Extracellular Matrix News Volume 1.08 | Jun 17 2010

Transient Frictional Slip Between Integrin and the ECM in Focal Adhesions Under Myosin II Tension
Researchers have identified a tension-dependent, extracellular “clutch” between integrins and the extracellular matrix (ECM); this clutch stabilizes adhesions under myosin II driven tension. [Curr Biol]

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Scientists Take First Steps in Growing Working Livers
Scientists have created working liver grafts in the lab, and say the research could one day allow the growth of livers for transplant. [Press release from BBC Science News discussing online prepublication in Nature Medicine]

Human Embryonic-Like Extracellular Matrix Significantly Inhibits Tumor Growth and Cancer Cell Proliferation
Studies of the human extracellular matrix produced under proprietary conditions of hypoxia and suspension have demonstrated its ability to diminish or eliminate tumor load in melanoma, breast cancer, colon cancer and glioma, both in vitro and in vivo. [Press release from Histogen, Inc. discussing research presented at the International Society for Stem Cell Research Annual Meeting]

Organ Reengineering Through Development of a Transplantable Recellularized Liver Graft Using Decellularized Liver Matrix
Results provide a proof of principle for the generation of a transplantable liver graft as a potential treatment for liver disease. [Nat Med]

NHE1 Promotes Invadopodial Extracellular Matrix Proteolysis Through Acidification of the Peri-Invadopodial Space
Utilizing a novel system for in situ zymography in native matrices, researchers show that the Na+/H+ exchanger (NHE1) and NHE1-generated extracellular acidification are localized at and necessary for invadopodial-dependent extracellular matrix degradation, thereby promoting tumor invasion. [FASEB J]

Effect of Media Mixing on Extracellular Matrix Assembly and Mechanical Properties of Anatomically-Shaped Tissue Engineered Meniscus
This study suggests that fluid mixing can be optimized to enhance mechanical properties of anatomically-shaped engineered constructs. [Biomaterials]

Cartilage Repair Using Hyaluronan Hydrogel-Encapsulated Human Embryonic Stem Cell-Derived Chondrogenic Cells
Researchers explored the potential of human embryonic stem cell-derived chondrogenic cells to produce an extracellular matrix-enriched cartilaginous tissue construct when cultured in hyaluronic acid-based hydrogel, and further investigated the long-term reparative ability of the resulting human embryonic stem cell-derived chondrogenic cell-engineered cartilage in an osteochondral defect model. [Biomaterials]

Zinc Induces Structural Reorganization of Gelatin Binding Domain from Human Fibronectin and Affects Collagen Binding
Researchers present the 2.5-angstrom resolution crystal structure of its 45-kDa gelatin-binding domain, which also corresponds to the C-terminal half of the migration stimulating factor, a Fibronectin splice variant expressed in human breast cancers. [Structure]

Adrenal Extracellular Matrix (ECM) Scaffolds Support Adrenocortical Cell Proliferation and Function In Vitro
Researchers conclude that adrenal ECM supports endocrine function and proliferation of adrenocortical cells in vitro. [Tissue Eng Part A]

Xenogeneic Extracellular Matrix as an Inductive Scaffold for Regeneration of a Functioning Musculotendinous Junction
Researchers sought to determine the ability of an extracellular matrix-based scaffold to facilitate functional restoration of the distal gastrocnemius musculotendinous junction in a canine model following complete resection of the tissue. [Tissue Eng Part A]

Fibrin Degradation Enhances Vascular Smooth Muscle Cell Proliferation and Matrix Deposition in Fibrin-Based Tissue Constructs Fabricated In Vitro
Researchers developed techniques to quantify fibrin degradation products and examine plasmin activity in the conditioned medium from fibrin-based constructs. [Tissue Eng Part A]

A Model of Fibroblast Motility on Substrates with Different Rigidities
Researchers developed a discrete model of fibroblast motility with substrate-rigidity sensing which allows researchers to understand the interplay between the cell-substrate sensing and the cell biomechanics. [Biophys J]

Self-Assembly-Peptide Hydrogels as Tissue-Engineering Scaffolds for Three-Dimensional Culture of Chondrocytes In Vitro
The promising potential of a RAD-16 self-assembly-peptide hydrogel as a scaffold for tissue-engineered cartilage was investigated. [Macromol Biosci]

Analysis of Matrix-Dependent Cell Migration with a Barrier Migration Assay
Researchers describe a barrier cell migration assay which is a useful tool for exploring matrix-dependent migration of adherent cells. [Sci Signal]

BioTime Forms New Subsidiary, OrthoCyte Corporation, to Develop Treatments for Orthopedic Conditions Using Stem Cell Technology
BioTime, Inc. announced that it has organized a new subsidiary, OrthoCyte Corporation, for the purpose of developing novel therapeutics based on stem cell technology for the treatment of injuries and disorders affecting the musculoskeletal system, including therapeutics that would regenerate bone, cartilage, tendons and ligaments. [BioTime, Inc. Press Release]

ProFibrix and CSL Behring Enter into Fibrinogen and Thrombin Supply Agreement 
ProFibrix B.V. announced that it has entered into an agreement with CSL Behring for the clinical and commercial supply of plasma-based fibrinogen and thrombin, for the manufacturing of Fibrocaps™. [ProFibrix B.V. Press Release]

