 | | Vol. 19.11 – 27 March, 2024 |
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To better understand the role of H3K4me1 in enhancer function, the authors analyzed dynamic enhancer-promoter interactions and gene expression during neural differentiation of the mESCs.
[Molecular Cell] |
|  | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that the modification of H3K18la induced by Dux overexpression controlled the metabolism-H3K18la-MET network, enhancing the efficiency of iPSC reprogramming through a metabolic switch and the recruitment of p300 via its C-terminal domain.
[Nucleic Acids Research] |
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| To substantiate the clinical application of astrocyte-based therapy, researchers prepared human astrocytes with potent therapeutic capacities from hPSCs. They used ventral midbrain patterning during the differentiation of hPSCs into astrocytes.
[Journal of Advanced Research] |
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| Stirred tank bioreactors-controlled, chemical aggregate dissociation, and optimized passage duration of three or four days promoted exponential hPSC proliferation, process efficiency, and upscaling by a seed train approach.
[Stem Cell Research & Therapy] |
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| Using single-cell RNA sequencing, researchers investigated transcription factors expressed in endothelial progenitors (EPs) derived from hPSCs and identified upregulated expression of SOXF factors SOX7, SOX17, and SOX18 in the EP population.
[Stem Cell Reports] |
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| Investigators cultured hPSCs on hydrogel substrates with spatially controlled stiffness. The use of culture substrates that enabled precise manipulation of spatial mechanical properties held promise for better mimicking in vivo conditions and advancing tissue engineering techniques.
[Development] |
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| Scientists evaluated the efficiency of cryopreservation using DEPAK and Proton freezers, both of which are used in the food industry, compared with conventional slow-freezing methods using a programmable freezer and a cell-freezing vessel.
[Regenerative Therapy] |
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| The authors revealed the pivotal role of RNA-binding motif protein 46 (RBM46) in ESCs, acting as a direct post transcriptional regulator of ROS levels by modulating BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3) mRNA expression.
[Biochemical and Biophysical Research Communications] |
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| Neuromesodermal progenitors (NMPs) derived from iPSCs were used to collect conditioned medium. Fibroblast derived iPSCs were successfully differentiated into NMPs and NMPs were characterized by double positive T/Bra and Sox2 staining.
[Molecular Biology Reports] |
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| Scientists evaluate the current state-of-the-art regarding in vitro cell culture models of dental epithelium and ameloblast lineage with a particular focus toward their applicability for translational tissue engineering and regenerative/personalized medicine.
[Stem Cell Reviews and Report] |
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| Investigators review the current state of knowledge surrounding the cellular mechanisms of inherited arrhythmias generated from stem cell models with a focus on integrating genetic and mechanistic data.
[Nature Cardiovascular Research] |
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| UMass Chan Medical School and Lahey Hospital & Medical Center have signed a research affiliation agreement to create a new quantitative science research hub to improve health outcomes and disparities through population health, digital medicine, and health systems science.
[UMass Chan Medical School] |
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| April 24 – 26, 2024
Vienna, Austria |
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| | Sapienza University – Rome, Italy |
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| | NYU Langone Health – New York City, New York, United States |
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| | St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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| | French National Institute for Health Research (INSERM) – Nantes, France |
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