 | | Vol. 19.07 – 28 February, 2024 |
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| Investigators showed that quiescent embryonic stem cells possess an expanded or unrestricted cell fate, capable of generating both embryonic and extraembryonic cell types.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that autophagy-related protein ATG5 was essential for both attenuated inflammatory response and differentiation of mouse ESCs and that attenuation of inflammatory signaling was required for mouse ESC differentiation.
[Developmental Cell] |
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| Scientists reported that Sass6‑mutant mouse embryos lack centrioles, activate the mitotic surveillance cell death pathway, and were arrested at mid‑gestation. In contrast, SAS‑6 was not required for centriole formation in mouse ESCs, but was essential to maintain centriole architecture.
[eLife] |
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| Scientists described the establishment of the first clinical-grade iPSC lines from umbilical cord mesenchymal stromal cells in Brazil.
[Stem Cells Translational Medicine] |
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| Investigators defined the transcriptional consequences of TBXT dosage reduction during early human gastrulation using hiPSC models of gastrulation and mesoderm differentiation.
[Development] |
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| Researchers conducted integrated proteomics, lipidomics, and metabolomics analyses with confident identification, accurate quantification, and reproducible measurements to compare the molecular profiles of human iPSCs and iPSC-derived neurons.
[Journal Of Proteome Research] |
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| Investigators demonstrated that steady-state dynamics involving two bistable switches which were interlinked via a stepwise and a mushroom-like manner orchestrate the fate specification of embryonic stem cells.
[FEBS Letters] |
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| A human iPSCs line was established from a 4-year-1-month-old girl with subcortical band heterotopia carrying a heterozygous mutation in DCX. The generated iPSC line showed the ability to differentiate into three lineages in vitro and was confirmed by pluripotency markers and the original gene mutation.
[Stem Cell Research] |
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| Scientists established hiPSC line, NIMHi010-A of a 42-year-old healthy donor. The iPSC line was generated from human dermal fibroblasts using Sendai viruses carrying reprogramming factors c-MYC, SOX2, KLF4, and OCT4 under a feeder-free culture system.
[Stem Cell Research] |
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| The authors delve into the hallmarks of totipotent and pluripotent stem cells, shedding light on their key molecular and functional features.
[Cell Stem Cell] |
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| Scientists explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions.
[Nature Communications] |
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| The University of California, Irvine (UCI) received a five-year, $4 million grant from the California Institute for Regenerative Medicine to establish a shared resources lab in the Sue & Bill Gross Stem Cell Research Center.
[UCI News] |
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| April 4 – 5, 2024
Cincinnati, Ohio, United States |
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| | University of Bristol – Bristol, England, United Kingdom |
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| | King’s College London – London, England, United Kingdom |
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| | University of Antwerp – Antwerp, Belguim |
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| | University of Amsterdam – Amsterdam, Netherlands |
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| | University of Barcelona – Barcelona, Catalonia, Spain |
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