TD1 and found that, like ORF1p, L1TD1 bound L1 RNAs and localized to high-density ribonucleoprotein condensates.
    [Nucleic Acids Research]

    Full ArticleGraphical Abstract
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    Incomplete Reprogramming of DNA Replication Timing in Induced Pluripotent Stem Cells

    Researchers compared genome-wide replication timing between ESCs, iPSCs, and cells reprogrammed by somatic cell nuclear transfer.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Engineering Human Pluripotent Stem Cell Lines to Evade Xenogeneic Transplantation Barriers

    T cell, Natural Killer cell, and complement evasion are necessary to prevent immunological rejection of hPSCs and their progeny.
    [Stem Cell Reports]

    Full Article

    Human Pluripotent Stem Cell Modeling of Alveolar Type 2 Cell Dysfunction Caused by ABCA3 Mutations

    Researchers reported the generation of alveolar type II epithelial cells from affected patient iPSCs carrying homozygous versions of multiple ATP-binding cassette A3 (ABCA3) mutations.
    [European Journal Of Clinical Investigation]

    Full Article

    ROR2 Expression Predicts Human Induced Pluripotent Stem Cell Differentiation into Neural Stem/Progenitor Cells and GABAergic Neurons

    Investigators attempted to identify marker genes that could predict the differentiation propensity of hiPSCs into neural stem/progenitor cells.
    [Scientific Reports]

    Full Article

    Comparison of the Calcium Signaling Alterations in GABA-Ergic Medium Spiny Neurons Produced from iPSCs of Different Origins

    Scientists studied the features of calcium homeostasis in GABA-ergic medium spiny neurons differentiated from iPSCs obtained from fibroblasts of the same donor using different methods.
    [Biochimie]

    Abstract

    Genetic Correction of Induced Pluripotent Stem Cells from a DFNA36 Patient Results in Morphologic and Functional Recovery of Derived Hair Cell-Like Cells

    The authors investigated the differentiation, morphology and electrophysiological properties of hair cell-like cells derived from DFNA36 patient.
    [Current Stem Cell Research & Therapy]

    Full Article

    COL1A1 Regulates the Apoptosis of Embryonic Stem Cells by Mediating the PITX1/TBX4 Signaling

    Scientists explored the regulatory function of COL1A1 against the apoptosis of ESCs and the potential function in congenital talipes equinovarus.
    [Birth Defects Research]

    Full Article

    Generation of Three Isogenic Human Induced Pluripotent Stem Cell Lines from Normal Neonate Skin Fibroblasts

    Investigators report the establishment of three isogenic hiPSC lines generated from normal neonate male skin fibroblasts. Pluripotency was induced using the integration free Sendai virus reprogramming method.
    [Stem Cell Research]

    Full Article
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    REVIEWS

    Unleashing the Power of Undifferentiated Induced Pluripotent Stem Cell Bioprinting: Current Progress and Future Prospects

    The authors cover the fundamental concepts and techniques of bioprinting and bioink design, reviewing recent progress in iPSC bioprinting research with a specific focus on bioprinting undifferentiated iPSCs, and conclude by discussing existing limitations and future prospects.
    [International Journal Of Stem Cells]

    Abstract
    INDUSTRY AND POLICY NEWS

    Cloned Rhesus Monkey Lives to Adulthood for First Time

    For the first time, a rhesus monkey cloned in the laboratory has lived into adulthood — surviving for more than two years so far.
    [Nature News]

    Press Release

    Postdoctoral Researchers Awarded Hartwell Fellowships to Probe Tissue Regeneration and Molecular Roots of Dystonia

    Ben Cox and Rebecca McGillivary, postdoctoral researchers in the Department of Molecular and Cellular Biology, are among 10 early career scientists selected to receive 2022 Hartwell Biomedical Research Fellowships, which were announced in August, 2023.
    [UC Davis]

    Press Release
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    JOB OPPORTUNITIES

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    Guangzhou Institutes of Biomedicine and Health – Guangzhou, China

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    Cedars-Sinai Board – Anaheim, California, United States

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