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Vol. 19.10 – 20 March, 2024
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Scientists found that there was a remarkable reorganization of 3D genome structure where inter-chromosomal intermingling increased dramatically in the formative state.
[Molecular Cell]
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PUBLICATIONSRanked by the impact factor of the journal
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The authors investigated how precise and reproducible patterns of gene expression emerged in mammals by using gastruloids, a three-dimensional (3D) in vitro model for early mammalian development.
[Nature Structural & Molecular Biology]
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Researchers applied three scoring indexes of entropies, cell-type signature transcription factor expression, and critical transition signals to show common features underpinning the fate plasticity of transition states.
[Developmental Cell]
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Scientists revealed the novel functions of mouse Txnip in cellular reprogramming and differentiation onset by involving in glucose-mediated histone acetylation and the regulation of Oct4, which was a fundamental component of the molecular circuitry underlying pluripotency.
[Cellular and Molecular Life Sciences]
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Investigators reported that, proline dehydrogenase (PRODH), a mitochondria-localized proline metabolism enzyme, was dramatically upregulated in naive hESCs compared to their primed counterparts.
[EMBO Reports]
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Transcriptome, differentiation marker protein detection and parathyroid hormone secretion assays were performed after the completion of the in vitro differentiation of parathyroid-like cells.
[Cell Proliferation]
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Researchers created a novel SOX10-P2A-mOrange iPSC reporter line to track and purify oligodendrocyte precursor cells.
[Glia]
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The authors established and validated an in-house platform to produce GMP-compliant hiPSCs that would be appropriate for producing both allogeneic and autologous hiPSC-derived products.
[Cytotherapy]
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Investigators reported that P53 and its pro-apoptotic target PUMA and NOXA regulated apoptosis susceptibility and competitive fitness in pluripotent cells. PUMA was widely expressed specifically in pluripotent cells in vitro and in vivo.
[PLOS Genetics]
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The use of both organoids and spheroids, derived from either hESCs or hiPSCs would allow identification of cell type-specific changes associated with anorexia nervosa and comorbid diseases, to study preferential connections between brain areas and organs.
[Trends in Molecular Medicine]
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Scientists at the University of Wisconsin-Madison have spent years trying to unravel the details of Down syndrome: What happens inside the womb, how the genetic disorder alters the formation of neurons, and what specific processes affect brain development. The work can’t proceed without studying fetal tissue.
[STAT News]
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April 22 – 25, 2024
Baltimore, Maryland, United States
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NYU Langone Health – New York City, New York, United States
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St. Anna Children’s Cancer Research Institute – Vienna, Austria
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French National Institute for Health Research (INSERM) – Nantes, France
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King’s College London – London, England, United Kingdom
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Cancer Stem Cell News
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