 | | Vol. 12.44 – 2 December, 2021 |
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| Coculturing chondrocytes with mesenchymal stem cells (MSCs) derived from gingival lamina propria produced abundant “matrix-bound gingival MSC derived extracellular vesicles” in forming cartilaginous ECM (cECM), which were further preserved in acellular cECM following mild, short-period decellularization.
[Advanced Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors identified putative mechanisms of enthesis toughening in a mouse model and then manipulated these mechanisms via in vivo control of mineralization and architecture.
[Science Advances] |
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| To probe the role of B cells in biomaterial scaffold response, scientists evaluated the B cell response to biomaterial materials implanted in a muscle wound using a biological ECM as a reference for a naturally derived material, and synthetic polyester polycaprolactone as a reference for a synthetic material.
[Science Advances] |
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| Researchers developed a bioink, termed as “microbial ink” that was produced entirely from genetically engineered microbial cells, programmed to perform a bottom-up, hierarchical self-assembly of protein monomers into nanofibers, and further into nanofiber networks that comprised extrudable hydrogels.
[Nature Communications] |
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| Using breast cancer as a model of solid tumor metastasis to the bone marrow, the authors applied large-scale quantitative 3D imaging to characterize temporal changes in the bone marrow microenvironment during disease progression.
[Nature Communications] |
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| Investigators presented the development of a 2D MXene-based hydrogel system for highly efficient photo- and magnetic-responsive drug delivery oriented to deep chronic wound repair.
[Small] |
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| Scientists proved that anlotinib facilitated tumor vessel normalization at least partially through CD4+ T cells, reprogrammed the immunosuppressive tumor microenvironment (TME) into an immunostimulatory TME, significantly inhibited tumor growth and effectively prevented systemic immunosuppression.
[Clinical Cancer Research] |
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| For key structural factors within the nucleus and ECM, the authors discovered specific gene-gene scaling exponents across many of the 32 tumor types in The Cancer Genome Atlas, and they demonstrated utility in predicting patient survival as well as scaling-informed machine learning.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers expressed doublecortin (DCX) in human adipose-derived stromal/stem cells (hASCs) and engineered hASCs into cartilage tissues. They found that DCX expression in hASCs increased expression of growth differentiation factor 5 and matrilin 2 in the engineered cartilage tissues.
[NPJ Regenerative Medicine] |
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| Scientists investigated the functional role of hepatic stellate cell ferroptosis in the anti-fibrotic effect of sorafenib and found that sorafenib attenuated liver injury and ECM accumulation in CCl4-induced fibrotic livers, accompanied by reduction of SLC7A11 and GPX4 proteins.
[Cell Proliferation] |
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| Human tumor samples and in vivo patient-derived xenograft and syngeneic murine models were administered Wnt/β-catenin modulating agents DKN-01 and CGX-1321 individually or in sequence
[Gynecological Oncology] |
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| Co-cultured using a magnetic spheroid formation approach, conditionally immortalised human podocytes and glomerular endothelial cells deposited mature, organized isoforms of collagen IV and Laminin.
[Communications Biology] |
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| Investigators demonstrated marker expression and matrix competency of cardiac fibroblasts developed through a developmentally conserved epicardial pathway as shown next to primary human cardiac fibroblasts.
[Journal of Molecular and Cellular Cardiology] |
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| Bone marrow and cell-dependent scaffolds own distinctive mechanisms for mineral genesis, which makes them methodically, synthetically, and functional disparate. The authors summarize two strategies in regenerative dentistry and orthopedics at the level of mechanisms.
[Advanced Materials] |
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| Investigators outline hematopoietic stem cell (HSC) niche biology, review the role of the different classes of ECM molecules in the niche, and discuss matrix remodeling and the emerging importance of biophysics in HSC niche function.
[Advanced Drug Delivery Reviews] |
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| Scientists summarize the current knowledge of the composition and function of the basement membrane and its matrikines in health and disease, both in the lung and in the kidney.
[Matrix Biology] |
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| Oncotelic Therapeutics, Inc. announced that it has submitted clinical study protocol to the US FDA for the initiation of a Phase II Trial for OT-101, the company’s TGF-β inhibitor, in combination with Anti-PD-1 as a treatment for patients with malignant pleural mesothelioma.
[Oncotelic Therapeutics, Inc.] |
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| PCI Biotech Holding ASA, a cancer-focused biopharmaceutical company with a unique intracellular delivery technology via Photochemical Internalisation and Immunicum AB announced an extension of their current collaboration.
[PCI Biotech Holding ASA] |
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| EpicentRx, Inc., a biotechnology company at the forefront of oncolytic viruses and small molecules for the treatment of cancer and other inflammatory-driven diseases, announced that the US Patent and Trademark Office has issued US Patent No. 10,906,957 entitled “Immunomodulatory Fusion Proteins.”
[EpicentRx, Inc.] |
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| January 9 – 12, 2022
Portland, Oregon, United States |
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| | Centre de recherche du CHUM – Montreal, Quebec, Canada |
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| | University of Washington – Seattle, Washington, United States |
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| | Genentech – San Francisco, California, United States |
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| | Houston, Texas, United States – Baylor College of Medicine |
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| | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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