Extracellular Matrix News Volume 1.01 | Apr 29 2010

Harnessing Traction-Mediated Manipulation of the Cell/Matrix Interface to Control Stem-Cell Fate
The findings suggest that cells interpret changes in the physical properties of adhesion substrates as changes in adhesion-ligand presentation, and that cells themselves can be harnessed as tools to mechanically process materials into structures that feed back to manipulate their fate. [Nat Mater]

Acellular Dermal Matrix and Short Bowel Syndrome
Researchers evaluated the efficacy of acellular dermal matrix (ADM) for intestinal elongation in an animal model. It seemed that ADM was not suited to using alone as a scaffold for the intestinal elongation. [Press release from PhysOrg discussing online prepublication in World Journal of Gastroenterology]

Derive iPSCs feeder-free* with mTeSR®1 by STEMCELL Technologies     *Sun et al., PNAS, 2009

Dendrite Reshaping of Adult Drosophila Sensory Neurons Requires Matrix Metalloproteinase-Mediated Modification of the Basement Membranes
The findings suggest that regulated proteolytic alteration of the extracellular matrix microenvironment might be a fundamental mechanism to drive a large-scale change of dendritic structures during reorganization of neuronal circuits. [Dev Cell]

Significant Type I and Type III Collagen Production from Human Periodontal Ligament Fibroblasts in 3D Peptide Scaffolds without Extra Growth Factors
Researchers report the development of two peptide scaffolds designed for periodontal ligament fibroblasts. The scaffolds consist of one of the pure self-assembling peptide scaffolds RADA16 through direct coupling to short biologically active motifs. [PLoS One]

Direct Activation of Emmprin and Associated Pathogenesis by an Oncogenic Herpesvirus
Investigators used primary human fibroblasts and endothelial cells to determine whether Kaposi’s sarcoma-associated herpesvirus (KSHV) itself regulates extracellular matrix metalloproteinase inducer (emmprin) expression, and whether KSHV-emmprin interactions mediate cell invasiveness. [Cancer Res]

Carcinoma-Associated Fibroblasts Promoted Tumor Spheroid Invasion on a Microfluidic 3D Co-Culture Device
Researchers present a microfluidic-based 3D co-culture device to reconstruct an in vitro tumor microenvironment and firstly investigate the effect of carcinoma-assisted fibroblasts on cancer cell invasion in 3D matrix. [Lab Chip]

The Effect of Scaffold Composition on the Early Structural Characteristics of Chondrocytes and Expression of Adhesion Molecules
Chondrocytes respond to biomaterials early after implantation by altering ultrastructural characteristics and expression of CD44 and integrin beta1. [Biomaterials]

A Comparison of the Influence of Material on In Vitro Cartilage Tissue Engineering with PCL, PGS, and POC 3D Scaffold Architecture Seeded with Chondrocytes
The goal of this study was to determine material effects on cartilage regeneration for scaffolds with the same controlled architecture. The 3D polycaprolactone (PCL), poly (glycerol sebacate) (PGS), and poly (1,8 octanediol-co-citrate) (POC) scaffolds of the same design were physically characterized and tissue regeneration in terms of cell phenotype, cellular proliferation and differentiation, and matrix production were compared to find which material would be most optimal for cartilage regeneration in vitro. [Biomaterials]

Chitosan-Alginate 3D Scaffolds as a Mimic of the Glioma Tumor Microenvironment
Here researchers report on the use of a three-dimensional (3D) chitosan-alginate (CA) scaffold to serve as an extracellular matrix that promotes the conversion of cultured cancer cells to a more malignant in vivo-like phenotype. [Biomaterials]

Extracellular DNA: A Major Proinflammatory Component of Pseudomonas aeruginosa Biofilms
Because extracellular DNA is a key component of biofilms of different bacterial species, the aim of this study was to determine whether it plays a role in the ability of biofilms to induce human neutrophil activation. [J Immunol]

