 | | Vol. 19.03 – 31 January, 2024 |
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| The authors explored the effects of mitochondrial dysfunction on the neuronal reprogramming of iPSC-derived astrocytes carrying mutations in the NDUFS4 gene, important for Complex I and associated with Leigh syndrome.
[Neuron] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators used murine iPSCs generated from mouse embryonic fibroblasts with triple factor transduction to determine the efficacy and action mechanism of iPSC-derived exosomes in attenuating pulmonary arterial hypertension.
[Cardiovascular Research] |
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| In Muse cells, researchers demonstrated that let-7 inhibited the PI3K-AKT pathway, leading to sustainable expression of the key pluripotency regulator KLF4 as well as its downstream genes, POU5F1, SOX2, and NANOG.
[Cellular And Molecular Life Sciences] |
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| Microglia were successfully differentiated from retinoblastoma patient-derived human iPSCs and hESCs, and researchers investigated the function of RB1 in microglia by live imaging phagocytosis assay, immunofluorescence, RNA-seq, qRT-PCR, ELISA, and retina organoids/microglia co-culturing.
[Glia] |
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| Following culture under simulated microgravity in a random positioning machine for seven days, 3D hiPSC-cardiomyocytes had increased mitochondrial content as detected by a mitochondrial protein and mitochondrial DNA to nuclear DNA ratio.
[Scientific Reports] |
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| Scientists described the first successful integration-free reprogramming of adult somatic cells to iPSCs, and their differentiation, from three endangered Southeast Asian primates: the Celebes Crested Macaque, the Lar Gibbon, and the Siamang.
[Scientific Reports] |
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| Scientists employed a comprehensive methodology involving the differentiation of iPSCs into mesenchymal stem cells (MSCs). The process was meticulously designed to ensure the expression of key MSC positive markers at elevated levels, coupled with the minimal expression of negative markers.
[Journal Of The Chinese Medical Association] |
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| Using microarray and Gene Set Enrichment Analysis, scientists found that hiPSC-small intestinal epithelial cell monolayers activated the immune response and enhanced the mucosal barrier in response to IL-22.
[FEMS Microbiology Letters] |
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| The Vervet monkey serves as an important primate model for such studies, and therefore researchers reprogrammed skin fibroblasts derived from a male and a female individual, resulting in two iPSCs.
[Stem Cell Research] |
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| Investigators introduce new model system of Parkinson’s disease, including 2D human iPSC-derived midbrain dopaminergic neurons, 3D iPSC-derived midbrain organoids with cellular complexity, and more advanced microphysiological systems with 3D organoids.
[Advanced Healthcare Materials] |
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| Political advisors for the Shanghai government have urged relevant parties to work toward making the city a global hub for stem cell research, development and industrialization.
[Capital News] |
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| A Murdoch Children’s Research Institute researcher has received an Australia Day honor. Associate Professor Ngaire Elwood has been awarded the Member of the Order of Australia in the General Division for significant service to medicine, particularly through stem cell research.
[Mirage News] |
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| March 11 – 13, 2024
Lisbon, Portugal |
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| | Cellistic – Mont-Saint-Guibert, Belgium |
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| | The Jackson Lab – Farmington, Connecticut, United States |
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| | reNEW – Copenhagen, Denmark |
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| | National University of Singapore – Singapore, Singapore |
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| | University of Alberta – Edmonton, Alberta, Canada |
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