Extracellular Matrix News Volume 12.16 | Apr 29 2021

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    2021-29-04 | ECM 12.16


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 12.16 – 29 April, 2021
    TOP STORY

    Tumor Restriction by Type I Collagen Opposes Tumor-Promoting Effects of Cancer-Associated Fibroblasts

    The authors sought to understand potentially opposing functions by interrogating functional relationships between cancer-associated fibroblast subtypes, their mediators, desmoplasia and tumor growth in a wide range of tumor types metastasizing to the liver, the most common organ site for metastasis.
    [Journal of Clinical Investigation]

    AbstractFull ArticleGraphical Abstract


    In this webinar on hepatic organoids review the biological characteristics and practical considerations of adding organoids to your research.
    PUBLICATIONSRanked by the impact factor of the journal

    LIMD1 Phase Separation Contributes to Cellular Mechanics and Durotaxis by Regulating Focal Adhesion Dynamics in Response to Force

    Scientists discovered that LIMD1 regulated cell spreading, maintained focal adhesion (FA) dynamics and cellular contractility, and was critical for durotaxis—the ability of cells to crawl along gradients of substrate stiffness.
    [Developmental Cell]

    Full ArticleGraphical Abstract

    Endothelial Cell Invasion Is Controlled by Dactylopodia

    Researchers showed that endothelial tip cells use dactylopodia as the main cellular protrusion for invasion into nonvascular ECM. They showed that dactylopodia and filopodia protrusions were balanced by myosin IIA and actin-related protein 2/3 activity.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Recursive Feedback between Matrix Dissipation and Chemo-Mechanical Signaling Drives Oscillatory Growth of Cancer Cell Invadopodia

    Investigators developed a chemo-mechanical model for dynamics of invadopodia, the protrusive structures that cancer cells use to facilitate invasion, by considering myosin recruitment, actin polymerization, matrix deformation, and mechano-sensitive signaling pathways.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Bioactive Decellularized Extracellular Matrix Derived from 3D Stem Cell Spheroids under Macromolecular Crowding Serves as a Scaffold for Tissue Engineering

    3D decellularized ECM scaffolds derived from mesenchymal stem cell spheroids and with intricate matrix composition were developed.
    [Advanced Healthcare Materials]

    Abstract

    Affinity-Bound Growth Factor within Sulfated Interpenetrate Network Bioinks for Bioprinting Cartilaginous Tissues

    Alginate sulfate, a sulfated glycosaminoglycan mimic, was used to functionalize an alginate-gelatin methacryloyl interpenetrating network bioink to enable the bioprinting of cartilaginous tissues.
    [Acta Biomaterialia]

    Full Article

    Uniaxially Fixed Mechanical Boundary Condition Elicits Cellular Alignment in Collagen Matrix with Induction of Osteogenesis

    Scientists developed a novel in vitro collagen matrix system exerting a uniaxially-fixed mechanical boundary condition on which mouse osteoblast-like MC3T3-E1 cells were subcultured, evoking cellular alignment along the uniaxial boundary condition.
    [Scientific Reports]

    Full Article

    Geometrically Defined Environments Direct Cell Division Rate and Subcellular YAP Localization in Single Mouse Embryonic Stem Cells

    Investigators produced well-defined 2D and 2.5D microenvironments and monitored cell division rate and subcellular yes-associated protein localization in single mouse embryonic stem cells hence excluding cell–cell interactions.
    [Scientific Reports]

    Full Article

    Win, Lose, or Tie: Mathematical Modeling of Ligand Competition at the Cell–Extracellular Matrix Interface

    Toward the goal of fully functional organoid development, the authors hypothesized that resolving the dynamics of ECM–integrin interactions would be highly instructive. To this end, they developed a mathematical model that enabled then to simulate three main interactions, namely integrin activation, ligand binding, and integrin clustering.
    [Frontiers in Bioengineering and Biotechnology]

    Full Article

    Scientists Helping Scientists, Globally - Learn More
    REVIEWS

    Extracellular Matrix and Its Therapeutic Potential for Cancer Treatment

    Researchers summarize the knowledge concerning the following: major ECM constituents and their functions in both normal and malignant conditions; the interplay between cancer cells and the ECM in the tumor microenvironment; key receptors for mechanotransduction and their alteration during carcinogenesis; and the current therapeutic strategies targeting aberrant ECM for cancer treatment.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Hydrogels as Emerging Materials for Cornea Wound Healing

    Scientists critically review in vitro, preclinical, as well as clinical trial studies related to corneal wound healing using hydrogels in the past ten years, as this is considered as an emerging technology for corneal treatment.
    [Small]

    Abstract

    Emerging Technologies Provide Insights on Cancer Extracellular Matrix Biology and Therapeutics

    The authors offer the cell biology and cancer cell biology communities insight into how engineering tools can improve the understanding of cancer ECM biology and therapeutic development.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    INDUSTRY AND POLICY NEWS

    DiscGenics Completes Patient Enrollment in Japanese Clinical Study of Cell Therapy for Disc Degeneration as US Study Achieves One-Year Follow-Up Milestone

    DiscGenics, Inc. announced that it has completed enrollment in its Japanese safety study of IDCT, an allogeneic, injectable Discogenic Cell therapy for lumbar disc degeneration, a major cause of chronic low back pain.
    [DiscGenics, Inc.]

    Press Release

    FEATURED EVENT

    3D Cell Culture

    December 2, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Assistant, Associate, Full Professor – Stem Cell Biology and Regenerative/Restorative Medicine

    Stanford University – Stanford, California, United States

    Scientist/Engineer – Matrix Biology

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Postdoctoral/Research Fellow Position – 3D-Printing & Scaffold Design for Drug/Gene Delivery in Tissue Engineering

    Nanyang Technological University – Singapore, Singapore

    Postdoctoral/Research Fellow Position – In Vivo Scaffold Implantation Studies for ​Tissue Engineering Research

    Nanyang Technological University – Singapore, Singapore

    Research Associate – Cell and Tissue Mechanobiology

    King’s College London – London, England, United Kingdom

    > See All Jobs

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