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| Investigators constructed a 3D model of the CS8 embryo, in which a range of cell subtypes were identified, based on gene expression patterns and positional register, along the anterior-posterior, medial-lateral, and dorsal-ventral axis in the embryo.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists presented a precise and programmable method called prime editor–mediated correction of nucleotide repeat expansion for correcting pathogenic nucleotide repeat expansion.
[Nucleic Acids Research] |
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| A system was described for differentiating hiPSCs on new generation laminin fragments, a recombinant form of a laminin E8 fragment conjugated to the heparan sulfate chains attachment domain of perlecan.
[Advanced Science] |
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| Researchers examined mESC lines with an inducible Xist allele and integrated allele-specific data of gene silencing and decreasing inactive X chromatin accessibility over time courses of Xist induction with cellular differentiation.
[EMBO Reports] |
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| The authors showed that Entropy Sorting provided an alternative mathematical framework for feature selection. On synthetic datasets, continuous entropy sort feature weighting outperformed highly variable gene selection in distinguishing cell state specific genes.
[Development] |
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| Given that the equivalence of hESCs and hiPSCs remained controversial, investigators compared the molecular and functional equivalence of hESC- and hiPSC-derived Schwann cells generated with a previously reported protocol.
[iScience] |
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| Scientists demonstrated that a combination of p53 inhibition and pro-survival small molecules achieved a homologous recombination rate higher than 90% using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) in human iPSCs.
[Scientific Reports] |
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| The authors showed that serine/arginine repetitive matrix 2 (Srrm2) dosage was critical for maintaining ESC pluripotency and cell identity.
[Biology Open] |
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| Scientists outline key developments in the iPSC field and highlight the immense versatility of the iPSC technology for in vitro modeling and therapeutic applications.
[Signal Transduction and Targeted Therapy] |
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| Investigators review the progress of haploid ESC research and briefly discuss the applications of haploid ESCs.
[Stem Cell Research & Therapy] |
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| Executive Yuan approved the Ministry of Health and Welfare’s draft bills for a regenerative medicine act and a regenerative pharmaceuticals act.
[Overseas Community Affairs Council, Republic of China] |
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| June 5 – 8, 2024
Milan, Italy |
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| | NovoNordisk – Beijing, China |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Harvard Medical School and Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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