Extracellular Matrix News 13.27 | Jul 14 2022

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    2022-07-14 | ECM 13.27


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 13.27 – 14 July, 2022
    TOP STORY

    Mechanical Checkpoint Regulates Monocyte Differentiation in Fibrotic Niches

    Human monocytes cultured in stiff, elastic hydrogels showed proinflammatory polarization and differentiation towards dendritic cells, as opposed to those cultured in a viscoelastic matrix.
    [Nature Materials]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Multiscale Functional Metal Architectures by Antibody-Guided Metallization of Specific Protein Assemblies in Ex Vivo Multicellular Organisms

    The authors produced metal structures that replicated the specific protein assemblies of neurons in mouse brain or the ECM in mouse kidney and heart.
    [Advanced Materials]

    Abstract

    Multitier Mechanics Control Stromal Adaptations in the Swelling Lymph Node

    Scientists characterized the biomechanics of lymph node swelling on the cellular and organ scale. They identified lymphocyte trapping by influx and proliferation as drivers of an outward pressure force, causing fibroblastic reticular cells of the T-zone and their associated conduits to stretch.
    [Nature Immunology]

    Full Article

    ECM-Mimetic Immunomodulatory Hydrogel for Methicillin-Resistant Staphylococcus aureus–Infected Chronic Skin Wound Healing

    Inspired by the chemical components, fibrous structure, and biological function of natural ECM, an antibacterial and tissue environment–responsive glycopeptide hybrid hydrogel was developed for chronic wound healing.
    [Science Advances]

    Full Article

    Spatially Resolved Proteomic Map Shows That Extracellular Matrix Regulates Epidermal Growth

    A hierarchical skin proteome map was constructed using spatial quantitative proteomics combined with decellularization, laser capture microdissection, and mass spectrometry.
    [Nature Communications]

    Full Article

    Robust Hydrogel Adhesion by Harnessing Bioinspired Interfacial Mineralization

    Investigators reported a strategy for establishing strong interfacial adhesion between various hydrogels and a wide variety of substrates even under wet conditions.
    [Small]

    Abstract

    Simple Synthesis of Soft, Tough, and Cytocompatible Biohybrid Composites

    Researchers demonstrated the development of stiff and tough biohybrid composites by combining collagen with a zwitterionic hydrogel through simple mixing.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full ArticlePress Release

    Regulation of the COPII Secretory Machinery via Focal Adhesions and Extracellular Matrix Signaling

    Using high-throughput microscopy, investigators comprehensively screened 378 cytoskeleton-associated and related proteins for their functional interaction with the coat protein complex II (COPII) components SEC23A and SEC23B.
    [Journal of Cell Biology]

    Full Article

    CD8+ T Cell Responses Are Boosted by Dual PD-1/VEGFR2 Blockade after EGFR Inhibition in Egfr-Mutant Lung Cancer

    PD-1/VEGFR2 dual blockade did not exert tumor-inhibitory effects without pre-treatment with the EGFR-TKI, suggesting that treatment schedule is crucial for efficacy of the dual blockade therapy.
    [Cancer Immunology Research]

    Abstract

    Tissue Engineering Cartilage with Deep Zone Cytoarchitecture by High-Resolution Acoustic Cell Patterning

    The authors showed that ultrasound standing waves could be used to remotely organize living chondrocytes into high-resolution anisotropic arrays, distributed throughout the full volume of agarose hydrogels.
    [Advanced Healthcare Materials]

    Abstract

    Single-Cell Atlas of Keratoconus Corneas Revealed Aberrant Transcriptional Signatures and Implicated Mechanical Stretch as a Trigger for Keratoconus Pathogenesis

    Scientists confirmed the central role of corneal stromal cells in this disease, where dysregulation of collagen and ECM occurred.
    [Cell Discovery]

    Full Article

    Effect of Extracellular Matrix Proteins on the Differentiation of Human Pluripotent Stem Cells into Mesenchymal Stem Cells

    Researchers differentiated human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells into human mesenchymal stem cells (hMSCs) on dishes coated with different ECM proteins to study the effect of cell culture biomaterials on hPSC differentiation into hMSCs.
    [Journal of Materials Chemistry B]

    AbstractGraphical Abstract

    Preparation of Laser Microporous Porcine Acellular Dermal Matrix and Observation of Wound Transplantation

    A novel porcine acellular dermis matrix was prepared by using sequential combined decellularization of trypsin, neutral protease and SDS solution method and fully rinsed with ultrasonic wave.
    [Cell and Tissue Research]

    Full Article

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    REVIEWS

    Co-Dependencies in the Tumor Immune Microenvironment

    Scientists review highlights how specific genetic alterations in cancer cells establish various symbiotic co-dependencies with surrounding host cells and details the cooperative role of the host cells in tumor biology.
    [Oncogene]

    Abstract

    Cellular Senescence in Acute and Chronic Wound Repair

    Transiently present senescence is important for skin repair, where it accelerates ECM formation, limits fibrosis, promotes reepithelialization, and modulates inflammation.
    [Cold Spring Harbor Perspectives in Biology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Stem Cell and Skin Regeneration: Hamilton Health Sciences Creates World-Class Burn Treatment Program

    One of Ontario’s only two burn centers is developing a world-class program to provide specialized treatment in the Hamilton-Niagara region and beyond.
    [In The Hammer]

    Press Release

    FEATURED EVENT

    The Matrix in Development

    September 12 – 14, 2022
    Liverpool, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Secondary DNA Structures in the ECM of Bacterial Biofilms

    Aarhus University – Aarhus, Denmark

    Associate Professor – Thematic Research Programs

    The Chinese University of Hong Kong – Hong Kong, China

    Professor – Experimental Diabetes Research

    Uppsala University – Uppsala, Sweden

    Postdoctoral Fellow – Tumor Microenvironment

    University of California, San Francisco – San Francisco, California, United States

    Scientific Director – Electrophysiology and Heart Modeling

    Electrophysiology and Heart Modeling Institute – Bordeaux, France

    > See All Jobs

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