Extracellular Matrix News Volume 14.25 | May 25 2023

    By
    lbeveridge
    -
    0
    21








    2023-05-25 | ECM 14.25


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 14.25 – 25 May, 2023
    TOP STORY

    Extracellular Matrix Educates an Immunoregulatory Tumor Macrophage Phenotype Found in Ovarian Cancer Metastasis

    Scientists identified a tumor-associated macrophage population associated with poor prognosis, interruption of the cancer immunity cycle, and tumor ECM composition.
    [Nature Communications]

    Full Article
    Guide to everything you need to know about cell separation.
    PUBLICATIONSRanked by the impact factor of the journal

    Rectifying Disorder of Extracellular Matrix to Suppress Urethral Stricture by Protein Nanofilm-Controlled Drug Delivery from Urinary Catheter

    To target the pathological state of the ECM, researchers designed a protein-based nanofilm-controlled drug delivery system and assembled it on the catheter.
    [Nature Communications]

    Full Article

    Living Microecological Hydrogels for Wound Healing

    As the hydrogel consisted of thermosensitive Pluronic F-127 and wet-adhesive polydopamine, the living microecological hydrogel could keep liquid at a low temperature while quickly solidifying and tightly adhering to the wound bed.
    [Science Advances]

    Full Article

    Mechanoepigenetic Regulation of Extracellular Matrix Homeostasis via Yap and Taz

    Researchers discovered micrometer-sized worm-shaped Endosomal Sorting Complex Required for Transport structures that stably persisted for multiple hours at the plasma membrane of macrophages, dendritic cells, and fibroblasts.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Regenerative Engineering of Long Bones Using the Small Molecule Forskolin

    Investigators engineered a composite fibrin–PLGA -sintered microsphere scaffold for the localized, short-term delivery of the osteoinductive small molecule, forskolin.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Engineering Extracellular Matrix-Bound Nanovesicles Secreted by Three-Dimensional Human Mesenchymal Stem Cells

    Extracellular vesicles from culture supernatants and matrix-bound nanovesicles were isolated from the conditioned medium or ECM respectively of 3D human mesenchymal stem cells.
    [Advanced Healthcare Materials]

    Abstract

    Multicellular Aligned Bands Disrupt Global Collective Cell Behavior

    The authors constrained valvular interstitial cell monolayers on circular protein islands to study emergent behavior in a controlled manner and demonstrated that the general patterns of cell alignment, size, and apoptosis correlated with predicted mechanical stress fields if radially increasing stiffness or contractility were used in the computational models.
    [Acta Biomaterialia]

    Full ArticleGraphical Abstract

    Giant Worm-Shaped ESCRT Scaffolds Surround Actin-Independent Integrin Cluster

    Researchers discovered micrometer-sized worm-shaped Endosomal Sorting Complex Required for Transport (ESCRT) structures that stably persisted for multiple hours at the plasma membrane of macrophages, dendritic cells, and fibroblasts.
    [Journal Of Cell Biology]

    Full Article

    Astaxanthin Inhibits Integrin α5 Expression by Suppressing Activation of JAK1/STAT3 in Helicobacter pylori-Stimulated Gastric Epithelial Cells

    Scientists investigated whether Astaxanthin (ASX) suppressed H. pylori‑induced integrin α5 expression, cell adhesion and migration, and whether ASX reduced reactive oxygen species levels and suppressed phosphorylation of JAK1/STAT3 in gastric cancer AGS cells stimulated with H. pylori.
    [Molecular Medicine Reports]

    Full Article
    Webinar on Modeling arrhythmias using hPSC-derived cardiomyocytes
    REVIEWS

    Radiation-Induced Tumor Immune Microenvironments and Potential Targets for Combination Therapy

    Investigators discuss the changes in irradiated cancer cells and immune cells in the tumor microenvironment under different radiotherapy (RT) regimens and describe existing and potential molecules that could be targeted to improve the therapeutic effects of RT.
    [Signal Transduction And Targeted Therapy]

    Full Article

    Replacing Renal Function Using Bioengineered Tissues

    The authors outline key challenges in renal replacement and examine the clinical potential, current limitations and ethical considerations of bioengineering approaches aimed at replacing renal function, including kidney decellularization and recellularization.
    [Nature Reviews Bioengineering]

    Abstract
    INDUSTRY AND POLICY NEWS

    Hepion Pharmaceuticals’ Phase II ‘ALTITUDE-NASH’ Trial Achieves Primary and Secondary Endpoints, Including Improvement in Liver Function and Multiple NASH Biomarkers

    Hepion Pharmaceuticals, Inc. announced positive topline results from its recently completed Phase II ALTITUDE-NASH clinical trial by demonstrating improved physiologic liver function and was well tolerated after four months of treatment in subjects with stage 3 or greater fibrosis based on the AGILE 3+ criteria.
    [Hepion Pharamceutricals]

    Press Release
    FEATURED EVENT

    Single Cell Biology: From Development to Cancer

    June 18 – 22, 2023
    Keystone, Colorado, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoc Position – Disordered Proteins and Extracellular Proteoglycans

    University of Copenhagen – Copenhagen, Denmark

    PhD Position – Tumor Tissue Engineering

    Universit̩ de Lausanne РLausanne, Switzerland

    Postdoctoral Fellow – Tumor Microenvironment

    Centre for Oncology and Immunology – Hong Kong, China

    Postdoctoral Position – Cellular Topography Sensing

    Institut Pasteur – Paris, France

    Postdoctoral Fellow – Cancer Biology

    Wake Forest University – Winston Salem, North Carolina, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Extracellular Matrix News Twitter