 | | Vol. 12.26 – 15 July, 2021 |
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| Investigators showed that acidosis-mediated tumor insertion enhanced on-target release of matrix metalloproteinase-responsive reporters in urine.
[Nature Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors provided evidence that extracellular translationally controlled tumor protein (TCTP) mediated recruitment of the polymorphonuclear myeloid-derived suppressor cells population in the tumor microenvironment via activation of Toll-like receptor-2.
[Nature Immunology] |
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| Scientists investigated how chemotaxing neutrophils probed matrices and adjusted their migration to collagen concentration changes by tracking 20,000 cell trajectories and quantifying cell-generated 3D matrix deformations.
[Science Advances] |
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| Researchers presented a probe for the simultaneous monitoring and targeting of lysyl oxidases (LOX)-mediated collagen cross-linking that combined a LOX-activity sensor with a collagen peptide to chemoselectively target endogenous aldehydes generated by LOX.
[Nature Chemical Biology] |
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| Investigators reported that the secretory extracellular matrix protein-1 isoform induced tumorigenesis through the GPR motif binding to integrin αXβ2 and the activation of AKT/FAK/Rho/cytoskeleton signaling.
[Nature Communications] |
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| Researchers showed that cell sensing of external forces and of passive mechanical parameters could be understood through mechanisms, driven by the properties under the force of the mechanosensing molecules involved.
[Nature Communications] |
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| Scientists demonstrated that peripheral circulating NK cells differentiated down two divergent pathways within the tumor microenvironment, resulting in different end states.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators demonstrated that profiling functional proteins involved in cell-to-cell interactions in the microenvironment could predict recurrence and overall survival.
[Communications Biology] |
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| The authors demonstrated that astrocyte-like cells could be derived from adult human gingiva mesenchymal stem cells and used for Tissue-Engineered-rostral migratory stream fabrication.
[Communications Biology] |
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| Researchers developed a tumor microenvironment-based seven-gene prognostic stratification system to predict the prognosis of patients with high-risk endometrial cancer and guide more effective immunotherapy strategies.
[Molecular Therapy-Oncolytics] |
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| Scientists fabricated a 3D scaffold-based on poly (L-lactic acid)/Polycaprolactone matrix polymer containing gelatin nanofibers and gold nanoparticles as the scaffold for bone tissue engineering application.
[Scientific Reports] |
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| To understand the synergistic impact matrix metalloproteinases (MMPs) had on cartilage biomechanical properties, MMPs from two subfamilies: collagenase (MMP-1) and gelatinase (MMP-9) were investigated in this study.
[Scientific Reports] |
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| The authors review convergent and disparate metabolic networks regulated by oncogenic mutant KRAS in colon, lung, and pancreas tumors, with an emphasis on co-occurring mutations and the role of the tumor microenvironment.
[Nature Reviews Cancer] |
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| Investigators review how cell fate decisions are regulated by components of the microenvironment during mammary gland development and how pathological changes in the microenvironment can alter cell fates, leading to malignancy.
[Developmental Cell] |
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| Researchers review the composition, structure, and function of the ECM in cutaneous homeostasis, inflammatory skin diseases such as psoriasis and atopic dermatitis as well as infections as a paradigm for understanding its wider role in human health.
[Frontiers in Cell and Developmental Biology] |
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| Congratulations to Dr. Douglas Philip Dyer! Dr. Dyer undertook his PhD research investigating how an anti-inflammatory protein functions by disrupting the interactions between chemokines and their ECM glycosaminoglycan binding partners.
[International Cytokine and Interferon Society] |
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| September 13 – 15, 2021
Virtual |
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| | University of Rochester – Rochester, New York, United States |
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| | Oregon Health & Science University – Portland, Oregon, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | Springer Nature – Multiple Locations |
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| | University of Arkansas for Medical Sciences – Little Rock, Arkansas, United States |
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