 | | Vol. 12.07 – 25 February, 2021 |
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| Muscle extracellular matrix (MEM) and induced skeletal myogenic progenitor cells (iMPCs) were integrated within thermally drawn fiber based microchannel scaffolds. The microchannel fibers decorated with MEM enhanced differentiation and maturation of iMPCs.
[Advanced Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that KPT-330 prevented, attenuated and mitigated calcific nodule formation in heart valve interstitial cells in vitro, and prevented calcific aortic valve disease in Klotho-/- mice.
[Circulation Research] |
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| Analysis of TCGA patient datasets showed matrisome signature was enriched in lobular carcinomas with overexpression of elastin, collagens, and the collagen modifying enzyme LOXL1.
[EMBO Molecular Medicine] |
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| The authors report the crosstalk between cancer cells and stromal fibroblasts that leads to tumor progression. The process was initiated by secretion of a chemokine like protein, osteopontin from the cancer cells that differentiated the fibroblasts to myofibroblasts.
[Oncogene] |
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| Biological functions of Elavl1 during osteogenic differentiation of bone marrow derived MSCs (BMSCs) is not well-understood. The authors report that specific knockdown of nuclear localized Elavl1 by RNA interference in multipotent BMSCs led to increased osteogenic differentiation.
[Frontiers in Cell and Developmental Biology] |
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| By exploiting sideness (serous or fibrous surface) of antigen removed-bovine pericardium scaffolds, researchers aimed to determine the mechanism by which ECM niche influences human mesenchymal stem cell migration.
[Scientific Reports] |
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| The authors showed that the mesenchymal stem cells (MSCs) nomadically migrating on a microelastically-patterned matrix with stiffness-heterogeneity markedly amplified intracellular stress dynamics fluctuations and clearly activated a wide variety of gene expressions relating to vigorousness of the cell.
[Biophysical Journal] |
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| Researchers investigated the initiation of fibronectin (FN) matrix assembly using fibroblasts that assembled parallel extracellular matrix fibrils and found that matrix assembly sites, where FN fibrillogenesis is initiated, were oriented in parallel at the cell poles.
[Molecular Biology of the Cell] |
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| Decellularized porcine pericardium scaffolds were modified by growing a fibrin mesh on the surface and inside the scaffolds, and by attaching heparin and human vascular endothelial growth factor to this mesh. Then the scaffolds were seeded with human adipose tissue-derived stem cells.
[Biomedical Materials] |
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| Scientists summarize recent studies investigating the involvement of tumor-associated macrophages in immune checkpoint inhibition, tumor vaccines and adoptive cell transfer therapies.
[Signal Transduction and Targeted Therapy] |
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| Targeting the tumor immune microenvironment, alone or in combination with immune checkpoint-targeting drugs, might benefit cancer patients in the future.
[Signal Transduction and Targeted Therapy] |
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| This guide on the composition and functions of the ECM gives a broad overview of the matrisome, the major ECM macromolecules and their interaction networks within the ECM and with the cell surface, summarizes their main structural features and their roles in tissue organization and cell functions, and emphasizes the importance of specific ECM constituents in disease development and progression as well as the advances in molecular targeting of ECM to design new therapeutic strategies.
[FEBS Journal] |
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| Jubilant Therapeutics Inc. announced a collaboration with Boston Children’s Hospital to evaluate peptidyl arginine deiminase 4 (PAD4) inhibitors under development by Jubilant Therapeutics to explore the modulation of neutrophil extracellular traps in preclinical models of neutrophil regulation and rheumatoid arthritis.
[Jubilant Therapeutics Inc. (PR Newswire Association LLC.)] |
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| October 27 – 29, 2021
Tokyo, Japan |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | The Francis Crick Institute – London, England, United Kingdom |
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| | University of Southern Denmark – Odense M, Denmark |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Merck Sharp and Dohme Limited – London, England, United Kingdom |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
