 | | Vol. 12.40 – 28 October, 2021 |
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| Investigators found that structural dynamics of neurokinin-1 receptor agonists depended on interactions with the receptor extracellular loops and regulated G protein signaling selectivity.
[Nature Chemical Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed in mouse melanoma and breast cancer models that regulatory T cells expressing the β8 chain of αvβ8 integrin were the main cell type in the tumors that activated TGFβ, produced by the cancer cells and stored in the tumor microenvironment.
[Nature Communications] |
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| Researchers developed a material and culture system for modifying and measuring the degree to which cells retained cumulative effects of mechanosensing.
[Nature Communications] |
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| Investigators indicated that elevated TGFβ signaling led to an attenuated response to growth factors, which contributed to impaired dermal wound healing in recessive dystrophic epidermolysis bullosa.
[Matrix Biology] |
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| A chondrogenic collagen-chondroitin sulfate scaffold was tested in an orthotopic lapine in vivo model to understand the beneficial effects of the immunomodulatory biomaterial on full chondral defect.
[Advanced Healthcare Materials] |
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| Researchers investigated the use of a decellularized, porcine nerve-derived hydrogel filler for conduits in an 8 milimeter rat sciatic nerve gap model. The decellularized tissue maintained multiple nerve-specific matrix components and nerve growth factors.
[NPJ Regenerative Medicine] |
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| Chondrocytes seeded within a a dual crosslinked pullulan-gelatin cryogel scaffold and cultured for 21 days in vitro demonstrated enhanced cell proliferation, enhanced production of cartilage-specific ECM and up-regulated sulfated glycosaminoglycan without altering the articular chondrocyte phenotype.
[Biomaterials Science] |
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| Scientists assessed the Mucin 1-mediated effect of hypoxia on the proteomic composition of human osteoblast-derived ECM and characterized their osteogenic and angiogenic potentials in the produced ECM.
[Journal of Cellular Physiology] |
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| The authors screened various collagen types and observed that the type V collagen α1 chain (COL5A1) gene played a pivotal role in glioblastoma (GBM). They investigated the involvement of COL5A1 in ECM remodeling and the regulation of actin filaments in the metastasis of GBM.
[Cell Death Discovery] |
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| Researchers indicated that RCAN1.4 expression was impaired both in unilateral ureteral obstruction-induced renal fibrosis in vivo and TGF-β1-induced renal fibrosis in vitro. However, knocking in of RCAN1.4 suppressed the production of ECM both in vivo and in vitro.
[Cell Death Discovery] |
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| Scientists tested four methods to decellularize human cardiac tissue and evaluated their efficiency in terms of cell removal and preservation of key ECM components, such as collagens and sulfated glycosaminoglycans.
[Scientific Reports] |
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| Investigators elucidated the role of the stromal microenvironment in SHH-subgroup medulloblastoma and identified novel treatment possibilities for this challenging disease.
[Scientific Reports] |
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| The authors introduce neutrophil extracellular trap formation and discuss the possible neutrophil extracellular trap-related mechanisms in wound healing.
[Cell Death & Disease] |
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| Investigators introduce the mechanism of platelet-related tumor metastasis and particularly focus on the role of cell adhesion molecules in it.
[Critical Reviews in Oncology/Hematology] |
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| Scientists discuss current literature on the effects of radiation on cancer-associated fibroblasts (CAFs) and the influence that CAFs have on radiotherapy outcomes, and summarize present knowledge on the transformed cellular crosstalk between CAFs and immune cells after radiation.
[Journal of Translational Medicine] |
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| Innovent Biologics, Inc. and NeoCura Bio-Medical Technology Co., Ltd. announced that they have entered into a strategic collaboration agreement to carry out a clinical study in China on the combination therapy of sintilimab from Innovent and individualized neoantigen vaccine NEO_PLIN2101 from NeoCura.
[Innovent Biologics, Inc. (PR Newswire, Inc.)] |
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| GenFleet Therapeutics announced the first patient with metastatic sigmoid adenocarcinoma has been dosed in a Phase Ib/II trial of GFH018 in combination with toripalimab as part of global multi-center clinical research. There are broad indications for GFH018 in treating solid tumors with lower response rates to PD-1 inhibitors.
[GenFleet Therapeutics] |
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| November 8 – 10, 2021
Virtual |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Malmö, Sweden – Lund University |
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| | Columbia University – New York, New York, United States |
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| | Cedars-Sinai Medical Center – Los Angeles, California, United States |
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| | Duke University – Durham, North Carolina, United States |
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