Extracellular Matrix News 10.37 September 26, 2019 | |
| |
TOP STORYMediator Condensates Localize Signaling Factors to Key Cell Identity Genes Scientists present evidence that signaling factors for the WNT, TGF-β, and JAK/STAT pathways used their intrinsically disordered regions to enter and concentrate in Mediator condensates at super-enhancers. [Mol Cell] Abstract | Graphical Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)Fibulin-4 Exerts a Dual Role in LTBP-4L-Mediated Matrix Assembly and Function Researchers demonstrated mechanisms in elastogenesis, focusing on the interaction and functional interdependence between fibulin-4 and latent TGF binding protein (LTBP)-4L and its impact on matrix deposition and function. [Proc Natl Acad Sci USA] Abstract In basal cells, Wnt prevented specification of epithelial cell types by activating ΔN-TP63, a master transcription factor, which was necessary and sufficient to mediate the Wnt-induced inhibition of specification and was required to retain basal cells during development. [Cell Rep] Full Article | Graphical Abstract NLRP3 Inflammasome Blockade Reduces Adipose Tissue Inflammation and Extracellular Matrix Remodeling The expression of different components of the inflammasome as well as their main effectors and inflammation- and ECM remodeling-related genes were analyzed. The impact of blocking NLRP3 using siRNA in lipopolysaccharide-mediated inflammation and ECM remodeling signaling pathways was evaluated. [Cell Mol Immunol] Abstract Smad proteins were detected in the mitochondria of CD4+ T cells, where they were phosphorylated upon treatment with transforming growth factor-β (TGF-β). Phosphorylated Smad proteins were also detected in the mitochondria of isolated tumor-associated lymphocytes. [Sci Signal] Full Article Linc00645 expression was significantly upregulated in glioblastoma tissues and cell lines. Knockdown of linc00645 suppressed the proliferation, stemness, migration, invasion, and reversed transforming growth factor (TGF)-β-induced motility of glioma cell lines. [Cell Death Dis] Full Article Soluble Signals and Remodeling in a Synthetic Gelatin-Based Hematopoietic Stem Cell Niche A library of methacrylamide-functionalized gelatin hydrogels was used to explore remodeling and crosstalk from mesenchymal stromal cells on the expansion and quiescence of murine hematopoietic stem cells. [Adv Healthc Mater] Abstract The deposition of human islet amyloid polypeptide aggravated the compression-induced intervertebral disc degeneration that promoted nucleus pulposus cell apoptosis and ECM degradation via IL-1β/IL-1Ra signaling in an ex vivo rat disc model. [Exp Mol Med] Full Article Investigators analyzed perineuronal nets in a quadruple knockout mouse deficient for the ECM molecules tenascin-C, tenascin-R, neurocan and brevican. While they found an increase in the number of excitatory synaptic molecules in the quadruple knockout cultures, the number of inhibitory synaptic molecules was significantly reduced. [Sci Rep] Full Article Using conditioned media from control and Mitomycin C (MMC) treated cells, researchers demonstrated that factors secreted by MMC-treated corneal epithelial cells attenuated collagen deposition by HCFs whereas those secreted by MMC-treated HCFs did not. [Sci Rep] Full Article Subscribe to one of our other 19 science newsletters such as Endothelial Cell News & Dermal Cell News. | |
| |
REVIEWSTargeting Metabolic Dysregulation for Fibrosis Therapy The authors summarize the evidence to date and describe novel opportunities for the discovery and development of drugs for metabolic reprogramming, their associated challenges, and their utility in reducing fibrosis. [Nat Rev Drug Discov] Abstract Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
| |
INDUSTRY NEWSMallinckrodt plc announced positive top-line results from its pivotal Phase III clinical trial of its investigational StrataGraft® regenerative tissue. The study, which met both primary endpoints, evaluated the efficacy and safety of a single application of StrataGraft in the treatment of deep partial-thickness thermal burns. Each study participant served as his or her own control. [Mallinckrodt plc] Press Release Printerprezz and Osseus Partner to Develop Family of 3D Printed Spine Implants PrinterPrezz, Inc. announced an agreement to work together on new spinal interbody fusion devices with Osseus Fusion Systems. The two companies have been collaborating since late 2018 to develop the next generation Aries series of products, including ALIF, cervical and expandable lumbar fusion cage designs. [PrinterPrezz, Inc.] Press Release | |
| |
POLICY NEWSSituation Improves Slightly for U Alaska, Major Changes Ahead Funding cuts provoke concerns about job losses, canceled research programs, and closed departments. [The Scientist] Editorial How US Sanctions Are Crippling Science in Iran After almost a year of sanctions put in place by US President Donald Trump, Iran is experiencing economic recession, a depreciating currency and high inflation. All of this is stretching budgets for equipment, supplies and travel, endangering research projects and sapping morale, say researchers. [Nature News] Editorial
| |
EVENTSNEW Gordon Ressearch Conference: Linking Cells, the Cytoskeleton and the Nucleus in Mechanobiology, Aging and Disease Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW PhD Student – Receptor-Independent Signaling (University Hospital of Muenster) Scientist – Matrix Biology (STEMCELL Technologies Inc.) Postdoctoral Fellow – Wound Healing (University of Pennsylvania) Postdoctoral Researcher – Proteoglycans in Post-Traumatic Osteoarthritis (Drexel University) Postdoctoral Researchers – Engineering Human Tissues (Columbia University) Postdoctoral Researcher – Molecular Mechanisms of Psychiatric Disorders (McLean Hospital) Postdoctoral Position – Receptor Biology (Scripps Research Institute) Research Scientist – Intestinal Injury/Tissue Engineering (Nationwide Children’s Hospital) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Extracellular Matrix News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|