 | | Vol. 12.25 – 25 June, 2020 |
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| Researchers highlight the key findings from studies of Hippo pathway signaling across biological processes and diseases, and discuss new strategies and therapeutic implications of targeting this pathway.
[Nature Reviews Drug Discovery] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| A decellularized cardiac extracellular matrix‐based nanocomposite hydrogel was developed to provide superior mechanical stability, catheter injectability, retrievability, antibacterial properties, and biological activity to prevent recanalization.
[Advanced Materials] |
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| Direct co-culture with postnatal cardiac fibroblasts increased cardiomyocyte binucleation, which could be inhibited by RGD peptide treatment.
[Circulation Research] |
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| Scientists demonstrated T cells could be re-engineered to express functional argininosuccinate synthase or ornithine transcarbamylase enzymes, in concert with different chimeric antigen receptors.
[Blood] |
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| Investigators tested whether the inflammatory nature of oncolytic viruses and their ability to remodel the tumor microenvironment may help to recruit and potentiate the functionality of CAR T cells.
[Nature Communications] |
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| The authors observed that circadian disruption significantly increased cancer-cell dissemination and lung metastasis. It also enhanced the stemness and tumor-initiating potential of tumor cells and created an immunosuppressive shift in the tumor microenvironment.
[Nature Communications] |
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| Investigators report a tissue-engineering approach to accelerate and standardize the production of retinal organoids by culturing mouse ESCs in optimal physico-chemical microenvironments.
[Scientific Reports] |
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| Researchers identified that Transient Receptor Potential Vanilloid 4 (TRPV4), a mechanosensitive ion channel mediated lung fibroblast differentiation and D. farinae-induced airway remodeling via a novel TRPV4-NADPH Oxidase 4 interaction.
[Scientific Reports] |
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| Inhibition of Erk1/2, tyrosine kinase, and/or GSK-3β was implied to be involved in the enhancement of the PI3K-AKT signaling pathway in the undifferentiated cells, resulting in the sustained stemness, and subsequent conversion of mouse iPSCs into cancer stem cells in the tumor microenvironment.
[Scientific Reports] |
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| The authors explore current strategies that shift immune cell metabolism to pro-inflammatory states in the tumor microenvironment and highlight a need to better replicate physiologic conditions to select targets, clarify mechanisms, and optimize metabolic inhibitors.
[Molecular Cell] |
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| Scientists discuss the potential of anti-neurogenesis and, considering the interplay between nervous and immune systems, they also focus on anti-immunosuppression-based therapies.
[Signal Transduction and Targeted Therapy] |
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| A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers.
[The Scientist] |
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| Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
[ScienceInsider] |
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| 2020-10-12 – 2020-10-14
Paris, France | |
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| | Drexel University – Philadelphia, Pennsylvania, United States |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | The University of Washington – Seattle, Washington, United States |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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| | Genetech, Inc. – San Francisco, California, United States |
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