 | | Vol. 12.04 – 4 February, 2021 |
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| Researchers performed a transcriptomic analysis of the microenvironment of 4,655 diffuse large B-cell lymphomas from multiple independent cohorts and described four major lymphoma microenvironment categories that associate with distinct biological aberrations and clinical behavior.
[Cancer Discovery] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Native ECM can exhibit cyclic nanoscale stretching and shrinking of ligands to regulate complex cell–material interactions. Designing materials that allow cyclic control of changes in intrinsic ligand‐presenting nanostructures in situ can emulate ECM dynamicity to regulate cellular adhesion.
[Advanced Materials] |
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| Using lineage tracing and single-cell sequencing in encephalomyelitis, investigators determined that the majority of the fibrotic scar is derived from proliferative central nervous system (CNS) fibroblasts, not pericytes or infiltrating bone marrow-derived cells.
[Nature Neuroscience] |
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| Scientists identified a novel role for a non-myocyte-derived and TGFbeta1-induced ECM protein microfibrillar-associated protein 4 in the pathophysiology of cardiac remodeling.
[Circulation Research] |
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| Researchers found that keratinocytes adapted to increasing matrix stiffness by forming a rigid, interconnected network of keratin bundles, in conjunction with F-actin stress fiber formation and increased cell stiffness.
[Science Advances] |
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| Scientists developed a bioprinting approach to transfer spheroids into self-healing support hydrogels at high resolution, which enabled their patterning and fusion into high-cell density microtissues of prescribed spatial organization.
[Nature Communications] |
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| In patient tumors treated with neoadjuvant stereotactic body radiation therapy, investigators found upregulation of fibrosis, ECM and epithelial-to-mesenchymal transition (EMT) gene signatures, which could drive therapeutic resistance and tumor invasion.
[Cancer Research] |
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| The roles of Quasimodo underlies the positive feedback mechanism of force-dependent organization of Dumpy filaments, providing new insights into apical ECM remodeling through the unconventional interaction of zona pellucida domain proteins.
[Current Biology] |
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| Scientists demonstrated the generation of enterocyte-like cells by culturing human induced pluripotent stem cell-derived intestinal progenitor cells on a collagen vitrigel membrane.
[Stem Cell Reports] |
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| The authors observed that αVβ6 could mediate TGF-β1 bioavailability and that VTN(381–397 A.A.) could prevent TGF-β1 activation by interacting with αVβ6 in human fibroblast-like synoviocytes and increased α-smooth muscle actin 2.
[Experimental and Molecular Medicine] |
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| Focal adhesions (FAs) are flat elongated structures that mediate cell migration and link the cytoskeleton to the ECM. Along the vertical axis FAs were shown to be composed of three layers. Investigators used structured illumination microscopy to examine the longitudinal distribution of four hallmark FA proteins, which were also used as markers for these layers.
[Scientific Reports] |
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| Researchers developed and evaluated a regenerative tissue filler that was applied as a liquid to defects during breast conserving surgery prior to transitioning to a fibrillar collagen scaffold with soft tissue consistency.
[Scientific Reports] |
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| The authors highlight recent progress in precision therapeutics and drug delivery, and identify opportunities for strategies to improve the therapeutic index of cancer drugs and, consequently, clinical outcomes.
[Nature Reviews Materials] |
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| An immune cell population enriched in inflamed gut tissue is shown to play a role in driving CD44+ intestinal organoid proliferation, while also regulating ECM deposition and remodeling in a synthetic hydrogel platform.
[Nature Materials] |
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| Scientists describe intrinsic and extrinsic mechanisms driving cancer metabolism in the tumor microenvironment and how such mechanisms may be targeted therapeutically.
[Cancer Discovery] |
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| The physical microenvironment of cells plays a fundamental role in regulating cellular behavior and cell fate, especially in the context of cancer metastasis. For example, capillary deformation can destroy arrested circulating tumor cells while the dense ECM can form a physical barrier for invading cancer cells.
[iScience] |
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| Geistlich Pharma announced that the Chondro-Gide® articular cartilage cover has been granted a Breakthrough Device Designation from the FDA. Chondro-Gide® is a collagen membrane that is used in a single-step cartilage repair technique.
[Geistlich Pharma (Businesswire, Inc.)] |
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| May 17 – 21, 2021
Virtual |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | Blood Research Institute – Milwaukee, Wisconsin, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Rutgers Cancer Institute of New Jersey – Rutgers, New Jersey, United States |
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| | University of Florida – Gainesville, Florida, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
