Extracellular Matrix News Volume 13.08 | Mar 2 2022

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    2022-03-03 | ECM 13.08


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 13.08 – 3 March, 2022
    TOP STORY

    Pharmacological Perturbation of Mechanical Contractility Enables Robust Transdifferentiation of Human Fibroblasts into Neurons

    The authors reported a robust method to convert fibroblasts to neurons through targeting the cytoskeleton followed by exposure to lineage-specification surroundings.
    [Advanced Science]

    Full Article

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    Phase Separation on Cell Surface Facilitates bFGF Signal Transduction with Heparan Sulphate

    Investigators demonstrated that heparan sulfate could serve as a platform to induce the phase separation of basic fibroblast growth factor on cell surface.
    [Nature Communications]

    Full Article

    Extracellular Mechanical Forces Drive Endocardial Cell Volume Decrease during Zebrafish Cardiac Valve Morphogenesis

    Scientists studied the formation of the zebrafish atrioventricular canal where cardiac valves developed and identified how mechanical forces and ECM influenced tissue remodeling in developing organs.
    [Developmental Cell]

    Full ArticleGraphical Abstract

    Tumor Bud-Derived CCL5 Recruits Fibroblasts and Promotes Colorectal Cancer Progression via CCR5-SLC25A24 Signaling

    Researchers identified the fibroblast-mediated effect of tumor bud-derived C–C chemokine ligand 5 (CCL5) on the tumor microenvironment
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    An Organ-Derived Extracellular Matrix Triggers In Situ Kidney Regeneration in a Preclinical Model

    The authors presented that an organ-derived ECM in situ induced nephron regeneration in a preclinical model. The matrix provided structural and functional foundations for the development of cell-free scaffolds with a remarkably low risk of immune rejection and cancerization.
    [NPJ Regenerative Medicine]

    Full Article

    Tumor Microenvironment Remodeling Modulates Macrophage Phenotype in Breast Cancer Lymphangiogenesis

    Researchers studied the crosstalk between hyaluronan in the tumor microenvironment and macrophages dependent lymphangiogenesis, providing new insight into tumor microenvironment remodeling and macrophages in breast cancer lymphangiogenesis.
    [FASEB Journal]

    Abstract

    Development of Functional Hybrid Scaffolds for Wound Healing Applications

    Hybrid hydrogels composed of chitosan and hyaluronic acid and collagen were prepared by polyelectrolyte complex self-assembly.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    PD-L1 Mediates Lung Fibroblast to Myofibroblast Transition through Smad3 and β-Catenin Signaling Pathways

    Investigators demonstrated that fibroblast programmed death ligand-1 (PD-L1) may have promoted pulmonary fibrosis through both Smad3 and β-catenin signaling and may represent a novel interventional target for idiopathic pulmonary fibrosis.
    [Scientific Reports]

    Full Article

    Integrated Bioinformatics Analysis Identifies Established and Novel TGFβ1-Regulated Genes Modulated by Anti-Fibrotic Drugs

    To identify novel drug targets and uncover potential mechanisms by which these drugs attenuate fibrosis, scientists performed an integrative ‘omics analysis of transcriptomic and proteomic responses to TGFβ1-stimulated lung fibroblasts.
    [Scientific Reports]

    Full Article

    Laminin N-terminus α31 Is Upregulated in Invasive Ductal Breast Cancer and Changes the Mode of Tumor Invasion

    To study laminin N-terminus α31 (LaNt α31) function, an adenoviral system was used to induce expression in MCF-7 and MDA-MB-231 cells. 2D cell migration and invasion into collagen hydrogels were not significantly different between LaNt α31 overexpressing cells and control treated cells.
    [PLoS One]

    Full Article

    The Interaction of CD4+ Helper T Cells with Dendritic Cells Shapes the Tumor Microenvironment and Immune Checkpoint Blockade Response

    Researchers systematically characterized the interactions between T cells and antigen-presenting myeloid cells within the tumor microenvironment and found that CD4+PD-1+CXCL13+ T cells were a major interacting hub with antigen-presenting cells in the tumor microenvironment of human non-small cell lung carcinoma.
    [Nature Cancer]

    Abstract

    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    REVIEWS

    Recent Advances in Smart Stimuli-Responsive Biomaterials for Bone Therapeutics and Regeneration

    The authors summarize and discuss the rational construction of versatile biomaterials with bone therapeutic and regenerative functions.
    [Bone Research]

    Full Article

    Recent Trends in the Development of Hydrogel Therapeutics for the Treatment of Central Nervous System Disorders

    Scientists focus on the most recent advancements in hydrogel-based therapies for the treatment of central nervous system disorders, including brain injury, spinal cord injury, neurodegenerative diseases, and brain tumors.
    [NPG Asia Materials]

    Full Article

    INDUSTRY AND POLICY NEWS

    Biohaven Licenses Taldefgrobep Alfa, a Phase III-Ready Anti-Myostatin Adnectin for Spinal Muscular Atrophy (SMA), from Bristol Myers Squibb

    Biohaven Pharmaceutical Holding Company Ltd. announced that it entered into a license agreement with Bristol Myers Squibb for the development and commercialization rights to taldefgrobep alfa, a novel, Phase III-ready anti-myostatin adnectin.
    [Biohaven Pharmaceutical Holding Company Ltd.]

    Press Release

    CatalYm Commences Phase II Development of GDF-15-Targeting Antibody CTL-002 Following Successful Phase I Completion

    CatalYm announced treatment of the first patients in a series of Phase IIa cohorts targeting solid tumors, initiating Phase II development of CTL-002, a monoclonal antibody against the novel cancer target growth and differentiation factor 15 (GDF-15).
    [CatalYm]

    Press Release

    FEATURED EVENT

    AACR Annual Meeting 2022

    2022-04-08-2022-04-13 |
    New Orleans, Louisiana, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Morphogenesis and Differentiation

    University of Edinburgh – Edinburgh, Scotland, United Kingdom

    Senior Research Investigator – Biomedical Sciences

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    Research Technician – Placental Development

    Friedrich Miescher Institute for Biomedical Research – Basel, Switzerland

    PhD Position – Tumor Tissue Engineering

    University of Lausanne – Lausanne, Switzerland

    Research Fellow – Biomaterials Engineering

    National University of Singapore – Queenstown, Singapore

    > See All Jobs

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