 | | Vol. 11.31 – 13 August, 2020 |
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| Researchers showed that the extended intratumoral release of the STING agonist cyclic di-AMP transformed the tumor microenvironment from immunosuppressive to immunostimulatory, increasing the efficacy of antitumor therapies.
[Nature Biomedical Engineering] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators demonstrated a hydrogel design using tandem-repeat proteins as the cross-linkers and random coiled polymers as the percolating network.
[Nature Communications] |
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| Scientists demonstrated that Mex3a knockdown significantly inhibited lung adenocarcinoma cell migration and invasion in vitro and metastasis in nude mice. Transcriptome sequencing indicated that Mex3a affected gene expression linked to ECM-receptor interactions, including laminin subunit alpha 2.
[Cell Death & Disease] |
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| Neural ribbons offer multifunctionality in vitro including co-encapsulation of the injury site ECM modifier chondroitinase ABC, tested in glial scar models, and ability of cervically-patterned spinal cord neural stem cells to differentiate within neural ribbons and project axons for integration with 3D external matrices.
[Scientific Reports] |
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| Scientists present ScAffoLd SimulAtor (SALSA), a general purpose computational tool that can simulate the behavior of a population of cells cultured in a 3D scaffold.
[Scientific Reports] |
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| The authors outlined the multifactorial character of snake venom metalloproteinases (SVMP)-induced tissue damage, including the transient activation of tissue proteinases, and underscored for the first time that endothelial glycocalyx proteoglycans and PDGFR are targets of SVMPs in the disruption of microvasculature integrity and generation of hemorrhage.
[Scientific Reports] |
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| Investigators successfully fabricated a novel antibacterial nanofiber mat (ethyl cellulose/poly lactic acid/collagen) incorporated with silver sulfadiazine and then analyzed with the required tests.
[International Journal of Biological Macromolecules] |
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| The authors investigated the incorporation of cell-seeded poly-L-lactide-co-glycolide scaffolds in hypertensive and nonhypertensive mice. Collagen-coated scaffolds were seeded with osteoblast-like and mesenchymal stem cells.
[Hypertension Research] |
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| Investigators describe self-replicating RNAs encapsulated in lipid nanoparticles (LNPs), which combined three key elements: an LNP composition that potently promoted immunogenic cancer cell death, RNA that stimulated danger sensors in transfected cells and RNA-encoded interleukin (IL)-12 for modulation of immune cells.
[Nature Cancer] |
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| Scientists suggest that lipoedema is an estrogen-dependent disorder of adipose tissue, which is triggered by a dysfunction of caveolin 1 (CAV1) and subsequent uncoupling of feedback mechanisms between CAV1, the matrix metalloproteinase MMP14 and estrogen receptors.
[Nature Reviews Endocrinology] |
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| The authors aim to understand the biological processes, key events, and consequences regarding the hypoxia-driven metabolic adaptation of tumor cells.
[International Journal of Molecular Sciences] |
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| GeneCentric Therapeutics has announced entering into a research collaboration with Janssen Research & Development, LLC around RNA-based drug response biomarkers for non-muscle invasive bladder cancer. The research will involve the application of GeneCentric’s advanced RNA-based molecular profiling platform to elucidate potential signatures of disease progression and drug response to standard of care therapy, including the role of genomic alterations in the fibroblast growth factor receptor.
[GeneCentric Therapeutics (Businesswire Inc.)] |
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| November 2 – November 3
Virtual |
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| | Heidelberg Institute for Stem Cell Technologies and Experimental Medicine – Heidelberg, Baden-Württemberg, Germany |
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| | Northwestern University – Chicago, Illinois, United States |
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| | United Therapeutics – Silver Spring, Maryland, United States |
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| | The University of Tennessee Health Science Center (UTHSC) – Memphis, Tennessee, United States |
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| | University of Mississippi School of Pharmacy – Oxford, Mississippi, United States |
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