 | | Vol. 13.13 – 7 April, 2022 |
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| Scientists profiled 54,103 cells from tumor and adjacent tissues to characterize cellular composition and elucidated the potential origin and regulation of tumor-enriched cell types in colorectal cancer.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors reported an open microfluidic system for culturing adherent single cells, implemented by a micrometer-scale droplet matrix on an inkjet-printed polylysine template.
[Small] |
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| Researchers developed an in situ sustained-release hydrogel delivery system for combined chemo-immunotherapy of glioma by combined chemotherapy drug and immunoadjuvant through the resection cavity local delivery.
[Journal of Controlled Release] |
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| Investigators showed that RNA contributed to the structural integrity of biofilms formed by the human pathogen Staphylococcus aureus.
[NPJ Biofilms and Microbiomes] |
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| The authors used a monoclonal antibody targeting the C-telopeptide of type III collagen following C-proteinase cleavage to develop and validate a neo-epitope-specific enzyme-linked immunosorbent assay.
[Liver International] |
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| Researchers observed that cell migration-inducing protein (CEMIP) upregulation facilitated ferroptosis resistance during ECM detachment by promoting cystine uptake in prostate cancer cells.
[Cancer Science] |
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| Researchers investigated the potential of using a selective histone deacetylase 2 and 3 inhibitor, MI192, to promote human dental pulp stromal cells bone-like tissue formation in vitro and in vivo within porous Bombyx Mori silk scaffolds.
[Cell and Tissue Research] |
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| The authors created tissue-engineered human fibrous cap models with a variable but controllable collagen composition, suitable for mechanical testing, to scrutinize the reciprocal relationships between composition and mechanical properties of cap rupture.
[Scientific Reports] |
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| Researchers demonstrated that the use of accutase for cellular detachment may have compromised some surface proteins. Compared with ethylenediaminetetraacetic acid-based nonenzymatic cell dissociation buffers, accutase was associated with significant decreases in the surface Fas ligands and Fas receptors.
[Scientific Reports] |
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| Investigators successfully established an animal model of ear molding and demonstrated that immature cartilage was associated with better plasticity. They also found that the cartilage’s biomechanical property increased with the accumulation of ECM.
[Laryngoscope] |
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| The embryonic development process and the pro-myogenic role of the muscle-resident cell populations in co-cultures are described, highlighting the possible clinical applications of induced pluripotent stem cells (iPSCs) in the skeletal muscle tissue engineering field.
[NPJ Regenerative Medicine] |
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| Scientists discuss the communication between peripheral nerves and tumor cells in the tumor microenvironment, and reveal the nerve-tumor regulation mechanisms on oncogenic process, angiogenesis, lymphangiogenesis, and immunity.
[Cell Death Discovery] |
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| The authors introduce the anatomy and function of the skin and the process of wound healing and conventional wound dressings, then discuss the composition and construction methods of hydrogels.
[Macromolecular Bioscience] |
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| NGM Biopharmaceuticals, Inc. announced it has dosed the first patient in a Phase I/Ib clinical trial of NGM831, an antagonist antibody product candidate designed to block the interaction of ILT3 with fibronectin, a key component of the tumor stroma, for the treatment of patients with advanced solid tumors.
[NGM Biopharmaceuticals, Inc.] |
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| June 20 – 23, 2022
Sevilla, Spain |
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| | Luxembourg Institute of Health – Luxembourg, Luxembourg |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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| | University of California, San Diego – La Jolla, California, United States |
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| | Mayo Clinic – Jacksonville, Florida, United States |
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| | The Wellcome Trust – London, England, United Kingdom |
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