 | | Vol. 12.43 – 25 November, 2021 |
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| The authors suggested that a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS) proteases were critical for versican degradation in the heart and that versican accumulation was associated with impaired cardiac function.
[Circulation] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Overexpression of C1q/TNF-related protein-3 (CTRP3) enhanced the progression of tendinopathy by accumulating cartilaginous proteoglycans and degenerating collagenous fibers in the mouse tendon, whereas CTRP3 knockdown suppressed the tendinopathy pathogenesis.
[Science Advances] |
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| Researchers reported a collective cell reorientation cascade in growing Vibrio cholerae biofilms that led to a differentially ordered, spatiotemporally coupled core-rim structure reminiscent of a blooming aster.
[Nature Communications] |
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| Investigators developed a cell-adhesive fiber-forming peptide that mimicked the jigsaw-shaped hydrophobic surface in the dovetail-packing motif of glycophorin A as an artificial ECM for regenerative therapy.
[Nature Communications] |
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| Scientists indicated that blocking C3aR signaling in natural killer (NK) cells increased NK-cell infiltration into the tumor microenvironment in mouse models and led to tumor regression.
[Cancer Immunology Research] |
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| In the type 1 diabetic NOD mouse model, engineered growth factors improved both re-epithelialization and granulation tissue formation.
[NPJ Regenerative Medicine] |
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| Extracellular vesicles derived from human articular chondrocytes induced a chondrogenic phenotype characterized by marked induction of SOX9, COMP, Aggrecan, and Collagen type II, and matrix glycosaminoglycans synthesis.
[NPJ Regenerative Medicine] |
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| Through immunohistochemistry and inducible gene deletion, researchers found that the recruitment of stem/progenitor cells into degenerative mutant tendons originated from a Sox9-expressing lineage and their recruitment was dependent on cell autonomous TGFβ signaling.
[Stem Cell Reports] |
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| The authors analyzed the alteration of collagen and gene expression profiles in pancreatic cancer tissues after neoadjuvant therapy. They examined the biological role of Ephrin-A5 using primary cultured cancer-associated fibroblasts.
[British Journal of Cancer] |
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| Scientists designed and synthesized a new indazole derivative XBLJ-13, and identified XBLJ-13 as a highly specific and potent DDRs inhibitor with anti-inflammation and anti-fibrosis activities.
[Acta Pharmacologica Sinica] |
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| Researchers investigated the anti-cancer activity of the mitochondrial complex I inhibitor intervenolin, which modulated the tumor microenvironment independent of energy depletion.
[iScience] |
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| Investigators demonstrated that matrix metalloproteinase 11 (MMP11) expression in mononuclear inflammatory cells was an independent negative prognostic factor in breast cancer, whereas MMP11 expression in tumor cells and fibroblasts was not associated with patient survival.
[Laboratory Investigation] |
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| Using B16 mouse melanoma and CT26 colon carcinoma as models of stroma-poor tumors, researchers demonstrated that myeloid/dendritic cells were the main sources of TGFβ1 and TGFβ3.
[Communications Biology] |
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| The authors suggest that a better understanding of human host stroke tissue–hydrogel interactions in addition to the effects of scaling up hydrogel volume to human-sized cavities would help guide the translation of second-generation regenerative stroke therapies.
[Trends in Biotechnology] |
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| Scientists present current achievements in the development of small molecular drugs for cartilage regeneration, particularly in the fields of chondrocyte generation and reversion of chondrocyte degenerative phenotypes.
[Cellular and Molecular Life Sciences] |
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| To investigate and clarify the role of ECM in the regulation of cancer cell behavior and response to therapy, the decellularization of ECM, a widely used technique in tissue engineering, has been recently employed to develop 3D culture model of disease.
[Cancer Gene Therapy] |
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| CoImmune, Inc. announced a research collaboration with Yeda Research and Development Company Ltd. to evaluate the applications of the Synthetic Immune Niche technology, developed by Weizmann Institute’s researchers to enhance the expansion and function of human cytokine induced killer cells expressing chimeric antigen receptors.
[CoImmune, Inc. (GlobeNewswire, Inc.)] |
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| At the Magee-Womens Summit, Magee-Womens Research Institute (MWRI) awarded the $1 million Magee Prize to an international team led by Dr. Pamela Moalli director of urogynecology and pelvic reconstruction surgery at UPMC Magee-Womens Hospital and MWRI.
[Magee-Womens Research Institute and Foundation] |
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| December 8 – 9, 2021
Virtual |
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| | University of Washington – Seattle, Washington, United States |
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| | Houston, Texas, United States – Baylor College of Medicine |
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| | Genentech – San Francisco, California, United States |
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| | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| | Oregon Health & Science University – Portland, Oregon, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