Repair of Traumatic Skeletal Muscle Injury with Bone Marrow-Derived Mesenchymal Stem Cells Seeded on Extracellular Matrix
The data suggest that the repair of a skeletal muscle defect injury by the implantation of a muscle-derived extracellular matrix seeded with mesenchymal stem cells can improve functional recovery after 42 days. [Tissue Eng Part A]

Application of Acellular Dermal Matrix for Intestinal Elongation in Animal Models
Researchers investigated the efficacy of acellular dermal matrix for intestinal elongation in animal models. [World J Gastroenterol]

Cipla Ties Up with Stempeutics for Stem Cell Therapies
Cipla, the largest domestic drug manufacturer, has tied up with the Manipal Group-promoted Stempeutics Research to market stem cell-based therapies. [Business Standard]

Anaspec Introduces MMP Recombinant Proteins
Anaspec has announced the release of three new matrix metalloproteinase (MMP) recombinant proteins: MMP-1, MMP-9 and MMP-12. These proteins, derived from the catalytic domain of the proteins, are supplied as activated proteins. [Laboratory Talk]

Gubernatorial Candidates Talk Ways to Boost Bioscience
Five gubernatorial candidates offered their prescriptions for creating a healthier climate for Minnesota’s biotech industry that included lower taxes, higher government spending, and faith in science over ideology. [Minnesota, United States]

Instructions for Completion and Technical Evaluation of the Vertebrate Animal Section (VAS) in NIH Contract Proposals (NOT-OD-10-049) [National Institutes of Health, United States]

Request for Information (RFI): Priorities for the NIH Adherence Research Network (NOT-OD-10-078) [National Institutes of Health, United States]

Waivers for Conflicts of Interest for the May 7, 2010 Vaccines and Related Biological Products Advisory Committee Meeting [Center for Biologics Evaluation and Research, United States]

FDA Announces Draft Revised Guidance on Transparency and Advisory Committees [Food and Drug Administration, United States]

Risk Communication Advisory Committee; Notice of Meeting [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]

Draft Guidance for the Public, Food and Drug Administration Advisory Committee Members, and Food and Drug Administration Staff: Public Availability of Advisory Committee Members’ Financial Interest Information and Waivers; Availability [Docket No. FDA-2002-D-0094] [Food and Drug Administration, United States]

Society for Biological Engineering’s (SBE) Second International Conference on Stem Cell Engineering 
May 2-5, 2010
Boston, United States

Stem Cells, Tissue Homeostasis and Cancer Conference
May 12-15, 2010
Heidelberg, Germany

Mater Medical Research Institute (MMRI) Stem Cell Symposium 2010: Epigenetics, Transcriptomics and Nanobiotechnology of Stem Cells
May 20-21, 2010
Brisbane, Australia

16th Annual International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States

Systems Biology of Stem Cells
May 24-25, 2010
Irvine, United States

International Scientific Symposium: Stem Cells in Biology and Disease
May 26-28, 2010
Lisbon, Portugal

American Society for Artificial Internal Organs (ASAIO) 56th Annual Conference
May 27-29, 2010
Baltimore, United States

46th American Society of Clinical Oncology (ASCO) Annual Meeting
June 4-8, 2010
Chicago, United States

The First Cedars-Sinai Regenerative Medicine Scientific Symposium
June 14, 2010
Los Angeles, United States

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

21st Meeting of the European Association for Cancer Research (EACR) 
June 26-29, 2010
Oslo, Norway

United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China

The European Molecular Biology Organization (EMBO) Meeting – Advancing the Life Sciences
September 4-7, 2010
Barcelona, Spain

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States 

15th Congress of the European Society of Surgical Oncology (ESSO)
September 15-17, 2010
Bordeaux, France

9th Annual Human Proteome Organization (HUPO) World Congress
September 19-23, 2010
Sydney, Australia

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

Fraunhofer Life Science Symposium 2010
October 29-30, 2010
Leipzig, Germany

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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