 | | Vol. 13.00 – 6 January, 2022 |
| |
|
|
| Investigators reported that a hydrogel serving as a high-capacity drug depot and combining a dissipative tough matrix on one side and a chitosan adhesive surface on the other side supported tendon gliding and strong adhesion to tendon on opposite surfaces of the hydrogel.
[Nature Biomedical Engineering] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists constructed a cocktail therapy to simultaneously regulate the osteoblast/osteoclast and M1/M2 macrophage balance.
[ACS Nano] |
|
|
|
| In Ppara−/− mice, the authors found that an increased de novo lipogenesis stimulated cartilage degradation and identified ACOT12 as a key regulatory factor.
[Nature Communications] |
|
|
|
| Researchers utilized a bone morphogenetic protein-2-loaded scaffold to create periosteum-like tissue in vivo, mimicking the mesenchymal condensation during native long bone development.
[Bone Research] |
|
|
|
| Scientists engineered a SASC system which mimicked the paracrine effect of the stem cell secretome and provided tailorability of the composition for targeted tissue regeneration.
[Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| Tailored to specific features of tumor microenvironment (TME), investigators developed a biosafe, stable and TME-activated theranostic nanoplatform for photoacoustic imaging and self-amplified cooperative therapy.
[Theranostics] |
|
|
|
| A conductive and injectable hydrogel crosslinked by matrix metalloproteinase (MMP)-sensitive peptides was rationally constructed to stabilize hypoxia-inducible factor-1α (HIF-1α) to recover heart functions after myocardial infarction.
[Theranostics] |
|
|
|
| The authors confirmed that CXCL4 directly induced myofibroblast differentiation and collagen synthesis in different precursor cells, including endothelial cells, by stimulating endothelial-to-mesenchymal transition.
[Cell Reports] |
|
|
|
| Researchers found that the level of lactate dehydrogenase A (LDHA) was significantly elevated in aortic dissection patients and the mouse model established by BAPN combined with Angiotensin II.
[Pharmacological Research] |
|
|
|
| Investigators proposed a 3D environment based on gallic acid grafted-chitosan scaffold and osteoblasts differentiated from human umbilical cord mesenchymal stem cells to recapitulate the main components of hematopoietic stem cells niche.
[Stem Cell Reviews and Reports] |
|
|
|
| The authors established the ability of the polyphenol compound epigallocatechin gallate, a principal component of green tea, to facilitate the extracellular formation of elastin fibers in vascular smooth muscle cells derived from human induced pluripotent stem cells.
[Journal of Molecular and Cellular Cardiology] |
|
|
|
| Scientists demonstrated a new strategy for constructing functional tissue-engineered skin with minimal functional unit of skin as the source of bioactivity.
[Macromolecular Bioscience] |
|
|
|
| Researchers probed the use of new biomimetic sulphonated polyether ether ketone-based nanofibrous scaffold to deliver amine functionalized hydroxyapatite nanoparticles loaded resveratrol for its potent functionality in osteogenic differentiation.
[Journal of Biomaterials Science-Polymer Edition] |
|
|
|
|
| The authors summarize the current evidence on the role of TGFβ signaling in myocardial diseases, focusing on cellular targets and molecular mechanisms, and discuss challenges and opportunities for therapeutic translation.
[Nature Reviews Cardiology] |
|
|
|
| Scientists explore potential tumor microenvironment metabolic determinants that might constitute candidate targets for cancer immunotherapies, ideally leading to future strategies for reprogramming tumor metabolism to potentiate anticancer T cell functions.
[Trends in Immunology] |
|
|
|
| Investigators describe the pro-tumorigenic roles of lipid uptake, metabolism and synthesis and detail the therapeutic potential of targeting lipid metabolism in cancer.
[Cellular & Molecular Immunology] |
|
|
|
|
| Weill Cornell Medicine researchers have received a two-year $500,000 grant from JDRF to evaluate an innovative approach to islet cell transplantation, an experimental treatment for difficult-to-control type 1 diabetes.
[Weill Cornell Medicine] |
|
|
|
| BioRestorative Therapies, Inc. announced that it has been awarded a Small Business Technology Transfer (STTR) Phase I grant for $256,000 to evaluate the therapeutic effects on the company’s hypoxic cultured bone marrow-derived mesenchymal stem cells after encapsulation with a PEG-peptide hydrogel.
[BioRestorative Therapies, Inc. (Globe Newswire, Inc.)] |
|
|
|
|
| February 7-9, 2022
Lyon, France |
|
|
|
|
|
| Baylor College of Medicine – Houston, Texas, United States |
|
|
|
| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
|
|
|
| University of Cincinnati – Cincinnati, Ohio, United States |
|
|
|
| | Vanderbilt University Medical Center – Nashville, Tennessee, United States |
|
|
|
| | The University of Manchester – Manchester, United Kingdom |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
