 | | Vol. 13.01 – 13 January, 2022 |
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| Investigators deployed engineered biomaterials as a scaffold to increase tumor formation rate, decrease disease latency, and diminish variability of immune infiltrates into tumors formed from murine mammary carcinoma cell lines implanted into syngeneic mice.
[Advanced Materials] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers developed a tumor-conditional interleukin-12 (pro-IL-12), which masked IL-12 with selective extracellular receptor–binding domains of the IL-12 receptor while preferentially and persistently activating tumor-infiltrating lymphocytes after being unmasked by matrix metalloproteinases expressed by tumors.
[Science Immunology] |
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| The authors reported that mechanical stiffening of ECM attenuated the epithelial defense against HRasV12-transformed cells.
[Nature Communications] |
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| Scientists investigated the role of macrophage LC3-associated phagocytosis within the bone marrow microenvironment of acute myeloid leukemia.
[Journal of Clinical Investigation] |
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| Researchers described an in vitro model of the human blood–brain barrier self-assembled within microfluidic devices from stem-cell-derived or primary brain endothelial cells, and primary brain pericytes and astrocytes.
[Nature Protocols] |
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| Using the Drosophila follicular epithelium, the authors showed that kinesin-3 and kinesin-1 motors worked together to define this secretion site.
[Current Biology] |
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| A bioinspired grid-crimp micropattern fabricated by melt electrospinning writing was proposed to mimic the native structure of bone-ligament interface.
[Biofabrication] |
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| Scientists presented a 3D hanging spheroid plate, which facilitated the formation of spheroids and the separation of unbound and dead cells from spheroids during cytotoxicity assays.
[Journal of Nanobiotechnology] |
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| Human Crohn’s disease (CD) tissue samples were gained from patients with CD who underwent surgical resection of the intestine and were defined as stenotic or nonstenotic areas.
[Inflammatory Bowel Diseases] |
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| Scientists used an integrative computational-experimental approach to elucidate the natural history of neovessel formation in a large animal preclinical model.
[Communications Medicine] |
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| The study of the coagulome provides unprecedented opportunities to explore the tumor microenvironment and to better predict the hemostatic complications.
[Trends in Cancer] |
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| The authors summarize the state-of-the-art research on articular cartilage-derived progenitor cells for use in cartilage repair therapies.
[NPJ Regenerative Medicine] |
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| Scientists discuss bone structure, properties of an ideal scaffold, the potential of decellularized bone as bioscaffolds, terminal sterilization of decellularized bone, cell removing confirmation in decellularized tissues, and post decellularization procedures.
[Journal of Biological Engineering] |
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| A collaborative research team led by David Mooney, John A. Paulson School of Engineering and Applied Sciences, Eckhard Weber at the Novartis Institutes for BioMedical Research, and Daniel Kaufman, developed a new biomaterial-based tendon therapy that addresses key challenges in the regeneration process.
[Wyss Institute] |
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| NOXXON Pharma N.V. announced that the Data Safety Monitoring Board positively evaluated safety data from the initial four weeks of treatment of the first patient enrolled in the GLORIA clinical trial expansion arm.
[NOXXON Pharma N.V.] |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | Cedars-Sinai Medical Center – Los Angeles, California, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| University of Cincinnati – Cincinnati, Ohio, United States |
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