 | | Vol. 12.12 – 1 April, 2021 |
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| Researchers investigated the role of CD148 in the profibrotic phenotype of fibroblasts in idiopathic pulmonary fibrosis. Conditional CD148 fibroblast-specific knockout mice were generated and exposed to bleomycin, and then assessed for pulmonary fibrosis.
[American Journal of Respiratory and Critical Care Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists describe a protocol to generate cardiomyocytes, cardiac fibroblasts and cardiac endothelial cells, the three principal cell types in the heart, from human induced pluripotent stem cells and combine them in 3D cardiac microtissues.
[Nature Protocols] |
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| A novel biofunctional live tissue-engineered bone-like graft was designed and constructed using a fibrin scaffold loaded with TG2 gene-modified ectomesenchymal stem cells (TG2-EMSCs) derived from nasal respiratory mucosa for bone defect repair.
[NPG Asia Materials] |
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| Researchers performed genome‐wide expression analysis comparing fibroblasts in normal, inflammatory and tumor‐associated skin. Cancer‐associated fibroblasts exhibit a fibrotic gene signature in wound‐induced tumors, demonstrating persistent extracellular matrix remodeling within these tumors.
[EMBO Reports] |
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| Scientists developed an approach to extract the cerebrovascular extracellular matrix from mouse and human post-mortem normal brain tissues.
[Journal of Cerebral Blood Flow and Metabolism] |
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| Pathway analysis of the predicted SNED1 interactome revealed that it may contribute to signaling through cell surface receptors, such as integrins, and participate in the regulation of ECM organization and developmental processes.
[Biochemical Journal] |
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| The authors showed that extracellular-signal regulated kinase (ERK) 1/2 were highly phosphorylated in mechanically unloaded tendon fascicles in a vascular niche-dependent manner.
[Scientific Reports] |
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| Researchers report the use of a nanofibrous hydrogel as a 3D scaffold for the culture and maintenance of functional primary human hepatocytes.
[Scientific Reports] |
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| The authors embedded MCF10A normal human breast epithelial cells in two different matrices – collagen type I, and collagen type I+10% Matrigel; treatment with calcitriol resulted in flatter epithelial structures.
[Tissue Engineering Part A] |
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| Scientists hypothesized that stiffening of the airway extracellular matrix is a core pathological change sufficient to support excessive bronchoconstriction even in the absence of inflammation.
[Journal of Applied Physiology] |
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| The authors critically discuss advancements and shortfalls of scaffold-free cell-based tissue engineering strategies, along with pioneering concepts that have the potential to transform regenerative and reparative medicine.
[NPJ Regenerative Medicine] |
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| Foresee Pharmaceuticals Co., Ltd. announced the initiation of patient dosing in the Phase II/III clinical trial of FP-025, its highly selective oral MMP-12 inhibitor, in adult patients with severe to critical COVID-19 with associated Acute Respiratory Distress Syndrome.
[Foresee Pharmaceuticals Co., Ltd.] |
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| January 12 – 14, 2022
Shanghai, China |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Maastricht University – Maastricht, Netherlands |
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| | Florida Atlantic University – Jupiter, Florida, United States |
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| | Tulane School of Medicine – New Orleans, Louisiana, United States |
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| | University of Maryland School of Medicine – Baltimore, Maryland, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
