Extracellular Matrix News Volume 12.46 | Dec 16 2021

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    2021-12-16 | ECM 12.46


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 12.46 – 16 December, 2021
    TOP STORY

    Nanoscale CaH2 Materials for Synergistic Hydrogen-Immune Cancer Therapy

    Researchers prepared CaH2 nanoparticles through liquid-phase exfoliation and first applied them as an antitumor therapeutic agent.
    [Chem]

    AbstractGraphical Abstract
    Dr. Kristina McBurney and Leanna Bedell discuss how you can use social media to advance your scientific career. Watch now.
    PUBLICATIONSRanked by the impact factor of the journal

    A Tough Nitric Oxide-Eluting Hydrogel Coating Suppresses Neointimal Hyperplasia on Vascular Stent

    Investigators developed a nitric oxide-eluting hydrogel coating for vascular stents inspired by the biological functions of nitric oxide for cardiovascular system.
    [Nature Communications]

    Full Article

    Engineering Bacillus subtilis for the Formation of a Durable Living Biocomposite Material

    Scientists engineered B. subtilis to become a living component of a silica material composed of self-assembling protein scaffolds for functionalization and cross-linking of cells.
    [Nature Communications]

    Full Article

    Parity-Induced Changes to Mammary Epithelial Cells Control NKT Cell Expansion and Mammary Oncogenesis

    The authors illustrated how pregnancy-induced changes modulated the communication between mammary epithelial cells and the immune microenvironment and established a causal link between pregnancy, the immune microenvironment, and mammary oncogenesis.
    [Cell Reports]

    Full ArticlePress ReleaseGraphical Abstract

    Migratory Chondroprogenitors Retain Superior Intrinsic Chondrogenic Potential for Regenerative Cartilage Repair as Compared to Human Fibronectin Derived Chondroprogenitors

    Researchers compared human fibronectin adhesion assay-derived chondroprogenitors with migratory chondroprogenitors in normoxic and hypoxic culture conditions, investigating their growth characteristics, surface marker profile and trilineage potency.
    [Scientific Reports]

    Full Article

    In Vivo Biocompatibility Evaluation of In Situ-Forming Polyethylene Glycol-Collagen Hydrogels in Corneal Defects

    In both clinical and histologic observations, epithelial cells were able to migrate and form multilayers over the polyethylene glycol-collagen hydrogels at the site of the corneal stromal defect.
    [Scientific Reports]

    Full Article

    Optimal Delipidation Solvent to Secure Extracellular Matrix from Human Perirenal Adipose Tissue

    Investigators evaluated the delipidation efficiency of acetone, chloroform, methanol, ether, ethanol, isopropanol, water, chloroform/methanol, ethanol/heptane, ether/methanol, hexane/ethanol, and butanol/methanol solvents for ECM extraction from human perirenal adipose tissue.

    ncRNA KCNQ1OT1 Regulated High Glucose-Induced Proliferation, Oxidative Stress, Extracellular Matrix Accumulation, and Inflammation by miR-147a/SOX6 in Diabetic Nephropathy (DN)

    Knockdown of potassium voltage-gated channel subfamily Q member 1 overlapping transcript 1 (KCNQ1OT1) suppressed proliferation, ECM accumulation, inflammation, and oxidative stress in high glucose-cultured human glomerular mesangial cells in vitro.
    [Endocrine Journal]

    Abstract

    A Tumor-Derived Type III Collagen-Rich ECM Niche Regulates Tumor Cell Dormancy

    Investigators studied how disseminated tumor cells sensed and remodeled the ECM to sustain dormancy.
    [Nature Cancer]

    Abstract
    Guide to everything you need to know about cell separation.
    REVIEWS

    Current Hydrogel Advances in Physicochemical and Biological Response-Driven Biomedical Application Diversity

    Scientists concisely introduce the physicochemical properties of hydrogels and their fabrication approaches.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Towards Organoid Culture without Matrigel

    The authors discuss promising Matrigel-free methods for the generation and maintenance of organoids that use decellularized ECM, synthetic hydrogels, or gel-forming recombinant proteins.
    [Communications Biology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Over £1 Million Awarded to New PhD Studentships

    The NC3Rs announced they awarded £1.08 million to ten new PhD Studentship projects, embedding the 3Rs in the training of the next generation of scientific researchers.
    [The NC3Rs]

    Press Release
    FEATURED EVENT

    Immuno US

    February 7 – 8, 2022
    San Diego, California, United States

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    JOB OPPORTUNITIES

    Postdoctoral Researcher – Extracellular Vesicles

    Vanderbilt University Medical Center – Nashville, Tennessee, United States

    Research Associate – Cardiovascular Disease Modeling

    Cedars-Sinai Regenerative Medicine Institute – Los Angeles, California, United States

    Research Professor – Burn Care and Regenerative Medicine

    Centre de recherche du CHUM – Montreal, Quebec, Canada

    Postdoctoral Fellow – Mechanisms Underlying Prostate Tissue Homeostasis

    University of Washington – Seattle, Washington, United States

    Postdoctoral Associate – Cancer Immunotherapy

    Houston, Texas, United States – Baylor College of Medicine

    > See All Jobs

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