Extracellular Matrix News Volume 12.11 | Mar 25 2021

May 12, 2022

2021-25-03 | ECM 12.11

Extracellular Matrix News by STEMCELL Technologies

Vol. 12.11 – 25 March, 2021

TOP STORY

Membrane Type 1 Matrix Metalloproteinase Promotes LDL Receptor Shedding and Accelerates the Development of Atherosclerosis

Investigators report that membrane type 1-matrix metalloproteinase co-immunoprecipitated and co-localized with low-density lipoprotein receptor (LDLR) and promoted LDLR cleavage.
[Nature Communications]

Full Article

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PUBLICATIONSRanked by the impact factor of the journal

EPB41L5 Controls Podocyte Extracellular Matrix Assembly by Adhesome-Dependent Force Transmission

Scientists showed by analysis of in vitro and in vivo models that a loss of the podocyte-specific FERM-domain protein EPB41L5 results in impaired ECM assembly.
[Cell Reports]

Full Article Graphical Abstract

Laminin β₂ Variants Associated with Isolated Nephropathy that Impact Matrix Regulation

Researchers report the clinical features of mild isolated nephropathy associated with 3 LAMB2 variants in the LEa-LF-LEb domains and their biochemical characterization.
[JCI Insight]

Full Article Graphical Abstract

Cooperation between Oncogenic Ras and Wild-Type p53 Stimulates STAT Non-Cell Autonomously to Promote Tumor Radioresistance

Investigators discovered that cellular response to genotoxic stress cooperated with oncogenic Ras to activate JAK/STAT non-cell autonomously in the tumor microenvironment.
[Communications Biology]

Full Article

Identification of Extracellular Matrix Proteins Secreted by Human Dermal Fibroblasts Cultured in 3D Electrospun Scaffolds

Researchers constructed an artificial 3D tumor by culturing human breast cancer JIMT-1 cells and human dermal fibroblasts in a 3D network of electrospun polycaprolactone fibers. They investigated ECM components produced by the cells in the artificial 3D tumor, which is an important step in validating the model.
[Scientific Reports]

Full Article

Elastin-Specific MRI of Extracellular Matrix-Remodeling following Hepatic Radiofrequency-Ablation in a VX2 Liver Tumor Model

To investigate the potential of an elastin-specific MR agent for the assessment of ECM remodeling in the periablational rim following radiofrequency ablation in a VX2 rabbit liver tumor-model, 12 New-Zealand-White-rabbits were implanted in the left liver lobe with VX2 tumor chunks from donor animals.
[Scientific Reports]

Full Article

Optimization of Extracellular Matrix Production from Human Induced Pluripotent Stem Cell‐Derived Fibroblasts for Scaffold Fabrication for Application in Wound Healing

Researchers optimized fibroblasts derived from iPS cell matrix production by boosting matrix deposition, without affecting its composition.
[Journal of Biomedical Materials Research Part A]

Full Article

The Extracellular Matrix Complexity of Idiopathic Epiretinal Membranes and the Bilaminar Arrangement of the Associated Internal Limiting Membrane in the Posterior Retina

The authors studied the composition of the internal limiting membrane of the retina, the ECM of idiopathic epiretinal membranes, and the relationships occurring between the two membranes.
[Graefe’s Archive for Clinical and Experimental Ophthalmology]

Full Article

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REVIEWS

Applications of Marine Collagen in Bone Tissue Engineering

Scientists provide an overview of the biological effects of marine collagen in bone engineering, such as promoting osteogenesis and collagen synthesis, inhibiting inflammation, inducing the differentiation of cartilage, and improving bone mineral density.
[Biomedical Materials]

Abstract

INDUSTRY AND POLICY NEWS

Histogen Announces Removal of Clinical Hold by FDA for HST-003 IND to Initiate a Phase I/II Trial for Knee Cartilage Regeneration

Histogen Inc. announced that the FDA has confirmed that the company satisfactorily addressed all clinical hold questions and can proceed with initiation of the planned Phase I/II clinical trial of HST-003 to evaluate the safety and efficacy of human ECM implanted within microfracture interstices and the cartilage defect in the knee to regenerate hyaline cartilage in combination with a microfracture procedure.
[Histogen Inc.]

Press Release

FEATURED EVENT

Membrane Type 1 Matrix Metalloproteinase Promotes LDL Receptor Shedding and Accelerates the Development of Atherosclerosis

EPB41L5 Controls Podocyte Extracellular Matrix Assembly by Adhesome-Dependent Force Transmission

Laminin β₂ Variants Associated with Isolated Nephropathy that Impact Matrix Regulation

Cooperation between Oncogenic Ras and Wild-Type p53 Stimulates STAT Non-Cell Autonomously to Promote Tumor Radioresistance

Identification of Extracellular Matrix Proteins Secreted by Human Dermal Fibroblasts Cultured in 3D Electrospun Scaffolds

Elastin-Specific MRI of Extracellular Matrix-Remodeling following Hepatic Radiofrequency-Ablation in a VX2 Liver Tumor Model

Optimization of Extracellular Matrix Production from Human Induced Pluripotent Stem Cell‐Derived Fibroblasts for Scaffold Fabrication for Application in Wound Healing

The Extracellular Matrix Complexity of Idiopathic Epiretinal Membranes and the Bilaminar Arrangement of the Associated Internal Limiting Membrane in the Posterior Retina

Applications of Marine Collagen in Bone Tissue Engineering

Histogen Announces Removal of Clinical Hold by FDA for HST-003 IND to Initiate a Phase I/II Trial for Knee Cartilage Regeneration

6^th World Congress of the Tissue Engineering and Regenerative Medicine International Society

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