 | | Vol. 13.09 – 10 March, 2022 |
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| Vibrio cholerae was used as a model organism to investigate biofilm mechanics in the nonlinear rheological regime by systematically examining the role of each constituent matrix component.
[Advanced Functional Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported that the targeting of HIF-1α suppressed PD-L1 expression on tumor cells and tumor-infiltrated myeloid cells, but unexpectedly induced PD-L1 in normal tissues by an IFNγ–dependent mechanism.
[Journal of Clinical Investigation] |
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| A 3D in vitro tumor model using micro-molded hydrogels, the Gels for Live Analysis of Compartmentalized Environments platform, was adapted into a 96-well plate format that integrated patient-derived organoids and was combined with longitudinal automated imaging.
[Biomaterials] |
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| The authors extracted and identified primary MSCs and verified the promoting effects of tumor-associated MSCs on colorectal cancer proliferation and metastasis in vivo and in vitro.
[Molecular Therapy] |
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| Researchers developed gethacrylate gelatin (GelMA)/ECM hydrogel fibrous scaffolds that could recruit and enhance the differentiation of neural stem cells by electrospinning and decellularization techniques.
[NPG Asia Materials] |
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| Scientists developed a transgenic mouse line overexpressing the circular RNA circNlgn and showed that circNlgn was a mediator of Doxorubicin-induced cardio-fibrosis.
[Molecular Therapy-Nucleic Acids] |
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| The authors found that the expression of EP4 was largely increased in the injured articular cartilage in both humans and mice. Knocking out EP4 in cartilage enhanced stable mature articular cartilage formation instead of fibrocartilage, and reduced joint pain.
[Cell Discovery] |
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| Using biomimetic ECM hydrogels with tunable stiffness, investigators showed that increased ECM stiffness elevated Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) nuclear localization potentially through modulating focal adhesions and cytoskeletal rearrangement.
[Frontiers in Cell and Developmental Biology] |
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| Human intestinal organoids expressed core mitochondrial and ECM genes and enriched biologic functions implicated in Crohn’s disease ileal strictures; ECM gene expression was suppressed by both butyrate and eicosatetraynoic acid, with butyrate also suppressing genes regulating epithelial proliferation.
[Inflammatory Bowel Diseases] |
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| Urethral stricture rats showed increased gene and protein expression of collagen I, collagen III, and TGFβ1R, while stromal vascular fraction cells administration contributed to decreased gene and protein expression of collagen I, collagen III, and TGFβ1R.
[Scientific Reports] |
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| The influence of two different genipin crosslinking routes on collagen-based scaffolds in terms of human mesenchymal stem cells chondrogenic differentiation and biomechanical performances was investigated.
[Journal of Biomedical Materials Research Part A] |
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| Researchers developed a TGF-β1-silk fibroin blended with polylysine modified chitosan polymer injectable hydrogel that demonstrated enhanced in vitro and in vivo tissue regeneration properties, which led to efficacious therapeutic potential in cartilage regeneration.
[International Wound Journal] |
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| Investigators highlight areas of consensus as well as contentious issues in our understanding of the intracellular and intercellular journey of extracellular vesicles: from biogenesis, release and dynamics in the extracellular space, to interaction with and uptake by recipient cells.
[Nature Reviews Molecular Cell Biology] |
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| Scientists describe mechanisms by which tumor ecosystems, including cancer cells, immune cells and stroma, adapt to therapeutic stresses and describe three different approaches to exploit stress mitigation processes.
[Nature Reviews Cancer] |
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| The authors discuss the interactions between hydrogel matrices and engineered living cells, focusing on how hydrogels influence cell behaviors and how cells affect hydrogel properties.
[Advanced Materials] |
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| Pliant Therapeutics, Inc. announced positive data from its expanded PLN-74809 Phase Ib proof-of-mechanism trial. Results showed that PLN-74809 inhibited TGF-β activation on day seven by up to 92% and 76% at six and twenty-four hours, respectively, following dosing.
[Pliant Therapeutics, Inc.] |
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| May 25-29, 2022
Lyon, France |
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| | Aspect Biosystems – Vancouver, British Columbia, Canada |
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| | University of Michigan School of Dentistry – Ann Arbor, Michigan, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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| | Friedrich Miescher Institute for Biomedical Research – Basel, Switzerland |
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