 | | Vol. 11.34 – 3 September, 2020 |
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| Scientists used computational modeling, genetic manipulations and biophysical measurements to identify the biophysical underpinnings and biological consequences of tumor architectures.
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors report that developmental anoikis distinguished the pathological detachment of progenitor cells from the normal delamination of daughter neuroblasts in the developing mouse neocortex.
[Nature Communications] |
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| Scientists developed a method to generate heart organoids from mouse embryonic stem cell-derived embryoid bodies.
[Nature Communications] |
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| To characterize tumor-infiltrating T regulatory cells (Tregs), researchers performed bulk RNA sequencing and found that proliferation-related genes, immune suppression-related genes, and cytokine/chemokine receptor genes were upregulated in tumor-infiltrating Tregs compared to tumor-infiltrating CD4+Foxp3− conventional T cells or splenic Tregs from the same tumor-bearing mice.
[Cancer Immunology Research] |
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| Investigators cultured hormone receptor-positive breast cancer and prostate cancer spheroids and patient-derived organoids in 3D extracellular matrices alone or together with bone marrow stromal cells.
[Cancer Research] |
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| Researchers developed a matrigel-based hydrogel culture system to determine the roles of matrix stiffness and mechanotransduction in cardiac reprogramming. They found that soft matrix comparable with native myocardium promoted the efficiency and quality of cardiac reprogramming.
[Stem Cell Reports] |
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| The authors suggested that the tumor immune microenvironment of metastatic tumors was less immunologically active compared to that of primary tumors in gastric cancer patients.
[Scientific Reports] |
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| Scientists analyzed whether decellularized ECMs supported the cardiac differentiation of CardiopoieticAF stem cells. These perinatal stem cells, which can be easily isolated without ethical or safety limitations, displayed a high cardiac differentiative potential.
[International Journal of Molecular Sciences] |
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| Researchers sought to design a murine arterial graft having a more favorable local mechanical environment for infiltrating cells; they used electrospinning to enclose a compliant inner core of poly(glycerol sebacate) with a stiffer sheath of poly(caprolactone) to reduce the potential for rupture.
[Tissue Engineering] |
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| To investigate the effect of ECM stiffness on hepatocyte migration and function, scientists designed an easy fabricated polyvinyl alcohol hydrogel in which stiffness could be controlled by changing the concentration of glutaraldehyde.
[Polymers] |
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| The authors evaluated the use of a human placenta-derived ECM hydrogel, HuGentra®, to support tri-lineage differentiation of human iPSCs.
[International Journal of Stem Cells] |
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| Investigators aimed to elucidate the molecular mechanisms, whereby hyaluronic acid, a main ECM component of articular cartilage, promoted the chondrogenic differentiation of human amniotic mesenchymal stem cells.
[Experimental Biology and Medicine] |
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| Pancreatic ductal adenocarcinoma is one of the most lethal solid malignancies in the world due to its insensitivity to current therapies and its propensity to metastases from the primary tumor mass. This is largely attributed to its complex microenvironment composed of unique stromal cell populations and ECM.
[Biochimica Et Biophysica Acta-Reviews On Cancer] |
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| The authors present an updated image of the tumor microenvironment with emphasis on hypoxic niche, immune microenvironment, metabolism microenvironment, acidic niche, innervated niche, and mechanical microenvironment.
[Signal Transduction and Targeted Therapy] |
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| Scientists provide a comprehensive overview of the current understanding of fibroblast growth factor (FGF) signaling and its roles in organ development, injury repair, and the pathophysiology of a spectrum of diseases, which is a consequence of FGF signaling dysregulation.
[Signal Transduction and Targeted Therapy] |
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| Gilead Sciences, Inc. has announced an agreement with Jounce Therapeutics, Inc. to exclusively license its JTX-1811 program. JTX-1811 is a monoclonal antibody targeting the CCR8 chemokine, which is designed to selectively deplete T regulatory cells in the tumor microenvironment.
[Gilead Sciences, Inc. (Businesswire, Inc.)] |
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| UroGen Pharma Ltd. has announced that the Phase II APOLLO clinical trial of a RTGel hydrogel formulation in combination with BOTOX® (onabotulinumtoxinA) intravesical instillation in patients with overactive bladder and urinary incontinence did not meet the primary endpoint
[UroGen Pharma Ltd. (Businesswire, Inc.)] |
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| Bristol Myers Squibb and Forbius have announced that they have entered into a definitive agreement under which Bristol Myers Squibb will acquire Forbius. Forbius has developed a portfolio of highly selective and potent inhibitors of TGF-beta 1 & 3, which are key mediators of immunosuppression and fibrosis.
[Bristol Myers Squibb] |
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| | University of Washington – Seattle, Washington, United States |
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| | UCLA Jonsson Comprehensive Cancer Center – Los Angeles, California, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Brigham and Women’s Hospital, Harvard Medical School – Boston, Massachusetts, United States |
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| | Pennsylvania State University – Philadelphia, Pennsylvania, United States |
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Cancer Stem Cell News
Cell Therapy News
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ESC & iPSC News
Extracellular Matrix News
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Hepatic Cell News
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