 | | Vol. 19.15 – 24 April, 2024 |
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| To understand how metabolism impacted early mesoderm development, scientists used mESC-derived gastruloids, that co-expressed glucose transporters with the mesodermal marker T/Bra.
[Developmental Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors developed a method to capture and sequence newly synthesized RNA in early mouse embryos, providing a view of transcriptional reprogramming during zygotic genome activation.
[Cell Reports] |
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| Researchers delineated the dynamics of TFAP2C during the mouse peri-implantation stage and elucidated its collaboration with the key lineage regulators CDX2 and NANOG.
[Cell Reports] |
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| Scientists generated retinal organoids from iPSCs derived from patients with eyes shut homolog (EYS)-associated retinal dystrophy.
[JCI Insight] |
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| Researchers reported that human umbilical cord blood and murine bone marrow purified VSELs expressed mRNA for P1 and P2 purinergic receptors and CD39 and CD73 ectonucleotidases converting extracellular ATP into its signaling metabolite extracellular adenosine.
[Stem Cell Reviews And Reports] |
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| Chromatin organization between mESCs, newborn lens epithelium, and fiber cells were analyzed using Hi-C. Localization of CTCF in both lens chromatins was determined by ChIP-seq and compared with ESCs.
[Epigenetics & Chromatin] |
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| Investigators showed that the overexpression of transducin-β-like protein 1 (Tbl1) or its family member Tblr1 could decrease Tcf7l1 protein levels, while the knockdown of each increased Tcf7l1 levels without affecting Tcf7l1 transcription.
[Journal of Cell Science] |
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| The authors utilized published single-cell RNA sequencing data from a Dux-mediated mESCs to induce a 2-cell-like transition state and selected potential drivers for the transition according to an RNA velocity analysis.
[Molecular Biology Reports] |
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| Scientists discuss the role of canonical signaling pathways implicated in the regulation of pluripotency and differentiation particularly in mouse and human ESCs.
[Cellular Reprogramming] |
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| Researchers in Canada got most of what they were hoping for in the country’s 2024 federal budget, with a big boost in postgraduate pay and more funding for research and scientific infrastructure.
[Nature] |
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| May 31 – June 4, 2024
Chicago, Illinois, United States & Online |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Harvard Medical School and Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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