 | | Vol. 11.45 – 17 November, 2022 |
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| Scientists established a DNA-driven cell culture platform that could be programmed to present the RGD peptide from fibronectin, mimicking cell-ECM interactions, and the HAVDI peptide from N-cadherin, mimicking cell-cell interactions.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that proteinases played an important role in the maintenance of the epithelial barrier. Their results revealed a novel mechanism of tight junction (TJ) maintenance through the localized proteolysis of EpCAM at TJ leaks.
[Journal of Cell Biology] |
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| The authors incorporated calreticulin (CRT) via polyblend electrospinning into polycaprolactone/type 1 collagen nanofibers as biomimetic ECMs to provide a novel mode of delivery and protection of CRT with enhanced synergistic activities for tissue regeneration.
[ACS Applied Materials & interfaces] |
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| Investigators found that radiofrequency ablation reduced pancreatic ductal adenocarcinoma tumor progression in vivo and promoted strong tumor microenvironment remodeling.
[Cancer Immunology Research] |
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| The functionalization of the multilayer with lipoplexes encapsulating DNA encoding for transient expression of bone morphogenetic protein 2 induced osteogenic differentiation of MSCs.
[Advanced Healthcare Materials] |
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| The acemannan and native collagen-scaffold’s biocompatibility, growth factor secretion, osteogenic protein expression, and calcification were evaluated in vitro.
[International Journal of Biological Macromolecules] |
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| Researchers used an innovative approach to recycle the discarded varicose vein for isolation of endothelial cells and decellularization of the same sample to formulate the decellularized ECM bioink.
[International Journal of Biological Macromolecules] |
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| Investigators used dextran conjugated with poly(amidoamine) (Dextran-PAMAM) as a gene carrier to deliver MMP-9 targeted siRNA (siMMP-9). The prepared complexes could be endocytosed with low cytotoxicity to HaCat cells.
[Bioconjugate Chemistry] |
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| A full-thickness skin wound model was established in Sprague Dawley rats to evaluate the therapeutic effects of different poly(lactic-co-glycolic) acid (PLGA) knitted mesh-collagen-chitosan scaffold against collagen-based scaffold.
[Journal of Biomedical Materials Research Part B-Applied Biomaterials] |
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| Scientists summarize the establishment and regulation of ECM stiffness, the mechanisms underlying how ECM stiffness is sensed by cells, and signals to modulate diverse cell metabolic pathway.
[Reviews in Endocrine and Metabolic Disorders] |
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| A University at Buffalo researcher has been awarded a National Heart, Lung and Blood Institute grant to explore how changes in arterial stiffness elicit vascular smooth muscle cell behaviors that contribute to cardiovascular disease.
[University at Buffalo] |
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| January 23 – 25, 2023
Breckenridge, Colorado, United States |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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| | Biosynth – Lelystad, Netherlands |
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| | Cancer Research UK Manchester Institute – Manchester, England, United Kingdom |
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| | King’s College London – London, England, United Kingdom |
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| | Sanofi – Amsterdam, Netherlands |
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Cancer Stem Cell News
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