Extracellular Matrix News Volume 12.32 | Aug 26 2021

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    2021-08-26 | ECM 12.32


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 12.32 – 26 August, 2021
    TOP STORY

    Engineered Whole Cut Meat-Like Tissue by the Assembly of Cell Fibers Using Tendon-Gel Integrated Bioprinting

    Investigators demonstrated in vitro construction of engineered steak-like tissue assembled of three types of bovine cell fibers.
    [Nature Communications]

    Full Article


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    PUBLICATIONSRanked by the impact factor of the journal

    Rapid Formation of Multicellular Spheroids in Boundary-Driven Acoustic Microstreams

    A boundary-driven acoustic microstreaming tool is presented that could simultaneously congregate cells and generate sturdy cell clusters through incorporating a bioadhesive such as collagen for rapid production of spheroids.
    [Small]

    Full Article

    Conductive Single-Wall Carbon Nanotubes/Extracellular Matrix Hybrid Hydrogels Promote the Lineage-Specific Development of Seeding Cells for Tissue Repair through Reconstructing an Integrin-Dependent Niche

    A hybrid hydrogel was developed by incorporating single-wall carbon nanotubes into heart-derived extracellular matrixes.
    [Journal of Nanobiotechnology]

    Full ArticleGraphical Abstract

    Spatiotemporal Extracellular Matrix Modelling (StEMM) for In Situ Cell Niche Studies

    Researchers developed an in situ representation of the cardiac ECM that was useful for assessment of repopulation dynamics and to study the effect of local ECM composition on phenotype preservation of reseeded mesenchymal progenitor cells.
    [Stem Cells]

    Abstract

    Histone Deacetylase 4 Controls Extracellular Matrix Production in Orbital Fibroblasts from Graves’ Ophthalmopathy Patients

    Scientists studied the expression of histone deacetylases as well as their contribution to ECM production in orbital fibroblasts.
    [Thyroid]

    Full Article

    Consistent Tumorigenesis with Self-Assembled Hydrogels Enables High-Powered Murine Cancer Studies

    The authors demonstrated a method for tumor inoculation using self-assembled hydrogels to reliably generate tumors with low variance in growth.
    [Communications Biology]

    Full Article

    Angiogenic Microspheres for the Treatment of a Thin Endometrium

    Investigators developed a novel angiogenic hydrogel microsphere based on methacrylated hyaluronic acid loaded with VEGF for the treatment of a thin endometrium by a microfluidic electrospray technique.
    [ACS Biomaterials Science & Engineering]

    AbstractGraphical Abstract

    Multi-Layered Proteogenomic Analysis Unravels Cancer Metastasis Directed by MMP-2 and Focal Adhesion Kinase Signaling

    Scientists analyzed plasma proteome of colorectal cancer (CRC) patients according to disease progression, HCT116 cancer secretome upon matrix metalloproteinase-2 (MMP-2) knockdown, and publicly available CRC tissue proteome data.
    [Scientific Reports]

    Full Article

    Exploration of Collagen Cavitation Based on Peptide Electrolysis

    Under the action of the electric field using NaCl as the supporting electrolyte, the effect of electrolysis on Glycyl-glycine, gelatin and 3D rawhide collagen were determined.
    [Scientific Reports]

    Full Article

    Syncytialization Alters the Extracellular Matrix and Barrier Function of Placental Trophoblasts

    The authors characterized the ECM of an in vitro model of the placental barrier using syncytialized BeWo choriocarcinoma cells.
    [American Journal of Physiology-Cell Physiology]

    Abstract

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    REVIEWS

    Microglia as Hackers of the Matrix: Sculpting Synapses and the Extracellular Space

    Scientists provide an overview of the microglial regulation of synapses, perisynaptic matrix, and perineuronal nets, propose candidate mechanisms by which these structures may be modified, and present the implications of such modifications in normal brain homeostasis and in disease.
    [Cellular & Molecular Immunology]

    Full Article

    Extracellular Matrix Extraction Techniques and Applications in Biomedical Engineering

    The authors focus on the detailed methodology of diverse decellularization techniques for various organs of different animals, and the biomedical applications employing the decellularized ECM.
    [Regenerative Medicine]

    Abstract

    INDUSTRY AND POLICY NEWS

    Blade Therapeutics Announces FDA Activation of IND Application to Investigate Cudetaxestat, a Non-Competitive Autotaxin Inhibitor, in Idiopathic Pulmonary Fibrosis (IPF)

    Blade Therapeutics, Inc. announced that the FDA has activated the Company’s Investigational New Drug application to investigate cudetaxestat in IPF.
    [Blade Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    Angiogenesis: Molecular Mechanisms and Functional Interactions

    September 24 – 27, 2021
    Kloster Seeon, Germany

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Associate – Tumor Microenvironment

    Duke University – Durham, North Carolina, United States

    Research Associate – Stem Cell Models

    Michigan State University – East Lansing, Michigan, United States

    Clinical Research Associate – Cancers, Diabetes, Cardiovascular Disease

    National University of Ireland Galway – Galway, Ireland

    Research Associate – Protein Engineering

    Revel Pharmaceuticals – San Francisco, California, United States

    Development Engineer – Cell Therapies and Regenerative Medicine

    Danaher – Toronto, Ontario, Canada

    > See All Jobs

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