| Vol. 12.21 – 3 June, 2021 |
| |
|
|
| Scientists reported an example of injectable self-healing hydrogel based on gastric environment-adaptive supramolecular assembly and explored its application for gastric perforation healing. [ACS Nano] |
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| The authors showed that active mechanical forces increased growth and led to enhanced patterning in an organoid model of the neural tube derived from single human pluripotent stem cells. [Nature Communications] |
|
|
|
| Researchers examined the role of the mechanically activated cation channel Piezo1 in macrophage polarization and sensing of microenvironmental stiffness. [Nature Communications] |
|
|
|
| ShWNT5A-treated malignant peripheral nerve sheath tumor cells upregulated mRNAs associated with the remodeling of ECM and with immune cell communication. [Oncogene] |
|
|
|
| FXYD5 is a novel substrate of matrix metalloproteinase 8 (MMP8) and its cleavage from the cell membrane by MMP8 represented a mechanism on how MMP8 increased cell-cell adhesion leading to restrained migration. [Oncogenesis] |
|
|
|
| Investigators locally ablated neuronal β1-integrins, cell adhesion receptors that adhere cells to the ECM and thus support dendritic spine stability. [Journal of Neuroscience] |
|
|
|
| The authors investigated the role of small leucine zipper protein in matrix metalloproteinase-13 expression and its involvement in castration-resistant prostate cancer metastasis. [Carcinogenesis] |
|
|
|
| Prompted by findings in patient biopsies, scientists used the model to investigate the role of platelets in malignant cell invasion and ECM production. [iScience] |
|
|
|
| Researchers identified cell-cell and cell-ECM interactions in the microenvironment of the early four-chambered vertebrate heart that drove cardiomyocyte organization and alignment. [Scientific Reports] |
|
|
|
|
| The authors discuss the latest nanotechnology-based strategies for cancer diagnosis and therapy as well as the potential targets for the design of future anticancer nanomedicines. [Trends in Cancer] |
|
|
|
| Investigators focus on the tumorigenic functions of matrix metalloproteinases (MMPs) and recent advancements in the development of MMP inhibitors of therapeutic potential in cancer treatment. [Toxicology and Applied Pharmacology] |
|
|
|
|
| A University of Kentucky College of Medicine team will study the culprit behind thoracic aortic aneurysms, which could lead to a treatment for the potentially deadly disease. The key may be in a material called ECM, which binds aortic tissue together. [University of Kentucky] |
|
|
|
| Histogen, Inc. announced an update on its pipeline focus following a strategic evaluation of its regenerative medicine platform technology development programs with the goal of focusing on high-value orthopedic indications, creating pipeline synergies, and maximizing resources. [Histogen, Inc.] |
|
|
|
|
| July 12 – 16, 2021 Virtual |
|
|
|
|
|
| University of Colorado Boulder – Boulder, Colorado, United States |
|
|
|
| H. Lee Moffitt Cancer Center – Tampa, Florida, United States |
|
|
|
| Frederick National Laboratory – Frederick, Maryland, United States |
|
|
|
| Massachusetts General Hospital – Boston, Massachusetts, United States |
|
|
|
| University of Virginia – Charlottesville, Virginia, United States |
|
|
|
|