Extracellular Matrix Cell News Volume 11.29 | Jul 30 2020

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    Extracellular Matrix Cell News 11.29 | July 30 2020


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 11.29 – 30 July, 2020
    TOP STORY

    Mutations in COMP Cause Familial Carpal Tunnel Syndrome

    Researchers report the identification of two mutations in cartilage oligomeric matrix protein that segregated with carpal tunnel syndrome in two large families with or without multiple epiphyseal dysplasia.
    [Nature Communications]

    Full Article

    Watch 'collaborating to accelerate COVID-19 research'
    PUBLICATIONSRanked by the impact factor of the journal

    Basement Membrane Damage by ROS- and JNK-Mediated Mmp2 Activation drives Macrophage Recruitment to Overgrown Tissue

    Investigators utilize an overgrowth tumor model in larval Drosophila imaginal discs that are attached by numerous macrophages. They report that changes to the microenvironment of the overgrown tissue were important for recruiting macrophages.
    [Nature Communications]

    Full Article

    Pan-Cancer Analysis of the Genomic Alterations and Mutations of the Matrisome

    Mining The Cancer Genome Atlas data, scientists found that copy number alterations and mutations are frequent in matrisome genes, even more so than in the rest of the genome.
    [Cancers]

    Full ArticleGraphical Abstract

    Extracellular Cold-Inducible RNA-Binding Protein Regulates Neutrophil Extracellular Trap Formation and Tissue Damage in Acute Pancreatitis

    Scientists studied the role of extracellular cold-inducible RNA-binding protein, a novel damage-associated-molecular-pattern molecule, in severe acute pancreatitis.
    [Laboratory Investigation]

    Abstract

    Microfibril-Associated Glycoprotein 4 (Mfap4) Regulates Hematopoiesis in Zebrafish

    Researchers suggested that loss of ECM protein, Mfap4, alters the balance between myeloid and lymphoid lineages during both primitive and definitive hematopoiesis, which could significantly impact the downstream function of the immune system.
    [Scientific Reports]

    Full Article

    Pro-Angiogenic Scaffold-Free Bio Three-Dimensional Conduit Developed from Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Promotes Peripheral Nerve Regeneration

    Researchers investigated the efficacy and mechanism of the Bio 3D conduit composed of xeno-free human induced pluripotent stem cell–derived mesenchymal stem cells.
    [Scientific Reports]

    Full Article

    Structure of a Collagen VI α3 Chain VWA Domain Array: Adaptability and Functional Implications of Myopathy Causing Mutations

    Collagen VI is a ubiquitous heterotrimeric protein of the ECM that plays an essential role in the proper maintenance of skeletal muscle. Scientists investigated structure-function relationships of N2 domain mutations to shed light on their possible myopathy mechanisms.
    [Journal of Biological Chemistry]

    Abstract

    Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis

    Fibrosis, or the accumulation of ECM, is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, scientists cross-examined human primary cells from various tissues treated with TGF-β, as well as kidney and liver fibrosis models.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Five tips for returning to the lab after time off
    REVIEWS

    Targeting CD39 in Cancer

    The authors review the impact of CD39 expression and ectonucleotidase activity on immunity with a focus on the setting of oncology.
    [Nature Reviews Immunology]

    Abstract

    TGFβ Biology in Cancer Progression and Immunotherapy

    Scientists introduce the mechanisms underlying TGFβ signaling in tumors and their microenvironment and discuss approaches to inhibit these signaling mechanisms as well as the use of these approaches in cancer immunotherapies and their potential adverse effects.
    [Nature Reviews Clinical Oncology]

    Abstract

    Epigenetics in Modulating Immune Functions of Stromal and Immune Cells in the Tumor Microenvironment

    The authors review recent studies demonstrating how specific epigenetic mechanisms drive aspects of stromal and immune cell differentiation with implications for the development of solid tumor therapeutics, focusing on the pancreatic ductal adenocarcinoma tumor microenvironment as a representative of solid tumors.
    [Cellular & Molecular Immunology]

    Abstract

    INDUSTRY AND POLICY NEWS

    The Trump Administration Must Stop Sidelining the CDC

    As deaths from COVID-19 approach 150,000 in the United States and cases continue to rise alarmingly in many regions of the country, there are strong signs that the government is suppressing a public-health approach to controlling the pandemic.
    [Nature News]

    Editorial

    ‘Vaccine Nationalism’ Threatens Global Plan to Distribute COVID-19 Shots Fairly

    As soon as the first COVID-19 vaccines get approved, a staggering global need will confront limited supplies. Many health experts say it’s clear who should get the first shots: health care workers around the world, then people at a higher risk of severe disease, then those in areas where the disease is spreading rapidly, and finally, the rest of us.
    [ScienceInsider]

    Editorial

    Foreign Researchers Accused of Hiding Links to Chinese Military

    Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China.
    [The Scientist]

    Editorial

    FEATURED EVENT

    3D Hybrid Organotypic Systems

    February 28 – March 3 2021
    Schöntal Monastery, Germany

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Novel Immunotherapy

    University of Mississippi School of Pharmacy – Oxford, Mississippi, United States

    Research Fellow – Neural Cell Therapy

    Nanyang Technological University – Singapore, Singapore

    Research Fellow – Biophysical Cell Analysis and Sorting Instrumentation

    Nanyang Technological University – Singapore, Singapore

    Research Associate – Morphogen Dynamics

    TU Dresden – Dresden, Germany

    Research Group Leader – Senescence and Healing of Wounds

    Ludwig Boltzmann Gesellschaft GmbH – Vienna, Austria

    > See All Jobs

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