Extracellular Matrix News Volume 12.21 | Jun 3 2021

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    2021-06-03 | ECM 12.21


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 12.21 – 3 June, 2021
    TOP STORY

    Injectable Self-Healing Hydrogel via Biological Environment-Adaptive Supramolecular Assembly for Gastric Perforation Healing

    Scientists reported an example of injectable self-healing hydrogel based on gastric environment-adaptive supramolecular assembly and explored its application for gastric perforation healing.
    [ACS Nano]

    AbstractGraphical Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Actuation Enhances Patterning in Human Neural Tube Organoids

    The authors showed that active mechanical forces increased growth and led to enhanced patterning in an organoid model of the neural tube derived from single human pluripotent stem cells.
    [Nature Communications]

    Full Article

    Mechanically Activated Ion Channel Piezo1 Modulates Macrophage Polarization and Stiffness Sensing

    Researchers examined the role of the mechanically activated cation channel Piezo1 in macrophage polarization and sensing of microenvironmental stiffness.
    [Nature Communications]

    Full Article

    WNT5A Inhibition Alters the Malignant Peripheral Nerve Sheath Tumor Microenvironment and Enhances Tumor Growth

    ShWNT5A-treated malignant peripheral nerve sheath tumor cells upregulated mRNAs associated with the remodeling of ECM and with immune cell communication.
    [Oncogene]

    Abstract

    MMP8 Increases Tongue Carcinoma Cell–Cell Adhesion and Diminishes Migration via Cleavage of Anti-Adhesive FXYD5

    FXYD5 is a novel substrate of matrix metalloproteinase 8 (MMP8) and its cleavage from the cell membrane by MMP8 represented a mechanism on how MMP8 increased cell-cell adhesion leading to restrained migration.
    [Oncogenesis]

    Full Article

    Cell Adhesion Factors in the Orbitofrontal Cortex Control Cue-Induced Reinstatement of Cocaine Seeking and Amygdala-Dependent Goal Seeking

    Investigators locally ablated neuronal β1-integrins, cell adhesion receptors that adhere cells to the ECM and thus support dendritic spine stability.
    [Journal of Neuroscience]

    Abstract

    Small Leucine Zipper Protein Promotes the Metastasis of Castration-Resistant Prostate Cancer through Transcriptional Regulation of Matrix Metalloproteinase-13

    The authors investigated the role of small leucine zipper protein in matrix metalloproteinase-13 expression and its involvement in castration-resistant prostate cancer metastasis.
    [Carcinogenesis]

    AbstractGraphical Abstract

    A Human Multi-Cellular Model Shows How Platelets Drive Production of Diseased Extracellular Matrix and Tissue Invasion

    Prompted by findings in patient biopsies, scientists used the model to investigate the role of platelets in malignant cell invasion and ECM production.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Engineering Aligned Human Cardiac Muscle Using Developmentally Inspired Fibronectin Micropatterns

    Researchers identified cell-cell and cell-ECM interactions in the microenvironment of the early four-chambered vertebrate heart that drove cardiomyocyte organization and alignment.
    [Scientific Reports]

    Full Article

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    REVIEWS

    Nanomedicine-Based Strategies to Target and Modulate the Tumor Microenvironment

    The authors discuss the latest nanotechnology-based strategies for cancer diagnosis and therapy as well as the potential targets for the design of future anticancer nanomedicines.
    [Trends in Cancer]

    Abstract

    Molecular and Clinical Insights of Matrix Metalloproteinases Into Cancer Spread and Potential Therapeutic Interventions

    Investigators focus on the tumorigenic functions of matrix metalloproteinases (MMPs) and recent advancements in the development of MMP inhibitors of therapeutic potential in cancer treatment.
    [Toxicology and Applied Pharmacology]

    Abstract

    INDUSTRY AND POLICY NEWS

    UK Research Could Lead to Treatment for Aortic Aneurysms

    A University of Kentucky College of Medicine team will study the culprit behind thoracic aortic aneurysms, which could lead to a treatment for the potentially deadly disease. The key may be in a material called ECM, which binds aortic tissue together.
    [University of Kentucky]

    Press Release

    Histogen Provides Update on Its Development Programs and Pipeline Focus

    Histogen, Inc. announced an update on its pipeline focus following a strategic evaluation of its regenerative medicine platform technology development programs with the goal of focusing on high-value orthopedic indications, creating pipeline synergies, and maximizing resources.
    [Histogen, Inc.]

    Press Release

    FEATURED EVENT

    Society for Developmental Biology 80th Annual Meeting

    July 12 – 16, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Biomechanics Engineer – ECM

    University of Colorado Boulder – Boulder, Colorado, United States

    Postdoctoral Fellow – Bone Metastatic Prostate Cancer

    H. Lee Moffitt Cancer Center – Tampa, Florida, United States

    Research Associate, Biomedical Sciences

    Frederick National Laboratory – Frederick, Maryland, United States

    Research Fellow Positions – Extracellular Matrix Signaling in Kidney

    Massachusetts General Hospital – Boston, Massachusetts, United States

    Postdoctoral Fellow – Lung Cancer Development and Progression

    University of Virginia – Charlottesville, Virginia, United States

    > See All Jobs

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