 | | Vol. 19.02 – 24 January, 2024 |
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| Researchers investigated the transcription factors regulomes during the first lineage specification in early mouse embryos, spanning the pre-initiation, initiation, commitment, and maintenance phases.
[Nature Structural & Molecular Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that Xenopus laevis embryos were much more sensitive to a diverse set of chemical and molecular-biological perturbations when allowed to develop alone or in small groups, than in large groups.
[Nature Communications] |
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| Using Zfp281 knockout mouse and degron knockin cell models, investigators identified the direct transcriptional activation of Dnmt3a/3b by ZFP281 in PSCs.
[Developmental Cell] |
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| Natural killer (NK) cell deficiency in a patient presented as loss of functionally mature late-stage NK cells. To understand how MCM10 deficiency affects NK cell development, researchers generated MCM10 heterozygous iPSC lines.
[Open Biology] |
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| To further understand the role of the ubiquitin proteasome system in pluripotency, investigators performed an RNAi screen during induction of cellular reprogramming and have identified FBXO9 as a novel regulator of pluripotency associated protein DPPA5.
[Stem Cells] |
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| Researchers showed that human-iPSCs reprogrammed from somatic cells show progressive telomere lengthening until reaching a length similar to ESCs.
[Cell Cycle] |
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| Investigators took advantage of disease-specific iPS cells and generated & characterized the heterozygous ATTR Tyr114Cys amyloidosis-specific iPS cells, to determine whether Y114C iPS cells could be useful for elucidating the pathogenesis of ATTR Tyr114Cys amyloidosis.
[Heliyon] |
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| Urine-derived epithelial cells were collected from the fresh urine of a healthy donor and transducted with reprogramming plasmid mixture to generate iPSCs.
[International Journal Of Medical Sciences] |
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| Researchers reprogrammed skin fibroblasts of one male individual and generated two iPSC lines, which exhibited the characteristic ESC-like morphology, demonstrated robust expression of key pluripotency factors, and displayed multilineage differentiation potential.
[Stem Cell Research] |
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| Investigators explored the impact of different 3D bioprinting technologies and bioink materials on seed cells, providing a comprehensive overview of the current landscape of cell sources that have been used or hold potential in 3D bioprinting.
[Heliyon] |
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| The authors focus on the progress made with iPSC lines derived from endangered and extinct species, exploring their potential applications and limitations in animal welfare research.
[Veterinary Research Communications] |
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| The critically endangered northern white rhino could be saved from the brink of extinction after scientists performed the first successful embryo transfer in white rhinos.
[The Guardian] |
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| The US Environmental Protection Agency (EPA) has abandoned a controversial plan to phase out all use of mammals to test the safety of chemicals by 2035. The hard deadline made EPA unique among US federal agencies.
[Science Insider] |
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| March 11 – 14, 2024
San Diego, California, United States |
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| | STEMCELL Technologies – Vancouver, British Columbia, Canada |
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| | National University of Singapore – Singapore, Singapore |
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| | University of Alberta – Edmonton, Alberta, Canada |
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| | Human Technopole – Milan, Italy |
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| | Guangzhou Institutes of Biomedicine and Health – Guangzhou, China |
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