 | | Vol. 13.04 – 3 February, 2022 |
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| Researchers proposed that lactic acid in the highly glycolytic tumor microenvironment (TME) was an active checkpoint for the function of regulatory T cells in the TME via upregulation of PD-1 expression.
[Cancer Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that, upon irradiation, interleukin-1α triggered oxidative DNA damage, thereby predisposing inflammatory cancer associated fibroblasts to p53-mediated therapy-induced senescence, which in turn resulted in chemoradiotherapy resistance and disease progression.
[Cancer Cell] |
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| The authors reported that HCV infection was favored by heparanase-1 (HPSE), and upregulated HPSE expression and secretion, which may have resulted in potentially pathogenic alterations of the ECM.
[Journal of Hepatology] |
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| Scientists investigated the cellular source for secreted anterior gradient-2 (AGR2) in the tumor microenvironment and underlying mechanisms mediating secreted AGR2’s effects.
[Gut] |
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| Researchers reported an electro-assembly pathway to create a dynamically adaptive intermediate molten fibril state for collagen.
[Science Advances] |
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| To endow hydrogel microspheres (HMs) with the ability to form self-renewable hydration layers and maintain cellular homeostasis, rapamycin-liposome–incorporating hyaluronic acid–based HMs were created using microfluidic technology and photopolymerization processes.
[Science Advances] |
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| Scientists showed, using a collagen-induced arthritis mouse model, that imidazole ketone erastin, a ferroptosis inducer, decreased fibroblast numbers in the synovium.
[Nature Communications] |
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| Investigators developed a multifunctional nanocomposite bioink based on amine-functionalized copper (Cu)-doped mesoporous bioactive glass nanoparticles and a hydrogel formulation that improved shape fidelity, and structural stability for extrusion-based bioprinting.
[Small] |
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| The authors found that pregnancies in mice with EZH2-deficient decidual stromal cells frequently failed by mid-gestation, with the decidua showing gene expression profiles associated with transforming growth factor β (TGF-β)-driven fibroblast activation and fibrogenic ECM remodeling.
[Cell Reports] |
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| Isolated matrix-bound nanovesicles (MBV) were delivered via intravenous or peri-articular injection to rats with pristane-induced arthritis. The results of MBV administration were compared to intraperitoneal administration of methotrexate, the clinical standard of care.
[NPJ Regenerative Medicine] |
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| Researchers analyzed the clinical impact of Sdc-1 expression by analysis of public gene expression datasets and studied the effect of overexpression of Sdc-1 and its membrane-bound and soluble forms on the malignant properties of the human cervical carcinoma cell line HeLa through functional analysis.
[Frontiers in Oncology] |
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| Investigators studied serum MMP3 and MMP9 as potential biomarkers of COVID-19 severity, in 108 hospitalized patients with different World Health Organization severity stage and in 48 controls.
[Scientific Reports] |
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| Scientists presented a computational framework for the characterization of invadopodia protrusions which allowed two way interactions between intracellular branched actin network and ECM fibers network.
[Scientific Reports] |
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| The authors present an overview of the complex biology of the kallikrein-related peptidase family and its context-dependent nature in cancer and discuss the different therapeutic strategies available to potentially target these proteases.
[Nature Reviews Cancer] |
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| Investigators studied the proteome profiled of canine native and decellularized placenta to characterize the proteome related to maintenance of a microenvironment and structure suitable for tissue engineering applications.
[Journal of Proteomics] |
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| Akeso, Inc. announced that Ligufalimab and Ivonescimab have obtained approval to initiate a Phase II clinical trial with chemotherapy as first-line therapy for unresectable locally advanced or metastatic triple-negative breast cancer.
[Akeso, Inc. (PR Newswire, Inc.)] |
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| 29 – 31 March, 2022
Boston, Massachusetts, United States |
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| | Severo Ochoa Centre for Molecular Biology – Madrid, Spain |
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| | Nanyang Technological University – Singapore, Singapore |
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| | Flanders Institute for Biotechnology – Leuven, Belgium |
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| | National University of Ireland Galway – Galway, Ireland |
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| | Mayo Clinic Florida Campus – Jacksonville, Florida, United States |
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Cancer Stem Cell News
Cell Therapy News
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