 | | Vol. 19.08 – 6 March, 2024 |
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| The functional consequences of ZSCAN10 loss were modeled in mouse ESC, including a knock-out and a representative ZSCAN10 protein-truncating variant.
[Brain] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers developed a human PSC model to investigate the divergence between amniotic and surface ectoderms. In the established culture system, cells differentiated into functional amnioblast-like cells.
[Science Advances] |
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| Scientists investigated the etiology of the novel mutation in the GLA gene in affected patients by using induced pluripotent stem cells iPSCs as a valuable tool.
[Qjm-An International Journal Of Medicine] |
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| Researchers established a robust Down syndrome (DS) model harnessing hiPSCs from mosaic DS patients. These hiPSC lines encompassed both those with standard karyotype and those carrying an extra copy of extra copy of chromosome 21.
[Cellular And Molecular Life Sciences] |
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| Scientists human ESCs bioengineered to overexpress 18, 23, and 31 kD isoforms of fibroblast growth factor 2, were used in combination with reimplantation of the avulsed roots using heterologous fibrin biopolymer.
[Stem Cell Research & Therapy] |
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| The authors showed that protein tyrosine phosphatase 1B (PTP1B) inhibited intracellular signaling and dampens iNeutrophil effector function.
[Journal Of Leukocyte Biology] |
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| Investigators generated iPSCs derived from familial Parkinson’s disease patients carrying SNCA A53T mutation, differentiating them into cortical neurons by a direct conversion method.
[Molecular Brain] |
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| Researchers generated a human iPSC line from the peripheral blood mononuclear cells isolated from a 59-year-old male patient with Alzheimer’s disease.
[Stem Cell Research] |
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| iPSC line SDQLCHi029-A was successfully generated from peripheral blood mononuclear cells obtained from a five-day-old girl with melanocortin-2-receptor (MC2R) mutations
[Stem Cell Research] |
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| The authors describe recent advances in developing kidney organoids and organ-chips by harnessing iPS cell biology to model human-specific kidney functions and disease states. They also discuss challenges that must be overcome to realize the potential of organoids and organ-chips as conduits of the human kidney.
[Annual Review Of Biomedical Engineering] |
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| | Scientists have finally managed to put elephant skin cells into an embryonic state. The breakthrough — announced by the de-extinction company Colossal Biosciences in Dallas, Texas — is an early technical success in Colossal’s high-profile effort to engineer elephants with woolly mammoth traits.
[Nature] |
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| A Phase I/IIa clinical trial evaluating TED-A9, a human stem cell-based therapy, in people with Parkinson’s disease has finished dosing with no safety concerns identified to date.
[Parkinson’s News Today] |
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| April 7 – 10, 2024
San Diego, California, United States |
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| | King’s College London – London, England, United Kingdom |
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| | University of Bristol – Bristol, England, United Kingdom |
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| | King’s College London – London, England, United Kingdom |
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| | University of Amsterdam – Amsterdam, Netherlandsipsc |
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