ESC & iPSC News Volume 19.06 | Feb 21 2024

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    2024-02-21 | ESC 19.06


    ESC & iPSC News by STEMCELL Technologies
    Vol. 19.06 – 21 February, 2024
    TOP STORY

    Generation of Complex Bone Marrow Organoids from Human Induced Pluripotent Stem Cells

    Investigators presented a method for generating complex bone marrow-like organoids from human-induced pluripotent stem cells.
    [Nature Methods]

    Full Article
    Learn how to be a great STEM mentor to new lab members
    PUBLICATIONSRanked by the impact factor of the journal

    Large-Scale Smart Bioreactor with Fully Integrated Wireless Multivariate Sensors and Electronics for Long-Term In Situ Monitoring of Stem Cell Culture

    Scientists introduced a smart bioreactor system that enabled multi-spatial sensing for real-time, wireless culture monitoring. This scalable system included a low-profile, label-free thin-film sensor array and electronics integrated with a flexible cell bag.
    [Science Advances]

    Full Article

    Determining the Potency of Primordial Germ Cells by Injection Into Early Mouse Embryos

    The authors demonstrated that primordial germ cells injected into eight-cell embryos could initially survive, divide, and contribute to the developing inner cell mass.
    [Developmental Cell]

    Full ArticleGraphical Abstract

    Differentiation of Human Induced Pluripotent Stem Cell-Derived Dental Stem Cells through Epithelial-Mesenchymal Interaction

    Investigators established hiPSCs-derived mesenchymal stem cells and differentiated them into dental cells with hiPSCs-derived dental epithelial-like cells.
    [Stem Cells And Development]

    Abstract

    Identification of a Family with Van Der Hoeve’s Syndrome Harboring a Novel COL1A1 Mutation and Generation of Patient-Derived iPSC Lines and CRISPR/Cas9-Corrected Isogenic iPSCs

    Scientists established two iPSC lines from peripheral blood mononuclear cells of osteogenesis imperfecta patients carrying a novel mutation in the COL1A1 gene.
    [Human Cell]

    Abstract

    Establishment and Characterization of ZJUCHi003: An Induced Pluripotent Stem Cell Line from a Patient with Temple-Baraitser/Zimmermann-Laband Syndrome Carrying KCNH1 c.1070G > a (p.R357Q) Variant

    Researchers established an iPSC line using urinary cells from a girl with KCNH1 recurrent/hotspot pathogenic variant c.1070G > A (p.R357Q).
    [Human Cell]

    Abstract

    Transplantation of Human Embryonic Stem Cell-Derived Pericyte-Like Cells Transduced with Basic Fibroblast Growth Factor Promotes Angiogenic Recovery in Mice with Severe Chronic Hindlimb Ischemia

    Investigators generated highly proliferative and immunosuppressive pericyte-like cells from ESCs. In order to enhance the angiogenic potential, they transduced the basic fibroblast growth factor gene into the pericyte-like cells and found a significant enhancement of angiogenesis in a Matrigel plug assay.
    [Journal Of Cardiovascular Translational Research]

    AbstractGraphical Abstract

    Establishment of FDHSi003-A, a Human Induced Pluripotent Stem Cell (hiPSC) Line with a Mutation of RNF216 c.1948G > T

    The authors established a hiPSC line, FDHSi003-A, derived from PBMC of a patient bearing a mutation of RNF216 c.1948G > T, who shows typical symptoms of Gordon Holmes Syndrome.
    [Stem Cell Research]

    Abstract

    Generation of Induced Pluripotent Stem Cell Line, NIMHi009-A, from PBMCs of an Adult Healthy Male

    Scientists generated and characterized human iPSC line NIMHi009-A derived from PBMCs of healthy adult male control for an epileptic patient carrying voltage-gated sodium channel mutation, using Sendai virus-based reprogramming.
    [Stem Cell Research]

    Abstract
    Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTect™ CRISPR-Cas9 System.
    REVIEWS

    Epigenetic Reprogramming in the Transition from Pluripotency to Totipotency

    The authors highlight the recent findings in understanding the mechanisms of epigenetic remodeling during totipotency capture, including RNA splicing, DNA methylation, chromatin configuration, histone modifications, and nuclear organization.
    [Journal of Cell Physiology]

    Abstract
    INDUSTRY AND POLICY NEWS

    22nd Wiley Prize Honors Stem Cell Niche Research

    The Wiley Foundation announced that the 22nd annual Wiley Prize in Biomedical Sciences will be awarded to Judith Kimble, Allan Spradling, and Raymond Schofield for their discovery of the stem cell niche, a localized environment that controls stem cell identity.
    [Mirage News]

    Press Release
    FEATURED EVENT

    46th JSTCT Annual Meeting (JSTCT2024) Japanese Society for Transplantation and Cellular Therapy

    March 21 – 23, 2024
    Tokyo, Japan

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Molecular Neurobiology and iPSC

    University of Antwerp – Antwerp, Belguim

    Postdoctoral Researcher – Placenta-Brain Axis

    University of Amsterdam – Amsterdam, Netherlands

    Postdoctoral Researcher – Stem Cell Therapy for Stroke

    University of Barcelona – Barcelona, Catalonia, Spain

    Department Chair – Cell Biology and Human Anatomy

    UC Davis – Davis, California, United States

    Postdoctoral Scientists – Molecular Basis of Cancer

    Cyprus Cancer Research Institute – Aglandjia, Cyprus

    > See All Jobs

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