U.S. Biotech Firms Line Up for Tax Credits
Starting on 21 June, many small biotech companies will be racing to take advantage of a tax credit worth up to $5 million per company and totaling $1 billion as part of the Therapeutic Discovery Project Program. [NatureNews]

CorMatrix® ECM™ Receives CE Mark for Cardiac Tissue Repair
CorMatrix® Cardiovascular announced it has received CE mark for its CorMatrix Extra Cellular Matrix (ECM) for Cardiac Tissue Repair. [PR Newswire]

NIH Approves Advanced Cell Technology’s Stem Cell Line for Federal Funding
Advanced Cell Technology, Inc. announced that human embryonic stem cell line MA135 was unanimously approved for federal funding at the 100th Meeting of the Advisory Committee to the Director National Institutes of Health (NIH). [Advanced Cell Technology, Inc. Press Release]

Companies Pledge to Make More Trial Data Public
An international organization of pharmaceutical companies has adopted new guidelines governing the publication of clinical trial results. The policy calls for the industry to publish the results of late-stage, ‘phase III’ clinical trials in peer-reviewed journals, regardless of the trials’ outcome. [NatureNews]

The Path to Personalized Medicine
The leaders of the National Institutes of Health and the Food and Drug Administration have a shared vision of personalized medicine and the scientific and regulatory structure needed to support its growth. Together, they have been focusing on the best ways to develop new therapies and optimize prescribing by steering patients to the right drug at the right dose at the right time. [Food and Drug Administration and the National Institutes of Health, United States]

Diseased Cells Fail to Win Approval
In the latest obstacle to expanding the number of embryonic stem-cell lines eligible for U.S. federal funding, a National Institutes of Health committee has unanimously rejected dozens of cell lines carrying mutations for specific diseases. [National Institutes of Health, United States]

New Videos Reveal How NIH Identifies the Most Promising Research Applications
The National Institutes of Health’s Center for Scientific Review released a new video to show new applicants and others how NIH assesses over 80,000 grant applications each year to help find those with the most merit. [National Institutes of Health, United States]

Hospital Clinic de Barcelona Obtained the First Accreditation for Cell Therapy Research
The certification, awarded for the first time in Catalonia, allows the Hospital Clinic de Barcelona to produce drugs in gene therapy, cell therapy and tissue engineering. [Spanish Medicines Agency, Spain]

Enhancing Peer Review: Advance Notice on Post-Submission Application Materials for NIH Training and Related Applications (NOT-OD-10-104) [National Institutes of Health, United States]

PFINDR: Phenotype Finder IN Data Resources: A Tool to Support Cross-study Data Discovery Among NHLBI Genomic Studies (UH2/UH3) (RFA-HL-11-020) [National Institutes of Health, United States]

Roster of the Cellular, Tissue and Gene Therapies Advisory Committee  [Center for Biologics Evaluation and Research, United States]

EVENTS

5th International Conference on Times of Polymers (TOP) & Composites
June 20-23, 2010
Ischia, Italy

4th Annual Seminar — Key Issues for Commercialization in Regenerative Medicine
June 23, 2010
Edinburgh, Scotland

21st Meeting of the European Association for Cancer Research (EACR) 
June 26-29, 2010
Oslo, Norway

UK Society for Biomaterials Annual Conference
July 1-2, 2010
Glasgow, Scotland

United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

Regenerative Medicine Iasi (ReMedIs) 2010
July 15-18, 2010
Iasi, Romania

The Tissue & Cell Engineering Society 2010 Meeting
July 28-30, 2010
Manchester, United Kingdom

2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2)
August 2-4, 2010
Singapore

2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China

The European Molecular Biology Organization (EMBO) Meeting – Advancing the Life Sciences
September 4-7, 2010
Barcelona, Spain

23rd European Conference on Biomaterials
September 11-15, 2010
Tampere, Finland

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States 

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

15th Congress of the European Society of Surgical Oncology (ESSO)
September 15-17, 2010
Bordeaux, France

9th Annual Human Proteome Organization (HUPO) World Congress
September 19-23, 2010
Sydney, Australia

Symposium on Advanced Wound Care
September 23-25, 2010
Anaheim, United States

4th International Conference on Biofabrication
October 4-6, 2010
Philadelphia, United States

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

BioStar 2010 – 4th Congress on Regenerative Biology and Medicine
October 13-15, 2010
Stuttgart, Germany

American Society for Matrix Biology (ASMB) 2010 Biennial Meeting
October 24-27, 2010
Charleston, United States

Select Biosciences 2nd Annual Lab-on-a-Chip World Congress
October 28-29, 2010
San Diego, United States

Fraunhofer Life Science Symposium 2010
October 29-30, 2010
Leipzig, Germany

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

Medica 2010
November 17-20, 2010
Dusseldorf, Germany

Translational Excellence in Regenerative Medicine – Biophysical Stimuli and Mass Transport for Tissue Development
November 18-19, 2010
Lattrop, The Netherlands

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Select Biosciences 5th Annual Stem Cells World Congress
January 24-25, 2011
San Diego, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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