 | | Vol. 19.13 – 10 April, 2024 |
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| The authors engineered hiPSC-derived neuronal lines to express 4R Tau and 4R Tau carrying the P301S MAPT mutation when differentiated into neurons.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using the post-implantation amniotic sac embryoid, scientists delineated basement membrane (BM) assembly upon post-implantation development and BM disassembly during primitive streak cell dissemination.
[Developmental Cell] |
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| Investigators combined continuous Cas9-based molecular recording with a mESC-based model of the embryonic trunk to build single-cell phylogenies that described the behavior of transient, multipotent neuro-mesodermal progenitors as they committed into neural and somitic cell types.
[Developmental Cell] |
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| Scientists presented a comprehensive eRNA atlas by systematically integrating publicly available datasets of mouse early embryos. They characterized the transcriptional and regulatory network of eRNAs and showed that different embryo developmental stages had distinct eRNA expression and regulatory profiles.
[Cell Reports] |
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| How aneuploidy affects spatial genome organization remains poorly understood. Researchers addressed this question by utilizing the previously established isogenic wild-type and trisomic mouse embryonic stem cells
[Cell Proliferation] |
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| A modified mRNA (ModRNA)-based Activation for Gene Insertion and Knockin (MAGIK) method operated in two steps: first, it used a Cas9-2A-p53DD modRNA with a mini-donor plasmid; second a deactivated Cas9 activator modRNA and a ‘dead’ guide RNA were used to temporarily activate the targeted gene.
[Stem Cell Reports] |
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| To explore the role of the N6-methyladenosine (m6A) modification in pluripotent reprogramming, scientists used RNA-seq to map m6A effectors in human iPSCs, fibroblasts, and H9 ESCs, as well as in mESCs and fibroblasts.
[Human Genomics] |
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| The authors cultured iPSCs on tissue culture plastic and polydimethylsiloxane with different Young’s modulus to investigate the sequel on growth and differentiation toward endoderm, mesoderm, and ectoderm.
[Cytotherapy] |
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| Scientists generated iPSC lines from two patients with central core disease and malignant hyperthermia caused by dominant RYR1 variants within the central region of the protein.
[Stem Cell Research] |
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| Investigators highlight successes from some of the hPSC-based trials reporting early signs of efficacy and discuss common challenges in the clinical translation of cell therapies.
[Development] |
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| Ten years after the STAP stem cell scandal, structural problems that led to the scandal persist, leaving ample room for researchers to tamper with research data, experts say.
[The Japan Times] |
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| May 29 – June 1, 2024
Vancouver, British Columbia, Canada |
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| | Emory University – Atlanta, Georgia, United States |
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| | Harvard University – Cambridge, Massachusetts, United States |
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| | Sapienza University – Rome, Italy |
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| | NYU Langone Health – New York City, New York, United States |
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