 | | Vol. 13.06 – 17 February, 2022 |
| |
|
|
| Volumetric bioprinting via optical tomography shaped organoid-laden gelatin hydrogels into complex centimeter-scale 3D structures in under 20 seconds.
[Advanced Materials] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| The authors found that a soft ECM empowered redox homeostasis. Cells cultured on a soft ECM displayed increased peri-mitochondrial F-actin, promoted by Spire1C and Arp2/3 nucleation factors, and increased DRP1- and MIEF1/2-dependent mitochondrial fission.
[Nature Cell Biology] |
|
|
|
| Scientists presented experiments and theory in support of a rigidity percolation framework that quantitatively described the structural origins of cartilage’s shear properties and how they arise from the mechanical interdependence of the collagen and aggrecan networks making up its ECM.
[Science Advances] |
|
|
|
| Researchers investigated how BRCA1/2 mutations shaped the cellular phenotypes and spatial interactions of the tumor microenvironment of high-grade serous ovarian cancers.
[Nature Communications] |
|
|
|
| Investigators used quantitative fluorescence and electron microscopy to reveal a mechanism where flat clathrin lattices partitioned and activated growth factor signals via a coordinated response that involved crosstalk between epidermal growth factor receptor and the adhesion receptor β5-integrin.
[Nature Communications] |
|
|
|
| Using metabolomics analysis and genetic in vivo models, the authors showed that maintaining intracellular serine homeostasis was essential for chondrocyte function.
[Bone Research] |
|
|
|
| Scientists reported that Mmp14-dependent ECM remodeling coordinated canonical Wnt signaling and guided stem cell fate by triggering an integrin-activated reorganization of the skeletal stem cell cytoskeleton that controlled nuclear lamin A/C levels via the linker of nucleoskeleton and cytoskeleton complexes.
[Developmental Cell] |
|
|
|
| Researchers found that inhibition of G protein-coupled receptor 4 (GPR4) with the antagonist NE52-QQ57 ameliorated osteoarthritis progression in mice, promoted ECM production, and protected cartilage from degradation in human articular cartilage explants.
[Cell Death & Disease] |
|
|
|
| Investigators showed that circ_0134111 level was overexpressed in intervertebral disc degeneration (IDD) tissue samples as compared to control tissues. The upregulation of circ_0134111 was more drastic in the moderate and severe IDD cases than in those with mild IDD.
[Cell Death Discovery] |
|
|
|
| Scientists developed a chemically synthetic culture substrate for human PSC attachment and maintenance. The substrate comprised a hydrophobic polyvinyl butyral-based polymer and a short peptide that enabled easy and uniform coating of various types of cell culture ware.
[Scientific Reports] |
|
|
|
| The authors reported that the deletion of dystroglycan (DG) in rat hippocampal cell cultures caused pronounced changes in the density and morphology of dendritic spines. They also noted a decrease in laminin, one of the major extracellular partners of DG.
[Scientific Reports] |
|
|
|
| Researchers developed a platform that utilized orthogonal photopatterning of stiffness and adhesivity gradients to fabricate individually accessible wells with discrete ECM conditions.
[Biophysical Journal] |
|
|
|
| Investigators found that in addition to increased cell motility, cancer cells exploited the elevated actomyosin force generation to remodel ECM and to deplete important co-stimulatory receptors on antigen-presenting cells, facilitating tumor progression.
[Biophysical Journal] |
|
|
|
|
| Scientists provide an overview of the composition and importance of the muscle stem cell microenvironment, and discuss relevant ECM proteins and how their mutations or dysregulation impact young and aged muscle tissue or contribute to diseases.
[NPJ Regenerative Medicine] |
|
|
|
| The authors provide an overview of the major mechanisms used by tumor cells to evade immune defenses and they critically expose the most optimistic engineering strategies to make CAR-T cell therapy a solid option for solid tumors.
[Frontiers in Immunology] |
|
|
|
|
| Paige and Flagship Biosciences announced a partnership to provide access to Flagship’s TissueInsight™, an AI-aided diagnostics software that quantifies PD-L1 expression in immunohistochemistry tissue samples, directly through the Paige Platform.
[Paige] |
|
|
|
|
| April 7 – April 9
Rome, Italy & Virtual |
|
|
|
|
|
| | Singapore-MIT Alliance for Research and Technology (SMART) Centre – Singapore, Singapore |
|
|
|
| | University of Washington – Seattle, Washington, United States |
|
|
|
| | Francis Crick Institute – London, England, United Kingdom |
|
|
|
| | Wayne State University School of Medicine – Detroit, Michigan, United States |
|
|
|
| | Nanyang Technological University – Singapore, Singapore |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
