TOP STORY A Better Way to Grow Stem Cells Researchers have devised a synthetic surface that includes no foreign animal material and allows stem cells to stay alive and continue reproducing themselves for at least three months. [Press release from the Massachusetts Institute of Technology discussing online prepublication in Nature Materials]
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SCIENCE NEWS Stem Cells from the Thymus Reprogrammed to Become Skin Stem Cells The study shows that stem cells from the thymus can function as hair follicle stem cells and contribute to the long-term maintenance of the skin. [Press release from the Medical Research Council Centre for Regenerative Medicine discussing online prepublication in Nature] Stem Cell First Researchers have created induced pluripotent stem cells from human skin without the use of viruses or genetic manipulation, an important step toward their eventual use in treating human disease. [Press release from the University of New South Wales discussing online prepublication in PLoS One]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Microenvironmental Reprogramming of Thymic Epithelial Cells to Skin Multipotent Stem Cells Researchers show that the thymus of the rat contains a population of clonogenic thymic epithelial cells that can be extensively cultured while conserving the capacity to integrate in a thymic epithelial network and to express major histocompatibility complex class II molecules and Aire. [Nature] Combinatorial Development of Biomaterials for Clonal Growth of Human Pluripotent Stem Cells Researchers develop the first chemically defined, xeno-free, feeder-free synthetic substrates to support robust self-renewal of fully dissociated human embryonic stem and induced pluripotent stem cells. [Nat Mater] Female Human iPSCs Retain an Inactive X Chromosome Results indicate that human induced pluripotent stem cells (iPSCs) are epigenetically dynamic and do not display a pristine state of X inactivation with two active Xs as found in some female human embryonic stem cell lines. [Cell Stem Cell] Canonical Wnt/Beta-Catenin Regulation of Liver Receptor Homolog-1 (Lrh-1) Mediates Pluripotency Gene Expression Researchers present genetic, molecular, and pharmacological studies identifying a signaling axis in which beta-catenin promotes pluripotency gene expression in an Lrh-1-dependent manner. [Stem Cells] High-Efficiency Induction of Neural Conversion in hESCs and hiPSCs with a Single Chemical Inhibitor of TGF-Beta Superfamily Receptors Researchers identified compound C (also denoted as dorsomorphin), a protein kinase inhibitor, as a potent regulator of human embryonic stem cell (hESC) and human induced pluripotent stem cell (hiPSC) fate decisions. [Stem Cells] A Role for Regulatory T Cells in Acceptance of Embryonic Stem Cell-Derived Tissues Transplanted Across an MHC Barrier Researchers demonstrate that fully allogeneic embryonic stem cell-derived tissues are accepted with a regimen of coreceptor blockade even in recipients known to be relatively resistant to such a tolerizing protocol. [Stem Cells] Generation of Microglial Cells from Mouse Embryonic Stem Cells Researchers describe a basic protocol for the in vitro differentiation of mouse embryonic stem cells into microglial precursor cells. [Nat Protoc] Factors from Human Embryonic Stem Cell-Derived Fibroblast-Like Cells Promote Topology-Dependent Hepatic Differentiation in Primate Embryonic and Induced Pluripotent Stem Cells Researchers describe a novel in vitro differentiation model, and show that human embryonic stem cell (ESC)-derived fibroblast-like cell-secreted factors act in concert with regional features of ESC colonies to induce robust hepatic endoderm differentiation in primate pluripotent stem cells. [J Biol Chem] A Combined Epigenetic and Non-Genetic Approach for Reprogramming Human Somatic Cells Researchers report the first application of a combined epigenetic and non-genetic approach for reprogramming somatic cells, i.e., DNA methyltransferase and histone deacetylase inhibitors, and human embryonic stem cell extracts. [PLoS One] Dynamic MicroRNA Expression Programs During Cardiac Differentiation of Human Embryonic Stem Cells: Role for miR-499 The data give significant insight into the regulatory networks that govern human embryonic stem cell (hESC) differentiation, and highlights the ability of microRNAs to perturb, and even control, the genes that are involved in cardiac specification of hESCs. [Circ Cardiovasc Genet]
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POLICY NEWS Federal Judge: Obama Stem Cell Policy Halted Research on embryonic stem cells funded by the U.S. government must stop immediately for a court-ordered review, Judge Royce Lamberth of the U.S. District Court for the District of Columbia ruled. [United States District Court for the District of Columbia] NIH Director Collins Says Cell Ruling Won’t Halt Most Ongoing Grants National Institutes of Health (NIH) Director Francis Collins said that the court injunction blocking federally funded research on human embryonic stem cells will not affect grant payments that have already gone out the door this year. [National Institutes of Health, United States] Universities, Scientists Urge NIH to Narrow Conflicts Rule The biomedical research community is reacting with concern to a proposal from the National Institutes of Health (NIH) to clamp down on financial conflicts of interest in research. [National Institutes of Health, United States] Lawrence A. Tabak Named Principal Deputy Director NIH National Institutes of Health Director Francis S. Collins, M.D., Ph.D., announced the appointment of Lawrence A. Tabak, D.D.S., Ph.D., as principal deputy director of the National Institutes of Health. [National Institutes of Health, United States] Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical Practice; Public Workshop [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States] Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) (R01) (RFA-GM-11-003) [National Institutes of Health, United States] NIH-RAID Updates on Program Scope and Procedures: Biologics Manufacture, Lead Selection, and Product Development Plans (NOT-RM-10-012) [National Institutes of Health, United States] Proposed Collection; Comment Request; STAR METRICS–Science and Technology in America’s Reinvestment: Measuring the Effects of Research on Innovation, Competitiveness and Science (FR Doc. 2010-20614) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-20588) [National Institutes of Health, United States] Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-20675) [National Institutes of Health, United States] Support of National Institute of General Medical Sciences Program Project Grants (P01) (PAR-10-266) [National Institutes of Health, United States] Limited Pilot for National Institute of General Medical Sciences Legacy Community-Wide Scientific Resources (R24) (PAR-10-261) [National Institute of General Medical Sciences, United States] Submission for Office of Management and Budget Review; Comment Request; Resource for the Collection and Evaluation of Human Tissues and Cells from Donors With an Epidemiology Profile (NCI) (FR Doc. 2010-21098) [National Institutes of Health, United States]
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EVENTS International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting September 11-14, 2010 Belgirate, Italy Hydra VI: The European Summer School on Stem Cells & Regenerative Medicine September 11-17, 2010 Hydra, Greece Stem Cells USA & Regenerative Medicine Congress 2010 September 13-15, 2010 Philadelphia, United States Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010 September 15-17, 2010 Sydney, Australia 5th Annual Meeting of the German Society for Stem Cell Research September 30-October 2, 2010 Lübeck, Germany 5th World Congress on Preventive & Regenerative Medicine (WCRM) 2010 October 5-7, 2010 Hannover, Germany Induced Pluripotent Stem Cells: Production and Utility in Regenerative Medicine October 7, 2010 Hertfordshire, United KingdomFraunhofer Life Science Symposium Leipzig 2010 October 29-30, 2010 Leipzig, Germany BioMalaysia 2010 Conference and Exhibition November 2-4, 2010 Kuala Lumpur, Malaysia Select Biosciences 2nd International Forum on Stem Cells November 12-13, 2010 Tianjin, China Stem Cell Network 10th Annual Scientific Meeting November 22-24, 2010 Calgary, Canada Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference December 5-8, 2010 Orlando, United States Biotech Showcase 2011 January 10-12, 2011 San Francisco, United States Stem Cells World Congress January 24-25, 2011 San Diego, United States Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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