 | | Vol. 19.09 – 13 March, 2024 |
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| Researchers revealed that H2AK119ub1 had two distinct roles in gene expression, through differentially modulating chromatin compaction mediated by canonical polycomb repressive complex 1 (PRC1) and the linker histone H1.
[Molecular Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that argonaute (AGO) 1 controlled cell fate decisions through facilitating protein folding. They found that in mESCs, while AGO2 facilitated differentiation via the miRNA pathway, AGO1 controlled stemness independently of its binding to small RNAs.
[Developmental Cell] |
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| Investigators demonstrated that macroautophagy/autophagy-related protein ATG5 inhibited the inflammatory response of mouse ESCs by promoting the degradation of BTRC/β-TrCP1 and further the downregulation of NFKB/NF-κB signaling.
[Autophagy] |
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| The authors established a method to generate PSC-derived skin organoids effectively in a chemically-defined 3D extracellular matrix environment.
[Advanced Healthcare Materials] |
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| Scientists applied unidirectional shear stress to promote hiPSCs differentiation into valvular endothelial-like (VELs) cells. They found that Piezo1 served as a crucial mechanosensor for the differentiation and maturation of VELs.
[Acta Biomaterialia] |
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| Researchers focused on the characterization of the genetic traits and alterations in pluripotency/stemness triggered by phthalate ester derivatives. They reported the abilities of ESCs regarding proliferation, cell-cycle control, and neural ectoderm differentiation.
[Environmental Pollution] |
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| Investigators used Moloney murine leukemia virus (MLV) to explore the role of Smarcad1 in retroviral silencing in ESCs. They showed that Smarcad1 was immediately recruited to the MLV provirus.
[Mobile DNA] |
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| Scientists increased the efficiency of generating cardiomyocytes from hPSCs. They identified cell death as a detrimental factor during this initial stage of in vitro cardiomyocyte differentiation.
[Regenerative Therapy] |
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| Researchers harvested cells on days 0, 5, 10, 15, and 20 to analyze for various sarcomeric tropomyosin (TPM) transcripts by qRT-PCR and for sarcomeric TPM proteins using two-dimensional (2D) Western blot with sarcomeric TPM-specific CH1 monoclonal antibody followed by mass spectra analyses.
[Cytoskeleton] |
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| The authors review the evidence of cellular senescence in neuronal aging and disease, discuss hPSC-based model systems used to investigate neuronal senescence, and propose a panel of cellular and molecular hallmarks to characterize senescent neurons.
[Nature Aging] |
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| Investigators discuss recent advances in the generation and applications of using human–animal chimeric brain models for the study of neurological disorders, including disease modeling and cell therapy.
[Neuroscience Bulletin] |
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| Powered by a $4 million grant from the California Institute for Regenerative Medicine, Gladstone will expand its capabilities even further by establishing a center for stem cell disease modeling and CRISPR drug screening.
[Gladstone Institutes] |
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| April 14 – 17, 2024
Glasgow, Scotland, United Kingdom |
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| | St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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| | French National Institute for Health Research (INSERM) – Nantes, France |
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| | King’s College London – London, England, United Kingdom |
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| | University of Bristol – Bristol, England, United Kingdom |
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Cancer Stem Cell News
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