Grafted Human-Induced Pluripotent Stem-Cell–Derived Neurospheres Promote Motor Functional Recovery After Spinal Cord Injury in Mice Here, researchers investigated the therapeutic potential of transplanting human-induced pluripotent stem cell-derived neurospheres into nonobese diabetic-severe combined immunodeficient mice to treat spinal cord injury. [Proc Natl Acad Sci U S A] Abstract Modeling Abnormal Early Development with Induced Pluripotent Stem Cells from Aneuploid Syndromes Here investigators aimed to produce induced pluripotent stem cell lines that can be used to improve the understanding of aneuploid syndromes. [Hum Mol Genet] Abstract Human Pompe Disease Induced Pluripotent Stem Cells for Pathogenesis Modeling, Drug Testing and Disease Marker Identification Here, scientists report the derivation of Pompe disease induced pluripotent stem cells from two patients with different GAA mutations and their potential for pathogenesis modeling, drug testing and disease marker identification. [Hum Mol Genet] Abstract Mobilization of Giant piggyBac Transposons in the Mouse Genome Here, researchers show that the DNA transposon piggyBac can mobilize 100-kb DNA fragments in mouse embryonic stem cells, making it the only known transposon with such a large cargo capacity. [Nucleic Acids Res] Abstract miRNA Screening Reveals a New miRNA Family Stimulating iPS Cell Generation via Regulation of Meox2 By conducting a microRNA (miRNA) library screen, investigators identified a set of miRNAs critically regulating induced pluripotent stem cell (iPSC) formation. [EMBO Rep] Abstract Maintenance of Human Embryonic Stem Cells in Mesenchymal Stem Cell-Conditioned Media Augments Hematopoietic Specification Here, researchers hypothesized that human embryonic stem cells (hESCs) maintained in human mesenchymal stem cell-conditioned media may be more prone to differentiation towards hematopoietic lineage than hESCs grown in standard human foreskin fibroblast-conditioned media. [Stem Cells Dev] Abstract Primitive Cardiac Cells from Human Embryonic Stem Cells In this study, investigators have developed a differentiation protocol that minimizes the need for specific human embryonic stem cell line optimization. [Stem Cells Dev] Abstract Optimization of Protocols for Derivation of Mouse Embryonic Stem Cell Lines from Refractory Strains, Including the Non-Obese Diabetic Mouse Here, researchers report the development of protocols for the derivation of novel embryonic stem cell (ESC) lines from C57Bl/6 mice based on the combined use of high concentrations of leukemia inhibitory factor and serum-replacement, which is equally applicable to fresh and cryo-preserved embryos. [Stem Cells Dev] Abstract |