 | | Vol. 13.05 – 10 February, 2022 |
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| Researchers showed that late-stage Non-Hodgkin’s Lymphoma was resistant to therapy targeting phagocytosis checkpoint CD47, due to the compromised capacity of tumor-associated macrophages to phagocytose lymphoma cells.
[Blood] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors reported the engineering of a functional human neuronal network by mimicking the embryonic development of the spinal cord in a 3D dynamic biomaterial-based microenvironment.
[Advanced Science] |
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| Expression and lineage analysis showed selective expression of discoidin domain receptor 2 (Ddr2) at early stages of bone formation in the resting zone and proliferating chondrocytes and periosteum.
[Bone Research] |
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| Scientists developed a protocol to visualize and quantify the spatiotemporal evolution of newly synthesized and deposited matrix by cells that were either cultured atop or embedded within biomaterial systems.
[Nature Protocols] |
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| Digital image analysis of whole section slides was used to assess abundance and spatial distribution of T cells and tertiary lymphoid structures in the tumor immune microenvironment of 117 tumor samples.
[Clinical Cancer Research] |
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| Researchers used a recently developed composite hydrogel composed of a fibrin matrix and phase-shift emulsion, termed an acoustically-responsive scaffold, to investigate effects of local mechanical properties on breast cancer cell signaling.
[Advanced Healthcare Materials] |
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| Investigators examined the roles of surface topographies and cell-cell interactions in inducing cell alignment. They employed wavy surface topographies at the nanometer scale as a model extracellular environment for cell culture.
[Acta Biomaterialia] |
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| The authors investigated the impact of apoptotic colorectal cancer cells on neutrophils and its consequence on other immune cells of the tumor microenvironment.
[Cell Death & Disease] |
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| Androgens-androgen receptor (AR) signaling activated the AR/ARA55/FAK complex and induced the collagen-integrin α2β1 gene expression that was required for promoting the AR-mediated periosteum-derived progenitor cell migration.
[Cell Death & Disease] |
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| Scientists performed single-cell RNA sequencing of thoracic aortic cells from β-aminopropionitrile-induced thoracic aortic aneurysm and dissection mouse models at three time points that spanned from the early to the advanced stages of the disease.
[Cell Discovery] |
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| KDM6A promoted the transcription of SPARCL1 by demethylating histone H3 lysine trimethylation and consequently led to the inactivation of p65. SPARCL1 affected the metastasis of gastrointestinal stromal tumor cells in a mesenchymal-epithelial transition- and matrix-metalloproteinase-dependent manner.
[British Journal of Cancer] |
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| Investigators used engineered cartilage microtissues formed from bone marrow-derived stromal cells or expanded articular chondrocytes to study the impact of enzyme treatment on cartilage tissue integration and matrix remodeling.
[Journal of Tissue Engineering] |
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| Researchers used a library containing approved drugs to screen for drugs that preferentially reduce cell viability in lung fibroblasts from an idiopathic pulmonary fibrosis patient compared with a human alveolar epithelial cell line.
[Cell Death Discovery] |
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| Scientists introduce the classification, design, and assembly of DNA hydrogels, and then summarize the state-of-the-art achievements in cell encapsulation, cell culture, and tissue engineering with DNA hydrogels.
[Small] |
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| The authors explain the process of ECM stiffening and the ways it may affect biochemical pathways to induce chemoresistance in a clinic.
[British Journal of Cancer] |
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| MTF Biologics has awarded more than $1 million in funding to nine researchers across the nation through its 2021 Extramural Research Grants Program. This year’s recipients are leading research in diverse areas including bone regeneration, machine learning, women’s health, and orthopedic infection.
[MTF Biologics] |
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| February 24 – February 25, 2022
Virtual |
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| | Columbia University – New York, New York, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | University of Washington – Seattle, Washington, United States |
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| | Wayne State University School of Medicine – Detroit, Michigan, United States |
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| | Nanyang Technological University – Singapore, Singapore |
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