Extracellular Matrix News Volume 12.20 | May 27 2021

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    2021-05-27 | ECM 12.20


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 12.20 – 27 May, 2021
    TOP STORY

    Single-Cell Protein Activity Analysis Identifies Recurrence-Associated Renal Tumor Macrophages

    Scientists performed single-cell RNA sequencing of hematopoietic and non-hematopoietic subpopulations from tumor and tumor-adjacent tissue of treatment-naive clear cell renal carcinoma resections.
    [Cell]

    AbstractGraphical Abstract

    Explore scientific events this June with the Science Events Calendar.
    PUBLICATIONSRanked by the impact factor of the journal

    Nanoengineered Peptide-Based Antimicrobial Conductive Supramolecular Biomaterial for Cardiac Tissue Engineering

    A di-Fmoc-based hydrogelator containing the cell-adhesive Arg–Gly–Asp fragment that formed a mechanically stable, self-healing hydrogel was designed.
    [Advanced Materials]

    Abstract

    Conserved Pan-Cancer Microenvironment Subtypes Predict Response to Immunotherapy

    The tumor microenvironment subtypes acted as a generalized immunotherapy biomarker across many cancer types due to the inclusion of malignant and microenvironment components.
    [Cancer Cell]

    AbstractGraphical Abstract

    Dissecting the Microenvironment Around Biosynthetic Scaffolds in Murine Skin Wound Healing

    The microenvironment around scaffolds involved an intricate interplay of immune and cutaneous cells.
    [Science Advances]

    Full Article

    Molecular Motion and Tridimensional Nanoscale Localization of Kindlin Control Integrin Activation in Focal Adhesions

    Using single protein tracking, super-resolution microscopy, and functional assays, investigators linked the molecular behavior and 3D nanoscale localization of kindlin with its function in integrin activation inside focal adhesions.
    [Nature Communications]

    Full Article

    Sex-Based Dimorphism of Anticancer Immune Response and Molecular Mechanisms of Immune Evasion

    Researchers investigated sex-based differences in the molecular mechanisms of anticancer immune response and immune evasion in patients with non-small cell lung cancer.
    [Clinical Cancer Research]

    Abstract

    Contractility, Focal Adhesion Orientation, and Stress Fiber Orientation Drive Cancer Cell Polarity and Migration Along Wavy ECM Substrates

    Investigators designed nanotopographic ECM-coated substrates that mimicked collagen fibril waveforms seen in tumors and healthy tissues to determine how these nanotopographies might regulate cancer cell polarization and migration machineries.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    DLL1 Orchestrates CD8+ T Cells to Induce Long-term Vascular Normalization and Tumor Regression

    Scientists showed that elevated levels of Delta-like 1 (DLL1) in the breast and lung tumor microenvironment induced long-term tumor vascular normalization to alleviate tumor hypoxia and promoted the accumulation of interferon γ–expressing CD8+ T cells and the polarization of M1-like macrophages.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Circular RNA ITCH Promotes Extracellular Matrix Degradation via Activating Wnt/β-Catenin Signaling in Intervertebral Disc Degeneration

    The authors explored the effect of circITCH on the ECM degradation of intervertebral disc degeneration and the underlying mechanism.
    [Aging]

    Full Article

    Reticulocalbin 3 Is Involved in Postnatal Tendon Development by Regulating Collagen Fibrillogenesis and Cellular Maturation

    Scientists examined the function of Reticulocalbin 3 in collagen fibrillogenesis and tenocyte maturation during postnatal tendon development using a genetic mouse model.
    [Scientific Reports]

    Full Article

    Transthyretin Amyloid Fibrils Alter Primary Fibroblast Structure, Function and Inflammatory Gene Expression

    Investigators suggested that transthyretin deposited in tissue ECM might affect both the structure, function, and gene expression of cardiac fibroblasts.
    [American Journal of Physiology-Heart and Circulatory Physiology]

    Abstract

    Survey results on the insights and hurdles of CRISPR genome editing.
    REVIEWS

    Cellular Functions of Actin- and Microtubule-Associated Septins

    The authors review septin interactions with actin and microtubules, and septin-mediated regulation of the organization and dynamics of these cytoskeletal networks, which is critical for cellular morphogenesis.
    [Current Biology]

    Full Article

    Actin-Based Force Generation and Cell Adhesion in Tissue Morphogenesis

    Scientists review how mechanisms of actin-based force generation are deployed during animal morphogenesis to sculpt organs and organisms.
    [Current Biology]

    AbstractFull Article

    Organoid Models of the Tumor Microenvironment and Their Applications

    Investigators discuss various organoid culture strategies for modeling the tumor immune microenvironment, their applications, and advantages in cancer research.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    INDUSTRY AND POLICY NEWS

    TELA Bio Initiates BRAVO II Study of OviTex® for the Robotic Repair of Ventral Hernias

    TELA Bio, Inc. launched the company’s second post-market study, BRAVO II, to evaluate the clinical performance of OviTex® Reinforced Tissue Matrices in the robotic repair of ventral hernias. The first patient was enrolled at St. Lukes’s Hospital in Overland Park, Kansas.
    [TELA Bio, Inc.]

    Press Release

    FEATURED EVENT

    Metabolism in Health and Disease

    June 28 – 30, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Associate, Biomedical Sciences

    Frederick National Laboratory – Frederick, Maryland, United States

    Research Fellow Positions – Extracellular Matrix Signaling in Kidney

    Massachusetts General Hospital – Boston, Massachusetts, United States

    Postdoctoral Fellow – Lung Cancer Development and Progression

    University of Virginia – Charlottesville, Virginia, United States

    Postdoctoral Fellowship – Perineuronal Nets and Touchscreen-Based Assessment

    University of Western Ontario – London, Ontario, United States

    Postdoctoral Research Associate – Cardiac Remodeling

    University of Nebraska Medical Center – Omaha, Nebraska. United States

    > See All Jobs

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