 | | Vol. 12.45 – 9 December, 2021 |
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| In vivo, scientists identified a new intermediate pancreatic ductal adenocarcinoma transcriptional cell state and uncovered distinct site- and state-specific tumor microenvironments.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported a smart semiconducting polymer nano-immunomodulator in response to acidic tumor microenvironment for precision photodynamic immunotherapy of cancer.
[Advanced Materials] |
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| Investigators showed that collagen deposition in response to the implantation of human split-thickness skin grafts containing live cells recapitulated normal skin architecture, whereas human acellular dermal matrix grafts led to a fibrotic collagen deposition.
[Science Advances] |
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| The development of a bioactive nanocomplex formed along with polydeoxyribonucleotide and bone morphogenetic protein 2 (BMP2) provided synergistic abilities in angiogenesis and bone regeneration.
[Science Advances] |
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| The authors showed that bone marrow sinusoidal endothelial cells (BM-SEC) actively controlled erythropoiesis. While activation of Wnt-signaling in BM-SEC caused an increase in erythroblast subsets, mature erythroid cells were reduced, indicating impairment of terminal erythroid differentiation/reticulocyte maturation.
[Nature Communications] |
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| Scientists reported that the neuronal ECM could be remodeled frequently through mechanisms that involved endocytosis and recycling of ECM proteins.
[Nature Communications] |
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| A microfluidic device with cell-laden methacrylated gelatin bioink and alginate as a matrix hydrogel was used to fabricate a functional hybrid structure laden with cell-aggregated microbeads.
[Small] |
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| Hypoxia-induced amoeboid dissemination occurred through low ECM-adhesive, predominantly bleb-based amoeboid movement, which was maintained by a low-oxidative and -glycolytic energy metabolism.
[Current Biology] |
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| Researchers developed a microfluidic organ-on-chip platform for matrix-based, heterogeneous 3D cultures with fully integrated electrochemical chemo- and biosensor arrays for the energy metabolites oxygen, lactate, and glucose.
[Lab On A Chip] |
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| Scientists demonstrated that stiffness contributed to mechanosignal transduction in hepatic stellate cells, which promoted hepatocellular carcinoma cell growth and metastasis through secretion of FGF2.
[Cell Death & Disease] |
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| Photocrosslinked gelatin hydrogels were imparted with several properties, namely fast wound adherence, strong wet tissue surface adhesion, greater biocompatibility, long-term basic fibroblast growth factor release, and ease of use through the modification and combination of natural bio-macromolecules.
[Scientific Reports] |
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| The association between pulmonary sequelae and markers of disease severity, as well as pro-fibrotic mediators, were studied in 108 patients 3 months after hospital admission for COVID-19.
[Scientific Reports] |
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| A collagen-based, angle-ply multilaminate patch designed to repair the outer annulus fibrosus was assessed for its ability to support mesenchymal stromal and annulus fibrosus cell viability, elongation, alignment, extracellular matrix gene expression, and scaffold remodeling.
[Journal of Biomedical Materials Research Part B-Applied Biomaterials] |
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| The authors review the role of enhancer of zeste homology 2 (EZH2) in regulating bone marrow mesenchymal stem cell differentiation and the immune cell function in the tumor microenvironment and summarize all types of existing EZH2 inhibitors and the main clinical trials.
[Critical Reviews in Oncology/Hematology] |
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| Scientists review recent advances in biomineralization-inspired materials developed for hard tissue repair and summarize the advantages and limitations of these materials.
[International Journal of Oral Science] |
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| Investigators review apicobasal crosstalk of two well-established models of membrane remodeling taking place during Drosophila melanogaster embryogenesis: amnioserosa cell shape oscillations during dorsal closure and subcellular tube formation in tracheal cells.
[Biology Open] |
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| G1 Therapeutics, Inc. announced that the company has initiated a Phase II, single arm, open-label study of trilaciclib in patients with early-stage triple negative breast cancer designed to further investigate the role of trilaciclib in modulating the anti-tumor immune response.
[G1 Therapeutics, Inc.] |
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| InteRNA Technologies announced it received Investigational New Drug clearance from the US FDA for the company’s Phase I clinical trial evaluating lead miRNA candidate, INT-1B3, in patients with advanced solid tumors.
[InteRNA Technologies] |
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| January 21 -23, 2022
Austin, Texas, United States |
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| | Cedars-Sinai Regenerative Medicine Institute – Los Angeles, California, United States |
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| | The CHUM Research Centre – Montreal, Quebec, Canada |
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| | University of Washington – Seattle, Washington, United States |
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| | Genentech – San Francisco, California, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
