 | | Vol. 19.05 – 14 February, 2024 |
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| To establish a global framework for exploring mammalian development, researchers applied optimized single-cell combinatorial indexing3 to profile the transcriptional states of 12.4 million nuclei from 83 embryos, precisely staged at two- to six-hour intervals spanning late gastrulation to birth.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| SScientists introduced an approach for inferring sex-specific recombination landscapes using data from preimplantation genetic testing for aneuploidy.
[Genome Research] |
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| Preferentially Expressed Antigen in Melanoma-like 7 (RAMEL7) recruited Cullin2 (CUL2) to chromatin and targeted regulators of repressive chromatin, including the Nucleosome Remodeling and Deacetylase (NuRD) complex, for proteasomal degradation.
[EMBO Reports] |
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| Investigators explored whether macrophages derived from human iPSCs—which proliferate indefinitely and potentially provide unlimited starting material—could serve as a faithful model system for studying virus biology.
[Journal Of Virology] |
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| Scientists compared the susceptibility of neonatal human dermal fibroblast cells and human hiPSCs derived from neonatal human dermal fibroblast cells, which were genetically identical to human cytomegalovirus, using immunostaining, microarray, in situ hybridization, quantitative PCR, and SEM.
[Journal Of Virology] |
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| The authors used multi-omics analyses to identify and characterize stemness genes, and focused on the zinc finger protein 982 that regulated stemness through the expression of Nanog, Zfp42, and Dppa3 in mouse ESCs.
[Biochimica Et Biophysica Acta-Molecular Cell Research] |
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| Researchers established M. minutoides iPSCs using the PiggyBac transposon system for applications in developmental engineering. The established M. minutoides iPSCs were found to express pluripotency markers and could differentiate into neurons.
[Scientific Reports] |
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| The authors demonstrated that the primed pluripotent state could generate trophoblast stem cells by activating pathways such as Epidermal Growth Factor and Wingless-related integration site.
[Scientific Reports] |
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| Scientists generated a hiPSC line from erythroid progenitor cells of a 20-year-old female healthy donor using Sendai virus vector encoding Yamanaka factors OCT3/4, SOX2, c-MYC, and KLF4.
[Stem Cell Research] |
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| Investigators describe how autophagy influences postembryonic development in the context of neuronal and cardiac development, wound healing, and tissue regeneration.
[Journal Of Molecular Biology] |
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| Transplantation of hPSC-cardiomyocytes (CMs) into the myocardium of large animals in a myocardial infarction model improved cardiac function. The engrafted hPSC-CMs matured, and microvessels derived from the host entered the graft abundantly.
[Journal Of Molecular And Cellular Cardiology] |
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| While training for the upcoming mission was underway, two NASA Flight Engineers, Jasmin Moghbeli and Loral O’Hara, focused a majority of their day on the Mesenchymal Stem Cells in Microgravity Induced Bone Loss investigation.
[NASA Space Station] |
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| March 18 – 19, 2024
London, England, United Kingdom |
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| | UC Davis – Davis, California, United States |
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| | Cyprus Cancer Research Institute – Aglandjia, Cyprus |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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