 | | Vol. 19.05 – 7 February, 2024 |
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| Scientists developed a human pluripotent stem cell-based approach to synchronize the birth of cortical neurons in vitro which helped to define an atlas of morphological, functional, and molecular maturation.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers stimulated the retinoic acid (RA) pathway by treating zebrafish embryos with all-trans-RA and used a combination of RNA-seq, ATAC-seq, ChIP-seq and HiChIP to gain insight into the molecular mechanisms by which exogenously induced RA signaling controlled gene expression.
[Nucleic Acids Research] |
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| Investigators demonstrated that teratomas derived from aneuploid murine ESCs, but not from isogenic diploid ESCs, disseminated to multiple organs, for which no additional copy number variations were required.
[Nature Communications] |
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| Using mass spectrometry-based interactomics methods, affinity purification-mass spectrometry and proximity-dependent biotin labeling, and chromatin immunoprecipitation sequencing, scientists derived the comprehensive regulatory networks of these preimplantation transcription factors.
[EMBO Reports] |
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| To study the intermediate stages of early and late gastrulation, researchers determined the transcriptomes of the 1- to 102-cell stage to identify 119 embryonic cell-states during cell-fate specification, including ‘equivalence-group’ cell identities.
[eLife] |
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| The authors generated iPSCs from healthy fetal liver (FL) cells and produced isogenic primitive or definitive red blood cells (RBCs) which were compared directly to the FL-derived RBCs.
[Blood Advances] |
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| Scientists showed that the degree of coordination of allelic bursting differed among genes, and alleles of many reprogramming-related genes burst in a highly coordinated fashion.
[Life Science Alliance] |
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| Administration of Go6983 increased Prdm14 expression mainly through the inhibition of PKCδ. High constitutive expression of Prdm14 phenocopied the ability of Go6983 to maintain` mouse ESC stemness in the absence of self-renewal-promoting cytokines.
[Journal Of Biological Chemistry] |
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| Researchers examined the electrophysiological mechanism of early repolarization syndrome (ERS) utilizing iPSCs and CRISPR/Cas9 genome editing. Whole genome sequencing was used to identify the dipeptidyl-peptidase 6 (DPP6) variant in four families with sudden cardiac arrest induced by ERS.
[Experimental Cell Research] |
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| With NKX2.5eGFP H9 hESCs, investigators established single and double knockout cell lines for HAND1 and HAND2, respectively, whose cardiomyocyte differentiation efficiency could be monitored by assessing NKX2.5-eGFP+ cells with flow cytometry.
[Current Stem Cell Research & Therapy] |
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| The authors highlight studies from the past five years on the contributions of iPSCs within neuroproteomic investigations, which uncover the molecular mechanisms behind neurodegenerative illnesses.
[Academic Radiology] |
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| Third-year students at the Harvard John A. Paulson School of Engineering and Applied Sciences worked with the Harvard Stem Cell Institute iPS Core Facility last fall to design a pair of solutions to reduce the time spent on day-to-day operations.
[Harvard University] |
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| NASA astronaut Kate Rubins conducted hundreds of experiments during her time on the International Space Station; now she discusses her experience conducting this pioneering research on the orbiting laboratory.
[ISS National Laboratory] |
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| March 13 – 15, 2024
Vienna, Austria |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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| | Rutgers, New Jersey Medical School – Newark, New Jersey, United States |
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| | The University of Manchester – Manchester, England, United Kingdom |
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