 | | Vol. 13.02 – 20 January, 2022 |
| |
|
|
| Scientists demonstrated that a biodegradable piezoelectric poly(L-lactic acid) nanofiber scaffold under applied force or joint load could act as a battery-less electrical stimulator to promote chondrogenesis and cartilage regeneration.
[Science Translational Medicine] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Investigators quantified tumor infiltration across two distinct clear cell renal cell carcinoma patient tumor cohorts using complementarity determining region-3 (CDR3) sequence recovery counts in tumor-infiltrating lymphocytes and a generalized diversity index for CDR3 sequence distributions.
[Cancer Research] |
|
|
|
| The authors evaluated the efficacy of intraarticular injections of amnion membrane hydrogels with and without adipose-derived stem cells in reducing inflammation and cartilage degeneration in a collagenase-induced osteoarthritis rat model.
[Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| Researchers developed an “off-the-shelf” adipose ECM biomaterial from allograft human tissue, applying physical and chemical processing methods to remove lipids and create an injectable matrix that mimicked the properties of lipoaspirate.
[NPJ Regenerative Medicine] |
|
|
|
| Using single-cell RNA-seq, scientists identified macrophages as a source of matrix metalloproteinase 14 in muscle following a hypertrophic exercise stimulus in mice.
[FASEB Journal] |
|
|
|
| Investigators reported a hybrid nanoink composed of alginate, gelatin methacryloyl, and cellulose nanocrystal, designed for multinozzle microextrusion 3D printing of tumor models.
[ACS Biomaterials Science & Engineering] |
|
|
|
| Researchers suggested that reconstructing the basement membrane promoted secretion of platelet-derived growth factor consisting of two B subunits by epidermal keratinocytes, leading to increased collagen expression at the papillary dermis.
[Scientific Reports] |
|
|
|
| The authors investigated subretinal fibrosis in the laser photocoagulation model of choroidal neovascularization (CNV) by studying the whole transcriptome of the retinal pigment epithelium/choroid following CNV and the application of an anti-fibrotic following CNV.
[Scientific Reports] |
|
|
|
| Using a rat cervical hemicontusion model, investigators evaluated the survival and integration of human induced pluripotent stem cell-derived spinal motor neurons and oligodendrocyte progenitor cells.
[Frontiers in Cellular Neuroscience] |
|
|
|
| Scientists prepared inks that exhibited excellent shear-thinning behavior, which contributed to extrusion-based printing, and also showed good crosslinking ability by calcium chloride.
[Macromolecular Bioscience] |
|
|
|
| Polymer complex gels of sacran with cell-compatible proteins and collagen were prepared. Complex gels of sacran and collagen were observed using fluorescence and polarized microscopes, which indicated the complexation characteristics of sacran and collagen, as well as their partial orientation.
[Polymer Journal] |
|
|
|
| Through investigating chronic kidney disease-associated transcriptomics datasets, several proteases were highlighted including members of matrix metalloproteinases and serine proteases.
[PLoS One] |
|
|
|
|
| The authors propose an architecture for such a joint-on-chip (JoC) platform, discuss the status of the engineering of individual joint tissues and the efforts to combine them in a functional JoC model and identify unresolved issues and challenges in constructing an accurate, physiologically relevant system.
[Nature Reviews Rheumatology] |
|
|
|
| Investigators highlight the role of the Golgi in the formation of an adaptable, healthy matrix, with a focus on proteoglycan and procollagen secretion as example cargoes.
[Journal of Cell Science] |
|
|
|
|
| Xilio Therapeutics, Inc. announced that the first patient has been dosed in the company’s Phase I/II clinical trial evaluating XTX202 for the treatment of solid tumors. XTX202 is a modified form of IL-2 that is designed to localize activity in the tumor microenvironment.
[Xilio Therapeutics, Inc.] |
|
|
|
|
|
|
|
| | Mayo Clinic Florida Campus – Jacksonville, Florida, United States |
|
|
|
| | Luxembourg Institute of Health – Luxembourg, Luxembourg |
|
|
|
| | Boston Children’s Hospital – Boston, Massachusetts, United States |
|
|
|
| | Stanford University – Stanford, California, United States |
|
|
|
| | Vanderbilt University Medical Center – Nashville, Tennessee, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
