 | | Vol. 12.37 – 7 October, 2021 |
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| Researchers developed 3D printed scaffolds loaded with immunoregulators for enhanced cancer immunotherapy. Compared to the traditional hydrogel, the 3D-scaffold with porous structure endowed similar functions compared with real lymphoid organs by recruitment of a great number of immune cells.
[Advanced Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists implemented EcoTyper, a machine-learning framework integrating transcriptome deconvolution and single-cell RNA sequencing, to characterize clinically relevant diffuse large B cell lymphoma cell states and ecosystems.
[Cancer Cell] |
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| By functionally interrogating cancer-associated fibroblasts heterogeneity using the same therapeutics received by patients, the authors identified three functional subtypes: robustly protective of cancers and highly expressing HGF and FGF7; moderately protective of cancers and highly expressing FGF7; and those providing minimal protection.
[Cancer Cell] |
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| Investigators showed that hyaluronan backbones grafted with lubricin-like sulfonate-rich polymers or with lipid-like phosphocholine-rich polymers together enhanced cartilage regeneration in a rat model of early osteoarthritis.
[Nature Biomedical Engineering] |
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| Inspired by the biophysical cues of ECM, scientists developed an electromechanical coupling bio-nanogenerator (bio-NG) composed of highly discrete piezoelectric fibers. The unique 3D space in the bio-NGs provided an ECM-like growth microenvironment for cells.
[Science Advances] |
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| The authors designed PEGylated lipid nanoparticles loaded with a non-opioid analgesic, bupivacaine, to target neurons within breast cancer tumors and suppress nerve-to-cancer cross-talk.
[Science Advances] |
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| Researchers developed a comprehensive and highly tuneable ex vivo model of pancreatic ductal adenocarcinoma based on the 3D co-assembly of peptide amphiphiles with custom ECM components.
[Nature Communications] |
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| Investigators revealed a short 80 amino-acid peptide (Pegasus) which enhanced Wingless/Wnt1 protein short-range diffusion and signaling. Pegasus was secreted, and co-localized and co-immunoprecipitated with Wingless, suggesting their physical interaction.
[Nature Communications] |
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| Researchers demonstrated that an increased physical rigidity of a fibroblast’s environment was sufficient to evoke stromal autophagy. Mechanistically, matrix stiffness was transmitted via Integrin αV receptors and focal adhesion kinase, resulting in stabilization of AMPK at focal adhesion structures.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Human malignant cells distributed in the bioreactor system mimicking the spatial distribution found in native bone marrow tissue, where most hematopoietic stem and progenitor cells remained linked to the niches and mature cells were released to the circulation.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Airway epithelial patches were engineered by differentiating human iPSC-derived airway progenitors into physiological proportions of ciliated and goblet cells on a silk fibroin–collagen vitrigel membrane composite biomaterial for transplantation in porcine tracheal defects ex vivo and in vivo.
[Advanced Healthcare Materials] |
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| Gingiva-derived mesenchymal stem cells (GMSCs) under 3D-culture in soft collagen hydrogel showed significantly increased expression of a panel of genes related to development/differentiation of neural crest stem-like cells and/or Schwann cell precursor-like cells.
[NPJ Regenerative Medicine] |
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| The authors exploited atovaquone/albumin nanoparticles to improve bioavailability and tumor targeting of atovaquone, enhancing the efficacy of anti-PD-1 therapy by normalizing tumor hypoxia.
[Journal of Nanobiotechnology] |
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| Investigators conceptualize how synthetic biology approaches can be applied to program living cells with therapeutic functions and discuss the advantages that they offer over conventional therapies in terms of flexibility, specificity and predictability, as well as challenges for their development.
[Nature Reviews Drug Discovery] |
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| The authors discuss the immune modulatory functions of microglia, monocyte-derived macrophages and astrocytes in brain metastases and glioma.
[Nature Reviews Cancer] |
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| Scientists synthesize literature published in the past two years on the role of non-coding RNAs in osteoarthritis and rheumatoid arthritis with a focus on inflammation, cell death, cell proliferation and ECM dysregulation.
[Nature Reviews Rheumatology] |
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| Surface Oncology, an immuno-oncology company developing next-generation immunotherapies that target the tumor microenvironment, announced details about its plan to initiate a randomized Phase II clinical study evaluating SRF388 in patients with treatment-naïve hepatocellular carcinoma.
[Surface Oncology] |
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| October 4 – 6, 2021
Virtual |
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| | Colorado State University – Fort Collins, Colorado, United States |
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| | University of Liverpool – Liverpool, England, United Kingdom |
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| | The International Society for Cell & Gene Therapy – Vancouver, British Columbia, Canada |
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| | Moores Cancer Center, UC San Diego – San Diego, California, United States |
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| | University of Southern California – Los Angeles, California, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
